Abstract: A device that is implantable in body tissue of a human or animal. The device is comprised of a header comprising at least one terminal adapted for removable connection to a lead and an open ended case closed by a plate to form a housing. The housing is comprised of a surrounding edge wall joined to a first side wall and a second side wall opposed to the first side wall. At least a first suture port extends through the edge wall and the second side wall but not the first side wall at an upper edge region of the housing. A second suture port may extend through the surrounding edge wall and the second side wall but not the first side wall in a similar manner. A third suture port may extend through the header. The three suture ports may define a triangular attachment configuration.

Abstract: A device that is implantable in body tissue of a human or animal. The device is comprised of a header comprising at least one terminal adapted for removable connection to a lead and an open ended case closed by a plate to form a housing. The housing is comprised of a surrounding edge wall joined to a first side wall and a second side wall opposed to the first side wall. At least a first suture port extends through the edge wall and the second side wall but not the first side wall at an upper edge region of the housing. A second suture port may extend through the surrounding edge wall and the second side wall but not the first side wall in a similar manner. A third suture port may extend through the header. The three suture ports may define a triangular attachment configuration.

Abstract: A system for stimulation of a nerve and measuring impedance. The system includes a neural interface device including a plurality of electrodes; a voltage or current source operatively connected to at least a subset of the electrodes, wherein the voltage or current source is configured to generate an electrical signal to be applied to the electrodes; an impedance measuring module operatively connected to at least a subset of the electrodes, wherein the impedance measurement module is configured to measure the impedance between the electrodes; and a controller arranged to determine an amplitude of an action potential induced in the nerve, via the electrical signal, based on the measured impedance and to adjust the electrical signal in order to induce an action potential having a target amplitude.

Abstract: Devices and systems described herein relate to a sensing device that includes an output area and an electrode area. The output area includes an output circuit comprising an integrator adapted to integrate a received current so as to generate an output voltage corresponding to the received current. The electrode area includes an electrode comprising an exposed, electrically conductive, surface area and electrode circuitry connected to the exposed surface area. The electrode circuitry comprises a voltage-to-current transducer adapted to produce a wire current corresponding to a voltage present at the exposed surface area. The sensing device also includes a connecting wire electrically connecting the electrode circuitry to the output circuit, wherein the current received by the output circuit is the wire current.

Abstract: A device that is implantable in body tissue of a human or animal. The device is comprised of a header comprising at least one terminal adapted for removable connection to a lead and an open ended case closed by a plate to form a housing. The housing is comprised of a surrounding edge wall joined to a first side wall and a second side wall opposed to the first side wall. At least a first suture port extends through the edge wall and the second side wall but not the first side wall at an upper edge region of the housing. A second suture port may extend through the surrounding edge wall and the second side wall but not the first side wall in a similar manner. A third suture port may extend through the header. The three suture ports may define a triangular attachment configuration.

Abstract: A biopotential signal acquisition system, comprising: a first active electrode including an integrated pre-amplifier and an analogue to digital converter; a second active electrode including an integrated pre-amplifier and an analogue to digital converter, wherein the second active electrode has variable gain; a test signal generator for generating a test signal at a test frequency and coupling the test signal to the first and/or second active electrodes; and a digital signal processor configured to: process the digital outputs of the first and second active electrodes to derive a gain control signal based on a difference between the first and second active electrode outputs at the test frequency, and apply the gain control signal to the second active electrode. The disclosure also relates to an electronic circuit or device and a biopotential signal acquisition method.

Abstract: Devices and systems described herein relate to a sensing device that includes an output area and an electrode area. The output area includes an output circuit comprising an integrator adapted to integrate a received current so as to generate an output voltage corresponding to the received current. The electrode area includes an electrode comprising an exposed, electrically conductive, surface area and electrode circuitry connected to the exposed surface area. The electrode circuitry comprises a voltage-to-current transducer adapted to produce a wire current corresponding to a voltage present at the exposed surface area. The sensing device also includes a connecting wire electrically connecting the electrode circuitry to the output circuit, wherein the current received by the output circuit is the wire current.

Abstract: A current generator is disclosed. An example current generator includes a plurality of current cells connected in parallel, each current cell being connected to a switch. The current generator further includes a first summer configured to sum the output of each current cell of a first subset of the plurality of current cells and a second summer configured to sum the output of each current cell of a second subset of the plurality of current cells. The current generator also includes a combiner configured to combine the outputs of the first and second summers. Further, each switch is switchable according to a sequence to generate a summed output of the current cells at a plurality of quantization levels to generate positive and/or negative alternations of a pseudo-sinusoidal, alternating current.

Abstract: A biopotential signal acquisition system including an analog readout unit configured to receive an analog biopotential signal, which may be acquired from at least one electrode attached to a body; and to extract an analog measured biopotential signal and an analog reference signal. The system also includes an ADC unit configured to provide a digital version of the analog measured biopotential signal and the analog reference signal, a digital filter unit configured to calculate a digital motion artifact estimate based on the digital version of the measured biopotential signal and the reference signal. The system further comprises a reference signal processing unit configured to convert the reference signal into a new reference signal being provided to the digital filter unit based on the correlation between the measured biopotential signal and the reference signal.

Abstract: A biopotential signal acquisition system comprising an analog readout unit configured to receive an analog biopotential signal and to extract an analog measured biopotential signal and an analog reference signal, and an ADC unit configured to provide a digital version of the analog measured biopotential signal and the analog reference signal. The system also includes a first digital filter unit comprising a cascaded integrator-comb filter configured to provide a first digital filtered version of the digital measured biopotential signal and the reference signal, and a second digital filter unit configured to calculate a digital motion artifact estimate based on the first digital filtered version signals.

Abstract: An instrumentation amplifier includes a first amplifier having one input connected to a first input of the instrumentation amplifier, a second amplifier having one input connected to a second input of the instrumentation amplifier, and a feedback network. The feedback network including an active filter having a first low pass filter characteristic with a first cut-off frequency in respect of differential mode signals at the first and second inputs of the instrumentation amplifier, and a second low pass filter characteristic with a second cut-off frequency in respect of common mode signals at the first and second inputs of the instrumentation amplifier. The disclosure also relates to a device for acquiring biopotential signals and a signal amplification method.

Abstract: A biological signal detecting apparatus includes a BPF to which a biological signal is input via a lead directly connected to a subcutaneous tissue that emits the biological signal including a predetermined signal of a first frequency and which outputs a filtered biological signal by filtering a biological event signal of a predetermined frequency including the first frequency; and a peak detecting means to which at least the filtered biological signal is input and which detects a peak location of the biological event signal. The BPF includes a first order HPF which filters a frequency higher than a second frequency and a first order LPF which filters a frequency lower than a third frequency. The HPF and the LPF are connected in series between the lead and the peak detecting means. A difference between the second frequency and the third frequency is less than or equal to 10 Hz.

Abstract: A biopotential signal acquisition system comprising an analogue readout unit configured to receive an analogue biopotential signal and to extract an analogue measured biopotential signal and an analogue reference signal, and an ADC unit configured to provide a digital version of the analogue measured biopotential signal and the analogue reference signal. The system also includes a first digital filter unit comprising a cascaded integrator-comb filter configured to provide a first digital filtered version of the digital measured biopotential signal and the reference signal, and a second digital filter unit configured to calculate a digital motion artifact estimate based on the first digital filtered version signals.

Abstract: A biopotential signal acquisition system including an analogue readout unit configured to receive an analogue biopotential signal, which may be acquired from at least one electrode attached to a body; and to extract an analogue measured biopotential signal and an analogue reference signal. The system also includes an ADC unit configured to provide a digital version of the analogue measured biopotential signal and the analogue reference signal, a digital filter unit configured to calculate a digital motion artifact estimate based on the digital version of the measured biopotential signal and the reference signal. The system further comprises a reference signal processing unit configured to convert the reference signal into a new reference signal being provided to the digital filter unit based on the correlation between the measured biopotential signal and the reference signal.

Abstract: A system for the acquisition of biopotential signals, comprising at least a first electrode configured for detecting a biopotential signal within a signal bandwidth of interest and being connected to an impedance detection module that provides a first electrode voltage. The impedance detection module comprises a current generation circuit connected in parallel to an amplifier. The current generation circuit comprises an AC current generator configured to generate a first current signal through the first electrode. The first current signal has a frequency outside of the signal bandwidth of interest. The current generation circuit also comprising a capacitor connected between the input of the amplifier and the AC current generator so as to isolate the AC current generator from the amplifier input at the signal bandwidth of interest.

Abstract: A multi-channel biopotential signal acquisition system is disclosed. In the system, a plurality of biopotential channels is corrected for common-mode interference. In one aspect, each biopotential channel includes an electrode for providing a biopotential input signal and an associated amplifier for amplifying the biopotential input signal and providing a biopotential output signal. The output signal is processed in a processor. Each biopotential output signal is passed to a common-mode feedback system, which determines an average common-mode signal and feeds that signal back to each of the amplifiers in each of the biopotential channels to enhance common-mode rejection ratio of the system.

Abstract: An instrumentation amplifier includes a first amplifier having one input connected to a first input of the instrumentation amplifier, a second amplifier having one input connected to a second input of the instrumentation amplifier, and a feedback network. The feedback network including an active filter having a first low pass filter characteristic with a first cut-off frequency in respect of differential mode signals at the first and second inputs of the instrumentation amplifier, and a second low pass filter characteristic with a second cut-off frequency in respect of common mode signals at the first and second inputs of the instrumentation amplifier. The disclosure also relates to a device for acquiring biopotential signals and a signal amplification method.

Abstract: A biopotential signal acquisition system, comprising: a first active electrode including an integrated pre-amplifier and an analogue to digital converter; a second active electrode including an integrated pre-amplifier and an analogue to digital converter, wherein the second active electrode has variable gain; a test signal generator for generating a test signal at a test frequency and coupling the test signal to the first and/or second active electrodes; and a digital signal processor configured to: process the digital outputs of the first and second active electrodes to derive a gain control signal based on a difference between the first and second active electrode outputs at the test frequency, and apply the gain control signal to the second active electrode. The disclosure also relates to an electronic circuit or device and a biopotential signal acquisition method.

Abstract: A system for the analysis of ECG signals is disclosed. The system may comprise (i) at least one readout channel, configured to receive an analog ECG signal acquired from at least one electrode attached to a body, and to extract an analog measured ECG signal and analog electrode-skin impedance signals; (ii) at least one ADC, configured to convert those extracted analog signals at the readout channel into digital signals; (iii) a digital adaptive filter unit, configured to calculate a digital motion artifact estimate based on said digital versions of the measured ECG signal and the electrode-skin impedance signals; (iv) at least one DAC, configured to convert said digital motion artifact estimate into an analog signal; and (v) a feedback loop for sending said analog motion artifact estimate signal back to the readout channel configured to deduct said analog motion artifact estimate signal from said analog measured ECG signal.

Abstract: A microprocessor configured to receive and process digitized signals derived from an analogue ECG signal is provided. An example microprocessor comprises a beat detection unit configured to receive the in-phase and quadrature phase band power signals, calculate a band power value and an adaptive threshold value, and compare said band power value with said adaptive threshold value to detect a QRS complex of the ECG signal indicative of a detected valid beat; and an R peak detection unit configured to receive the digital ECG signal and information about the detected valid beat, select a portion of the received ECG signal as a first time window around the detected valid beat; determine the location of a first R peak position; and perform a time domain search in a second time window around said first R peak position in order to refine the location of an R peak position.