Patents by Inventor Regina Reszka
Regina Reszka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10436798Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject and a method for monitoring progression or regression of heart failure in a subject. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: GrantFiled: July 27, 2012Date of Patent: October 8, 2019Assignees: Metanomics GmbH, Ruprecht-Karls-Universität HeidelbergInventors: Regina Reszka, Jens Fuhrmann, Jürgen Kastler, Bianca Bethan, Martin Kluttig, Hugo A. Katus, Norbert Frey, Johanna Wolf, Tanja Weis
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Patent number: 10393762Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject, a method for identifying whether a subject is in need for a therapy of heart failure or a method for determining whether a heart failure therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: GrantFiled: February 1, 2016Date of Patent: August 27, 2019Assignees: METANOMICS GMBH, Ruprecht-Karls-Universitaet HeidelbergInventors: Jens Fuhrmann, Regina Reszka, Juergen Kastler, Kristina Busch, Edgar Leibold, Hugo Katus, Norbert Frey, Johanna Sigl, Tanja Weis
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Patent number: 10168333Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing pancreas cancer in a subject and, preferably for differentiating between pancreatic cancer and pancreatitis and a method for identifying whether a subject is in need for a therapy of pancreatic cancer. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: GrantFiled: December 19, 2014Date of Patent: January 1, 2019Assignee: METANOMICS HEALTH GMBHInventors: Beate Kamlage, Regina Reszka, Erik Peter, Jürgen Kastler, Philipp Schatz, Holger Kalthoff, Bodo Schniewind, Julia Mayerle, Markus Lerch, Christian Pilarsky, Robert Grützmann
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Patent number: 10139413Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing pancreas cancer in a subject and, preferably for differentiating between pancreatic cancer and pancreatitis and a method for identifying whether a subject is in need for a therapy of pancreatic cancer. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: GrantFiled: December 19, 2014Date of Patent: November 27, 2018Assignee: METANOMICS HEALTH GMBHInventors: Beate Kamlage, Regina Reszka, Erik Peter, Jürgen Kastler, Philipp Schatz, Holger Kalthoff, Bodo Schniewind, Julia Mayerle, Markus Lerch, Christian Pilarsky, Robert Grützmann
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Publication number: 20180180619Abstract: The present invention relates to a method for diagnosing pancreatic cancer in a subject comprising the steps of: (a) determining in at least one sample of said subject the amounts of a group of diagnostic biomarkers comprising (i) at least one diagnostic amino acid, said diagnostic amino acid being proline, histidine or tryptophan, preferably, being proline; (ii) at least one diagnostic ceramide, said diagnostic ceramide being ceramide (d18:1,C24:0) or ceramide (d18:2,C24:0), preferably being ceramide (d18:1,C24:0); (iii) at least one diagnostic sphingomyelin, said diagnostic sphingomyelin being sphingomyelin (35:1), sphingomyelin (d17:1,C16:0), sphingomyelin (41:2) or sphingomyelin (d18:2,C17:0), preferably being sphingomyelin (35:1); and (iv) CA19-9; and (b) comparing said amounts of the diagnostic biomarkers with a reference, whereby pancreatic cancer is diagnosed.Type: ApplicationFiled: June 24, 2016Publication date: June 28, 2018Applicant: METANOMICS HEALTH GMBHInventors: Beate Kamlage, Regina Reszka, Philip Schatz, Martin Dostler, Susan Carvalho, Erik Peter, Philipp Mappes, Holger Kalthoff, Bodo Schniewind, Julia Mayerle, Marcus Lerch, Robert Gruetzmann, Christian Pilarsky
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Publication number: 20160313338Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing pancreas cancer in a subject and, preferably for differentiating between pancreatic cancer and pancreatitis and a method for identifying whether a subject is in need for a therapy of pancreatic cancer. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: ApplicationFiled: December 19, 2014Publication date: October 27, 2016Inventors: Beate Kamlage, Regina Reszka, Erik Peter, Jürgen Kastler, Philipp Schatz, Holger Kalthoff, Bodo Schniewind, Julia Mayerle, Markus Lerch, Christian Pilarsky, Robert Grützmann
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Publication number: 20160154012Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject, a method for identifying whether a subject is in need for a therapy of heart failure or a method for determining whether a heart failure therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: ApplicationFiled: February 1, 2016Publication date: June 2, 2016Applicants: Metanomics GmbH, Rupreht-Karls-Universität HeidelbergInventors: Jens Fuhrmann, Regina Reszka, Jürgen Kastler, Kristina Busch, Edgar Leibold, Hugo A. Katus, Norbert Frey, Johanna Wolf, Tanja Weis
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Patent number: 9285378Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject, a method for identifying whether a subject is in need for a therapy of heart failure or a method for determining whether a heart failure therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: GrantFiled: January 28, 2011Date of Patent: March 15, 2016Assignees: Metanomics GmbH, Rupreht-Karls-Universität HeidelbergInventors: Jens Fuhrmann, Regina Reszka, Jürgen Kastler, Kristina Busch, Edgar Leibold, Hugo Katus, Norbert Frey, Johanna Wolf, Tanja Weis
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Publication number: 20160047829Abstract: The present invention relates to a method for determining a clearance normalized amount of a metabolite disease biomarker in a sample including the steps of (a) determining the amount of the disease biomarker in at least a first type of sample of a subject suspected to suffer from the disease, (b) determining the amount of a kidney function biomarker which correlates with the glomerular filtration rate (GFR) in the said at least first type of sample, and (c) determining a clearance normalized amount for the metabolite disease biomarker by normalizing the amount determined for the metabolite disease biomarker in step (a) to the amount of the kidney function biomarker determined in step (b). Moreover, the invention also relates to a method for diagnosing a disease in a subject suspected to suffer therefrom and to a device for determining a clearance normalized amount of a metabolite disease biomarker in a sample.Type: ApplicationFiled: October 16, 2013Publication date: February 18, 2016Applicants: Ruprecht-Karls-Universität Heidelberg, Metanomics GmbHInventors: Jens Fuhrmann, Jenny Fischer, Regina Reszka, Hugo A Katus, Nobert Frey, Johanna Sigl, Tanja Weis
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Publication number: 20150241406Abstract: The present invention concerns means and methods for cancer diagnosis and, in particular, diagnosis of prostate cancer. Specifically, it relates to a method for diagnosing whether a subject is at risk for recunent prostate carcinoma after prostatectomy comprising determining the amount of at least one metabolite selected from Table 2 in a test sample of a subject after prostatectomy, and comparing the determined amount to a reference, whereby it is diagnosed whether the subject is at risk for recurrent prostate carcinoma after prostatectomy. Further methods provided in accordance with the present invention relate to differentiating between a malignant prostate carcinoma tissue and a non-malignant tissue and diagnosing metastasizing prostate carcinoma in a subject. Also provided are devices for carrying out the aforementioned methods.Type: ApplicationFiled: October 2, 2013Publication date: August 27, 2015Applicants: Charité Universitätsmedizin Berlin, Metanomics Health GmbHInventors: Regina Reszka, Beate Kamlage, Bianca Bethan, Klaus Jung, Michael Lein, Glen Kristiansen, Carsten Stephan
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Publication number: 20150160238Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject and a method for monitoring progression or regression of heart failure in a subject. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: ApplicationFiled: July 27, 2012Publication date: June 11, 2015Applicants: RUPRECHT-KARLS-UNIVERISTÄT HEIDELBERG, METANOMICS GMBHInventors: Regina Reszka, Jens Fuhrmann, Jürgen Kastler, Bianca Bethan, Martin Kluttig, Hugo A. Katus, Norbert Frey, Johanna Wolf, Tanja Weis
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Publication number: 20140323352Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing pancreatic cancer in a subject, a method for identifying whether a subject is in need for a therapy of pancreatic cancer or a method for determining whether a pancreatic cancer therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: ApplicationFiled: November 29, 2012Publication date: October 30, 2014Applicant: METANOMICS HEALTH GMBHInventors: Regina Reszka, Beate Kamlage, Holger Kalthoff, Bodo Schniewind, Julia Mayerle, Markus M. Lerch, Christian Pilarsky, Robert Grützmann
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Publication number: 20130140452Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing pancreatic cancer in a subject, a method for identifying whether a subject is in need for a therapy of pancreatic cancer or a method for determining whether a pancreatic cancer therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: ApplicationFiled: May 26, 2011Publication date: June 6, 2013Inventors: Beate Kamlage, Regina Reszka, Martin Kluttig, Holger Kalthoff, Bodo Schniewind, Julia Mayerie, Markus Lerch
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Publication number: 20120286157Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject, a method for identifying whether a subject is in need for a therapy of heart failure or a method for determining whether a heart failure therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: ApplicationFiled: January 28, 2011Publication date: November 15, 2012Applicants: Rupreht-Karls-Universitat Heidelberg, Metanomics GmbHInventors: Jens Fuhrmann, Regina Reszka, Jürgen Kastler, Kristina Busch, Edgar Leibold, Hugo Katus, Norbert Frey, Johanna Wolf, Tanja Weis
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Publication number: 20120238028Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing multiple sclerosis in a subject, a method for identifying whether a subject is in need for a therapy of multiple sclerosis or a method for determining whether a multiple sclerosis therapy is successful. Moreover, contributed is a method for diagnosing or predicting the risk of an active status of multiple sclerosis in a subject. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: ApplicationFiled: November 30, 2010Publication date: September 20, 2012Applicant: Metanomics Health GmbHInventors: Regina Reszka, Ulrike Rennefahrt, Andreas Hewelt, Jürgen Kastler, Jens Fuhrmann, Frauke Zipp, Carmen Infante-Duarte
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Publication number: 20120122243Abstract: The present invention relates to a method, preferably an ex vivo method, for diagnosing prostate carcinomas and/or predisposition thereof comprising determining at least one metabolite in a test sample of a subject suspected to suffer from prostate carcinomas or to have a predisposition therefor and comparing said at least one metabolite to a reference, whereby prostate carcinomas or a predisposition therefor is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium.Type: ApplicationFiled: June 2, 2010Publication date: May 17, 2012Applicants: CHARITE UNIVERSITATSMEDIZIN BERLIN, METANOMICS HEALTH GMBHInventors: Beate Kamlage, Bianca Bethan, Regina Reszka, Edgar Leibold, Klaus Jung, Michael Lein, Glen Kristiansen
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Patent number: 7556827Abstract: The invention relates to an implantable active ingredient depot for therapeutically active substances. The fields of application are in medicine and the pharmaceutical industry. The implantable active ingredient depot is constituted of a lipid matrix capable of forming cubic phases into which modifier molecules have been integrated and contains pharmaceutically active substances. A preferred lipid matrix is monooleine. The implantable depot of the invention is useful for the treatment of tumors in oncological therapy and in gene therapy. A rational membrane design allows control of the release of the active ingredients over time and also control of the amount released.Type: GrantFiled: August 4, 2000Date of Patent: July 7, 2009Assignee: Max-Delbrück-Centrum-für Molekulare MedizinInventors: Regina Reszka, Roland Schluter
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Patent number: 7462703Abstract: An agent for the transfer of genetic material comprising a genetic material, PEG-containing liposomes, one or more additional polymer particles and a contrasting agent. The invention also is directed toward methods of preparing the agent, and methods of using the agent to affect gene transfer.Type: GrantFiled: January 31, 2003Date of Patent: December 9, 2008Assignee: Max-Delbruck-Centrum fur Molekulare MedizinInventors: Regina Reszka, Antje Berndt
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Publication number: 20050196345Abstract: The invention relates to a compressed air inhaler for the pulmonary application of a liposomal powder aerosol that carries active agents or is uncharged.Type: ApplicationFiled: April 21, 2005Publication date: September 8, 2005Applicants: Max-Delbruck-Centrum fur Molekulare Medizin, Fraunhofer-Gesellschaft zur Forderung der Angewandten Forschung E.V.Inventors: Julia Diederichs, Wolfgang Koch, Hubert Lodding, Regina Reszka, Horst Windt
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Publication number: 20050019386Abstract: The invention relates to pharmaceutical preparations suitable for oral application of liposomally encapsulated Taxol, its derivatives and Taxan. Preferably, they additionally contain at least one immuno-modulator, preferably Cyclosporine, and/or at least one cytokine, preferably PEG cytokines.Type: ApplicationFiled: November 6, 2002Publication date: January 27, 2005Inventors: Regina Reszka, Iduna Fichtner