Patents by Inventor Regina Heinzel

Regina Heinzel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimeric proteins having fibrinolytic and thrombin-inhibiting properties
    Patent number: 6133011
    Abstract: Chimeric proteins with fibrinolytic and thrombin-inhibiting properties having a plasminogen-activating amino acid sequence which is linked at its C-terminal end to a thrombin-inhibiting amino acid sequence.
    Type: Grant
    Filed: November 10, 1997
    Date of Patent: October 17, 2000
    Assignee: Gruenenthal GmbH
    Inventors: Stephan Wnendt, Gerd Josef Steffens, Elke Janocha, Regina Heinzel-Wieland
  • Proteins having fibrinolytic and coagulation--inhibiting properties
    Patent number: 5976841
    Abstract: Proteins having fibrinolytic and coagulation-inhibiting properties which are linked at the N- and/or C-terminal end of the plasminogen-activating amino acid sequence to a thrombin- or factor Xa-inhibiting amino acid sequence. The proteins, which are produced by genetic engineering, are useful as thrombolytic agents.
    Type: Grant
    Filed: November 17, 1995
    Date of Patent: November 2, 1999
    Assignee: Gruenenthal GmbH
    Inventors: Stephan Wnendt, Regina Heinzel-Wieland, Gerd Josef Steffens
  • Bifunctional urokinase variants with improved fibrinolytic characteristics and thrombin inhibiting effect
    Patent number: 5747291
    Abstract: Bifunctional urokinase variants possessing improved fibrinolytic properties and thrombin inhibitory activities, plasmids used in the production of these polypeptides, as well as thrombolytic agents containing one of the bifunctional urokinase variants as active ingredient are described.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: May 5, 1998
    Assignee: Gruenenthal GmbH
    Inventors: Gerd J. Steffens, Stephan Wnendt, Johannes Schneider, Regina Heinzel-Wieland, Derek John Saunders
  • Bifunctional urokinase variants with improved fibrinolytic characteristics and thrombin inhibiting effect
    Patent number: 5681721
    Abstract: Bifunctional urokinase variants possessing improved fibrinolytic properties and thrombin inhibitory activities, plasmids used in the production of these polypeptides, as well as thrombolytic agents containing one of the bifunctional urokinase variants as active ingredient are described.
    Type: Grant
    Filed: July 20, 1993
    Date of Patent: October 28, 1997
    Assignee: Gruenenthal GmbH
    Inventors: Gerd J. Steffens, Stephan Wnendt, Johannes Schneider, Regina Heinzel-Wieland, Derek John Saunders
  • DNA sequences coding for proteins having the biological activity of HUSI-type I inhibitors, biotechnological methods for the preparation of said proteins and pharmaceutical compositions containing said proteins
    Patent number: 4845076
    Abstract: There are described DNA sequences from the genome of mammals, in particular from the human genome, coding for proteins having the biological activity of HUSI-type I inhibitors. There are further described biotechnological methods of the preparation of proteins having the biological activity of HUSI-type I inhibitors as well as pharmaceutical compositions containing said proteins.
    Type: Grant
    Filed: January 9, 1987
    Date of Patent: July 4, 1989
    Assignee: Grunenthal GmbH
    Inventors: Regina Heinzel, Heribert Appelhans, Hans G. Gassen, Werner Machleidt, Ursula Seemuller