Patents by Inventor Reggie Y. C. Lo

Reggie Y. C. Lo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified leukotoxin gene and protein
    Patent number: 7932085
    Abstract: The present invention provides nucleic acid sequences encoding a modified leukotoxin protein, wherein the modification comprises the removal of nucleic acid sequences encoding amino acids within hydrophobic transmembrane domains of full length leukotoxin protein, preferably from Mannheimia haemolytica. The modified leukotoxin proteins are useful in vaccine compositions effective against Mannheimia haemolytica in animals.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: April 26, 2011
    Assignee: University of Guelph
    Inventors: Reggie Y. C. Lo, Patricia E. Shewen, Raymond W. H. Lee, Doug Hodgins, Judith N. Strommer
  • Modified leukotoxin protein
    Patent number: 7790170
    Abstract: The present invention provides nucleic acid sequences encoding a modified leukotoxin protein, wherein the modification comprises the removal of nucleic acid sequences encoding amino acids within hydrophobic transmembrane domains of full length leukotoxin protein, preferably from Mannheimia haemolytica. The modified leukotoxin proteins are useful in vaccine compositions effective against Mannheimia haemolytica in animals.
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: September 7, 2010
    Assignee: University of Guelph
    Inventors: Reggie Y. C. Lo, Patricia E. Shewen, Raymond W. H. Lee, Doug Hodgins, Judith N. Strommer
  • Transferrin binding proteins of Pasteurella haemolytica and vaccines containing same
    Patent number: 6610506
    Abstract: Novel transferrin binding proteins from Pasteurella haemolytica, and nucleic acid molecules encoding the novel proteins are disclosed. Antibodies against the novel proteins are disclosed. The invention also relates to vaccines containing the novel proteins of the invention. The invention also provides methods for identifying substances which affect the binding of transferrin to the proteins and methods for screening for agonists or antagonists of the binding of the proteins and transferrin.
    Type: Grant
    Filed: November 29, 1996
    Date of Patent: August 26, 2003
    Assignees: University Technologies International, Inc., University of Guelph, University of Saskatchewan
    Inventors: Reggie Y. C. Lo, Anthony Bernard Schryvers, Andrew Allan Potter
  • Pastuerella haemolytica glycoprotease gene and the purified enzyme
    Patent number: 5543312
    Abstract: A purified DNA molecule encoding a glycoprotease from Pasteurella haemolytica is disclosed. The DNA comprises a sequence of approximately 975 base pairs coding for a glycoprotease having a molecular weight of approximately 35.2 kD. The glycoprotease is specific for cleaving O-glycosylated carbohydrate portions from O-glycoproteins. The glycoprotease has a major cleavage site in glycophorin A between Arg31 and Asp32.
    Type: Grant
    Filed: August 12, 1993
    Date of Patent: August 6, 1996
    Assignee: University of Guelph
    Inventors: Alan Mellors, Reggie Y. C. Lo, Khalid M. Abdullah
  • Leukotoxin gene of pasteurella haemolytica
    Patent number: 5055400
    Abstract: The gene coding for Pasteurella haemolytica leukotoxin can be cloned in a plasmic expressed in Escherichia coli. The leukotoxin gene can be isolated from a clone bank of P. haemolytica. The clone bank is constructed by partial digestion of genomic DNA. The resultant 5 to 10 kilobase-pair fragments are ligated into plasmid vector pBR322. The resultant clones are screened for the production of P. haemolytica soluble antigens by a colony enzyme-linked immunosorbent assay blot method with a rabbit antiserum raised against the soluble antigens. The clones producing P. haemolytica soluble antigens are then analyzed for the production of the leukotoxin by a cytotoxicity assay with cells from a bovine leukemia-derived B-lymphocyte cell line as the target cells. Positive clones are identified, and subsequent restriction analysis of the recombinant plasmids shows the same insert DNA is cloned in the plasmid vector. The DNA sequence analysis of the insert DNA reveals regions coding for the leukotoxin.
    Type: Grant
    Filed: November 26, 1986
    Date of Patent: October 8, 1991
    Assignee: University of Guelph
    Inventors: Reggie Y. C. Lo, Patricia E. Shewen, Craig A. Strathdee