Abstract: A system and method for automated medication refill are provided, wherein the system and method reduce the time spent on, and potential for error in, accommodating medication refill requests. In one embodiment, the system includes a computer device for executing a medication information input function, a patient information input function, a refill protocol determination function, a refill analysis function, and an automated refill advisory output function. In a preferred embodiment, the system also executes an automatic pharmacy refill authorization function. The system includes a database incorporated therein or in electronic communication therewith. The system and method of the present invention provide a mechanism for medication refill protocols that provides specific patient care guidance for prescribed medications.