Patents by Inventor Regis Jean Georges Mondiere

Regis Jean Georges Mondiere has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11999749
    Abstract: A manufacturing process to a bis-mesylate salt 1b of the pan-RAF inhibitor 4-amino-n-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide. The process features a number of efficient key reactions, including a robust and scalable Pd-catalyzed carbonylation reaction to generate thienopyrimidine 2 and a highly chemoselective Pt/V/C-catalyzed nitro group reduction to access penultimate intermediate 7. The final amide coupling of 7 and 2 was accomplished by a mild and safe protocol employing N,N,N?,N?-tetramethylchloroformamidinium hexafluorophosphate (TCFH) as the coupling reagent, to produce a 1:1 adduct of the freebase and THF. The adduct afforded compound 1b with excellent yield, purity, and form stability on a multikilogram production scale after reaction with MsOH and recrystallization. The methods are able to produce a compound having upwards of 95% purity.
    Type: Grant
    Filed: June 28, 2022
    Date of Patent: June 4, 2024
    Assignees: Genentech, Inc., Hoffmann-La Roche Inc.
    Inventors: Francis Gosselin, Stefan G. Koenig, Eduardo V. Mercado-Marin, Andreas Stumpf, Daniel Zell, Haiming Zhang, Stephan Bachmann, Diane E. Carrera, Michael E. Dalziel, Yonghui Ge, Jie Zhang, Raphael Bigler, Laure Elizabeth Simone Finet, Regis Jean Georges Mondiere, Yuki Nakagawa
  • Publication number: 20240150291
    Abstract: The present invention relates to intermediates and processes useful for preparing 1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide and salts thereof. The present invention further relates to 1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide and salts thereof when prepared by such processes and to associated pharmaceutical compositions and uses for the treatment and prevention of medical disorders and diseases, most especially by NLRP3 inhibition.
    Type: Application
    Filed: December 19, 2023
    Publication date: May 9, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Paul FRASER, Jetta PALGUNA, Mallesh BHARATHA, Joséphine Eliette Françoise CINQUALBRE, Régis Jean Georges MONDIÈRE, Paolo TOSATTI
  • Publication number: 20230028651
    Abstract: A manufacturing process to a bis-mesylate salt 1b of the pan-RAF inhibitor 4-amino-n-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide. The process features a number of efficient key reactions, including a robust and scalable Pd-catalyzed carbonylation reaction to generate thienopyrimidine 2 and a highly chemoselective PtN/C-catalyzed nitro group reduction to access penultimate intermediate 7. The final amide coupling of 7 and 2 was accomplished by a mild and safe protocol employing N,N,N?,N?-tetramethylchloroformamidinium hexafluorophosphate (TCFH) as the coupling reagent, to produce a 1:1 adduct of the freebase and THF. The adduct afforded compound 1b with excellent yield, purity, and form stability on a multikilogram production scale after reaction with MsOH and recrystallization. The methods are able to produce a compound having upwards of 95% purity.
    Type: Application
    Filed: June 28, 2022
    Publication date: January 26, 2023
    Applicants: Genentech, Inc., Hoffmann-La Roche Inc.
    Inventors: Francis GOSSELIN, Stefan G. KOENIG, Eduardo V. MERCADO-MARIN, Andreas STUMPF, Daniel ZELL, Haiming ZHANG, Stephan BACHMANN, Diane E. CARRERA, Michael E. DALZIEL, Yonghui GE, Jie ZHANG, Raphael BIGLER, Laure Elizabeth Simone FINET, Regis Jean Georges MONDIERE, Yuki NAKAGAWA
  • Patent number: 11472797
    Abstract: Compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: October 18, 2022
    Assignee: SYNGENTA PARTICIPATIONS AG
    Inventors: Myriem El Qacemi, Aurelien Bigot, Andrew Edmunds, Julien Daniel Henri Gagnepain, André Jeanguenat, Thomas Pitterna, André Stoller, Davide Sabbadin, Regis Jean Georges Mondiere, Denis Gribkov
  • Publication number: 20220194907
    Abstract: The present invention relates to a process according to Scheme 1 for the preparation of microbiocidal 5-trifluoromethyl-1,2,4-oxadiazole derivatives of formula (I) suitable for use, e.g., as active ingredients, which have microbiocidal activity, in particular, fungicidal activity.
    Type: Application
    Filed: April 16, 2020
    Publication date: June 23, 2022
    Applicant: SYNGENTA CROP PROTECTION AG
    Inventors: Thomas James HOFFMAN, Regis Jean Georges MONDIERE, Edouard GODINEAU, Wolfgang STUTZ, Sujit Kumar GHORAI, Anup JAWALEKAR
  • Patent number: 11142519
    Abstract: Compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: October 12, 2021
    Assignee: SYNGENTA PARTICIPATIONS AG
    Inventors: Myriem El Qacemi, Aurelien Bigot, Andrew Edmunds, Julien Daniel Henri Gagnepain, André Jeanguenat, Thomas Pitterna, André Stoller, Davide Sabbadin, Regis Jean Georges Mondiere, Denis Gribkov
  • Patent number: 11040962
    Abstract: Compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: June 22, 2021
    Assignee: SYNGENTA PARTICIPATIONS AG
    Inventors: Myriem El Qacemi, Aurelien Bigot, Andrew Edmunds, Julien Daniel Henri Gagnepain, André Jeanguenat, Thomas Pitterna, André Stoller, Davide Sabbadin, Regis Jean Georges Mondiere, Denis Gribkov
  • Patent number: 10961248
    Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.
    Type: Grant
    Filed: November 24, 2017
    Date of Patent: March 30, 2021
    Assignee: SYNGENTA PARTICIPATIONS AG
    Inventors: Andrew Edmunds, Michel Muehlebach, Pierre Joseph Marcel Jung, Sebastian Rendler, Vikas Sikervar, Girish Rawal, Indira Sen, Régis Jean Georges Mondiere, Tomas Smejkal, Myriem El Qacemi, Denis Gribkov
  • Patent number: 10952435
    Abstract: Compounds of the formula (I), in which the substituents are as defined in claim 1, are suitable for use as nematicides.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: March 23, 2021
    Assignee: SYNGENTA PARTICIPATIONS AG
    Inventors: Olivier Loiseleur, Andre Jeanguenat, Regis Jean Georges Mondiere
  • Publication number: 20210009573
    Abstract: Compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.
    Type: Application
    Filed: April 4, 2018
    Publication date: January 14, 2021
    Applicant: SYNGENTA PARTICIPATIONS AG
    Inventors: Myriem EL QACEMI, Aurelien BIGOT, Andrew EDMUNDS, Julien Daniel Henri GAGNEPAIN, André JEANGUENAT, Thomas PITTERNA, André STOLLER, Davide SABBADIN, Regis Jean Georges MONDIERE, Denis GRIBKOV
  • Patent number: 10874104
    Abstract: Compounds of formula (I), as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: December 29, 2020
    Assignee: SYNGENTA PARTICIPATIONS AG
    Inventors: André Jeanguenat, Thomas Pitterna, Myriem El Qacemi, André Stoller, Régis Jean Georges Mondiere, Aurelien Bigot, Andrew Edmunds, Denis Gribkov
  • Patent number: 10750742
    Abstract: Compounds of formula (I), as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: August 25, 2020
    Assignee: Syngenta Participations AG
    Inventors: André Jeanguenat, Myriem El Qacemi, Thomas Pitterna, André Stoller, Regis Jean Georges Mondiere, Aurelien Bigot, Andrew Edmunds
  • Publication number: 20200048238
    Abstract: Compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.
    Type: Application
    Filed: April 4, 2018
    Publication date: February 13, 2020
    Applicant: SYNGENTA PARTICIPATIONS AG
    Inventors: Myriem EL QACEMI, Aurelien BIGOT, Andrew EDMUNDS, Julien Daniel Henri GAGNEPAIN, André JEANGUENAT, Thomas PITTERNA, André STOLLER, Davide SABBADIN, Regis Jean Georges MONDIERE, Denis GRIBKOV
  • Publication number: 20200031814
    Abstract: Compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.
    Type: Application
    Filed: April 4, 2018
    Publication date: January 30, 2020
    Applicant: SYNGENTA PARTICIPATIONS AG
    Inventors: Myriem EL QACEMI, Aurelien BIGOT, Andrew EDMUNDS, Julien Daniel Henri GAGNEPAIN, André JEANGUENAT, Thomas PITTERNA, André STOLLER, Davide SABBADIN, Regis Jean Georges MONDIERE, Denis GRIBKOV
  • Publication number: 20190322675
    Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.
    Type: Application
    Filed: November 24, 2017
    Publication date: October 24, 2019
    Applicant: SYNGENTA PARTICIPATIONS AG
    Inventors: Andrew EDMUNDS, Michel MUEHLEBACH, Pierre Joseph Marcel JUNG, Sebastian RENDLER, Vikas SIKERVAR, Girish RAWAL, Indira SEN, Régis Jean Georges MONDIERE, Tomas SMEJKAL, Sujit Kumar GHORAI, Denis GRIBKOV
  • Publication number: 20190150441
    Abstract: Compounds of formula (I), as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.
    Type: Application
    Filed: February 16, 2017
    Publication date: May 23, 2019
    Applicant: SYNGENTA PARTICIPATIONS AG
    Inventors: André Jeanguenat, Thomas Pitterna, Myriem El Qacemi, André Stoller, Régis Jean Georges Mondiere, Aurelien Bigot, Andrew Edmunds, Denis Gribkov
  • Patent number: 10207985
    Abstract: Compounds of the formula in which the substituents are as defined in claim 1, are suitable for use as nematicides.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: February 19, 2019
    Assignee: SYNGENTA PARTICIPATIONS AG
    Inventors: Regis Jean Georges Mondiere, Olivier Loiseleur, Andre Jeanguenat, Anthony Cornelius O'Sulivan
  • Publication number: 20190014783
    Abstract: Compounds of formula (I), as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.
    Type: Application
    Filed: December 15, 2016
    Publication date: January 17, 2019
    Applicant: SYNGENTA PARTICIPATIONS AG
    Inventors: André Jeanguenat, Myriem El Qacemi, Thomas Pitterna, André Stoller, Regis Jean Georges Mondiere, Aurelien Bigot, Andrew Edmunds
  • Patent number: 10093672
    Abstract: A process for making certain spiroheterocyclic pyrrolidine dione derivatives.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: October 9, 2018
    Assignee: SYNGENTA PARTICIPATIONS AG
    Inventors: Edouard Godineau, Tomas Smejkal, Sophie Pelletier, Michel Muehlebach, Régis Jean Georges Mondiere, Helmars Smits, Jochen Weckesser, Alan James Robinson
  • Publication number: 20180237437
    Abstract: A process for making certain spiroheterocyclic pyrrolidine dione derivatives.
    Type: Application
    Filed: April 20, 2018
    Publication date: August 23, 2018
    Applicant: SYNGENTA PARTICIPATIONS AG
    Inventors: Edouard Godineau, Tomas Smejkal, Sophie Pelletier, Michel Muehlebach, Régis Jean Georges Mondiere, Helmars Smits, Jochen Weckesser, Alan James Robinson