Abstract: A system and method for personalized calibration for glucose sensing. In some embodiments, the method includes obtaining a plurality of first glucose measurements from a subject, at a plurality of first sampling times during a time interval, using a first glucose sensor; obtaining a plurality of second glucose measurements from the subject, at a plurality of second sampling times during the time interval, using a second glucose sensor; and estimating a first in-vivo calibration parameter for the first glucose sensor and the second glucose sensor, based on the first glucose measurements and the second glucose measurements, wherein a first in-vivo time-constant, relating blood glucose to an output of the first glucose sensor, is different from a second in-vivo time-constant, relating blood glucose to an output of the second glucose sensor.

Abstract: A signal acquisition circuit detects a wanted signal in a composite signal containing the wanted signal and an unwanted signal, where the highest frequency in the unwanted signal is higher than the highest frequency in the wanted signal. A sensor captures the composite signal and an analog-to-digital converter samples and converts the composite signal to digital format, and a filter subtracts the unwanted signal from the composite signal. The sampled signal contains a first component containing the sum of the wanted signal and the unwanted signal sampled at a first rate at least equal to the Nyquist rate for the wanted signal but less than a second rate that is at least equal to the Nyquist rate for the unwanted signal, and a second component containing the unwanted signal sampled at the second rate.

Abstract: A signal acquisition circuit detects a wanted signal in a composite signal containing the wanted signal and an unwanted signal, where the highest frequency in the unwanted signal is higher than the highest frequency in the wanted signal. A sensor captures the composite signal and an analog-to-digital converter samples and converts the composite signal to digital format, and a filter subtracts the unwanted signal from the composite signal. The sampled signal contains a first component containing the sum of the wanted signal and the unwanted signal sampled at a first rate at least equal to the Nyquist rate for the wanted signal but less than a second rate that is at least equal to the Nyquist rate for the unwanted signal, and a second component containing the unwanted signal sampled at the second rate.