Patents by Inventor Regis Jean Georges Mondiere
Regis Jean Georges Mondiere has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11999749Abstract: A manufacturing process to a bis-mesylate salt 1b of the pan-RAF inhibitor 4-amino-n-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide. The process features a number of efficient key reactions, including a robust and scalable Pd-catalyzed carbonylation reaction to generate thienopyrimidine 2 and a highly chemoselective Pt/V/C-catalyzed nitro group reduction to access penultimate intermediate 7. The final amide coupling of 7 and 2 was accomplished by a mild and safe protocol employing N,N,N?,N?-tetramethylchloroformamidinium hexafluorophosphate (TCFH) as the coupling reagent, to produce a 1:1 adduct of the freebase and THF. The adduct afforded compound 1b with excellent yield, purity, and form stability on a multikilogram production scale after reaction with MsOH and recrystallization. The methods are able to produce a compound having upwards of 95% purity.Type: GrantFiled: June 28, 2022Date of Patent: June 4, 2024Assignees: Genentech, Inc., Hoffmann-La Roche Inc.Inventors: Francis Gosselin, Stefan G. Koenig, Eduardo V. Mercado-Marin, Andreas Stumpf, Daniel Zell, Haiming Zhang, Stephan Bachmann, Diane E. Carrera, Michael E. Dalziel, Yonghui Ge, Jie Zhang, Raphael Bigler, Laure Elizabeth Simone Finet, Regis Jean Georges Mondiere, Yuki Nakagawa
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Publication number: 20240150291Abstract: The present invention relates to intermediates and processes useful for preparing 1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide and salts thereof. The present invention further relates to 1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide and salts thereof when prepared by such processes and to associated pharmaceutical compositions and uses for the treatment and prevention of medical disorders and diseases, most especially by NLRP3 inhibition.Type: ApplicationFiled: December 19, 2023Publication date: May 9, 2024Applicant: Hoffmann-La Roche Inc.Inventors: Paul FRASER, Jetta PALGUNA, Mallesh BHARATHA, Joséphine Eliette Françoise CINQUALBRE, Régis Jean Georges MONDIÈRE, Paolo TOSATTI
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Publication number: 20230028651Abstract: A manufacturing process to a bis-mesylate salt 1b of the pan-RAF inhibitor 4-amino-n-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide. The process features a number of efficient key reactions, including a robust and scalable Pd-catalyzed carbonylation reaction to generate thienopyrimidine 2 and a highly chemoselective PtN/C-catalyzed nitro group reduction to access penultimate intermediate 7. The final amide coupling of 7 and 2 was accomplished by a mild and safe protocol employing N,N,N?,N?-tetramethylchloroformamidinium hexafluorophosphate (TCFH) as the coupling reagent, to produce a 1:1 adduct of the freebase and THF. The adduct afforded compound 1b with excellent yield, purity, and form stability on a multikilogram production scale after reaction with MsOH and recrystallization. The methods are able to produce a compound having upwards of 95% purity.Type: ApplicationFiled: June 28, 2022Publication date: January 26, 2023Applicants: Genentech, Inc., Hoffmann-La Roche Inc.Inventors: Francis GOSSELIN, Stefan G. KOENIG, Eduardo V. MERCADO-MARIN, Andreas STUMPF, Daniel ZELL, Haiming ZHANG, Stephan BACHMANN, Diane E. CARRERA, Michael E. DALZIEL, Yonghui GE, Jie ZHANG, Raphael BIGLER, Laure Elizabeth Simone FINET, Regis Jean Georges MONDIERE, Yuki NAKAGAWA
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Patent number: 11472797Abstract: Compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.Type: GrantFiled: April 4, 2018Date of Patent: October 18, 2022Assignee: SYNGENTA PARTICIPATIONS AGInventors: Myriem El Qacemi, Aurelien Bigot, Andrew Edmunds, Julien Daniel Henri Gagnepain, André Jeanguenat, Thomas Pitterna, André Stoller, Davide Sabbadin, Regis Jean Georges Mondiere, Denis Gribkov
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Publication number: 20220194907Abstract: The present invention relates to a process according to Scheme 1 for the preparation of microbiocidal 5-trifluoromethyl-1,2,4-oxadiazole derivatives of formula (I) suitable for use, e.g., as active ingredients, which have microbiocidal activity, in particular, fungicidal activity.Type: ApplicationFiled: April 16, 2020Publication date: June 23, 2022Applicant: SYNGENTA CROP PROTECTION AGInventors: Thomas James HOFFMAN, Regis Jean Georges MONDIERE, Edouard GODINEAU, Wolfgang STUTZ, Sujit Kumar GHORAI, Anup JAWALEKAR
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Patent number: 11142519Abstract: Compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.Type: GrantFiled: April 4, 2018Date of Patent: October 12, 2021Assignee: SYNGENTA PARTICIPATIONS AGInventors: Myriem El Qacemi, Aurelien Bigot, Andrew Edmunds, Julien Daniel Henri Gagnepain, André Jeanguenat, Thomas Pitterna, André Stoller, Davide Sabbadin, Regis Jean Georges Mondiere, Denis Gribkov
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Patent number: 11040962Abstract: Compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.Type: GrantFiled: April 4, 2018Date of Patent: June 22, 2021Assignee: SYNGENTA PARTICIPATIONS AGInventors: Myriem El Qacemi, Aurelien Bigot, Andrew Edmunds, Julien Daniel Henri Gagnepain, André Jeanguenat, Thomas Pitterna, André Stoller, Davide Sabbadin, Regis Jean Georges Mondiere, Denis Gribkov
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Patent number: 10961248Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.Type: GrantFiled: November 24, 2017Date of Patent: March 30, 2021Assignee: SYNGENTA PARTICIPATIONS AGInventors: Andrew Edmunds, Michel Muehlebach, Pierre Joseph Marcel Jung, Sebastian Rendler, Vikas Sikervar, Girish Rawal, Indira Sen, Régis Jean Georges Mondiere, Tomas Smejkal, Myriem El Qacemi, Denis Gribkov
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Patent number: 10952435Abstract: Compounds of the formula (I), in which the substituents are as defined in claim 1, are suitable for use as nematicides.Type: GrantFiled: July 11, 2014Date of Patent: March 23, 2021Assignee: SYNGENTA PARTICIPATIONS AGInventors: Olivier Loiseleur, Andre Jeanguenat, Regis Jean Georges Mondiere
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Publication number: 20210009573Abstract: Compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.Type: ApplicationFiled: April 4, 2018Publication date: January 14, 2021Applicant: SYNGENTA PARTICIPATIONS AGInventors: Myriem EL QACEMI, Aurelien BIGOT, Andrew EDMUNDS, Julien Daniel Henri GAGNEPAIN, André JEANGUENAT, Thomas PITTERNA, André STOLLER, Davide SABBADIN, Regis Jean Georges MONDIERE, Denis GRIBKOV
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Patent number: 10874104Abstract: Compounds of formula (I), as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.Type: GrantFiled: February 16, 2017Date of Patent: December 29, 2020Assignee: SYNGENTA PARTICIPATIONS AGInventors: André Jeanguenat, Thomas Pitterna, Myriem El Qacemi, André Stoller, Régis Jean Georges Mondiere, Aurelien Bigot, Andrew Edmunds, Denis Gribkov
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Patent number: 10750742Abstract: Compounds of formula (I), as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.Type: GrantFiled: December 15, 2016Date of Patent: August 25, 2020Assignee: Syngenta Participations AGInventors: André Jeanguenat, Myriem El Qacemi, Thomas Pitterna, André Stoller, Regis Jean Georges Mondiere, Aurelien Bigot, Andrew Edmunds
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Publication number: 20200048238Abstract: Compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.Type: ApplicationFiled: April 4, 2018Publication date: February 13, 2020Applicant: SYNGENTA PARTICIPATIONS AGInventors: Myriem EL QACEMI, Aurelien BIGOT, Andrew EDMUNDS, Julien Daniel Henri GAGNEPAIN, André JEANGUENAT, Thomas PITTERNA, André STOLLER, Davide SABBADIN, Regis Jean Georges MONDIERE, Denis GRIBKOV
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Publication number: 20200031814Abstract: Compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.Type: ApplicationFiled: April 4, 2018Publication date: January 30, 2020Applicant: SYNGENTA PARTICIPATIONS AGInventors: Myriem EL QACEMI, Aurelien BIGOT, Andrew EDMUNDS, Julien Daniel Henri GAGNEPAIN, André JEANGUENAT, Thomas PITTERNA, André STOLLER, Davide SABBADIN, Regis Jean Georges MONDIERE, Denis GRIBKOV
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Publication number: 20190322675Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.Type: ApplicationFiled: November 24, 2017Publication date: October 24, 2019Applicant: SYNGENTA PARTICIPATIONS AGInventors: Andrew EDMUNDS, Michel MUEHLEBACH, Pierre Joseph Marcel JUNG, Sebastian RENDLER, Vikas SIKERVAR, Girish RAWAL, Indira SEN, Régis Jean Georges MONDIERE, Tomas SMEJKAL, Sujit Kumar GHORAI, Denis GRIBKOV
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Publication number: 20190150441Abstract: Compounds of formula (I), as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.Type: ApplicationFiled: February 16, 2017Publication date: May 23, 2019Applicant: SYNGENTA PARTICIPATIONS AGInventors: André Jeanguenat, Thomas Pitterna, Myriem El Qacemi, André Stoller, Régis Jean Georges Mondiere, Aurelien Bigot, Andrew Edmunds, Denis Gribkov
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Patent number: 10207985Abstract: Compounds of the formula in which the substituents are as defined in claim 1, are suitable for use as nematicides.Type: GrantFiled: August 8, 2014Date of Patent: February 19, 2019Assignee: SYNGENTA PARTICIPATIONS AGInventors: Regis Jean Georges Mondiere, Olivier Loiseleur, Andre Jeanguenat, Anthony Cornelius O'Sulivan
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Publication number: 20190014783Abstract: Compounds of formula (I), as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.Type: ApplicationFiled: December 15, 2016Publication date: January 17, 2019Applicant: SYNGENTA PARTICIPATIONS AGInventors: André Jeanguenat, Myriem El Qacemi, Thomas Pitterna, André Stoller, Regis Jean Georges Mondiere, Aurelien Bigot, Andrew Edmunds
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Patent number: 10093672Abstract: A process for making certain spiroheterocyclic pyrrolidine dione derivatives.Type: GrantFiled: April 20, 2018Date of Patent: October 9, 2018Assignee: SYNGENTA PARTICIPATIONS AGInventors: Edouard Godineau, Tomas Smejkal, Sophie Pelletier, Michel Muehlebach, Régis Jean Georges Mondiere, Helmars Smits, Jochen Weckesser, Alan James Robinson
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Publication number: 20180237437Abstract: A process for making certain spiroheterocyclic pyrrolidine dione derivatives.Type: ApplicationFiled: April 20, 2018Publication date: August 23, 2018Applicant: SYNGENTA PARTICIPATIONS AGInventors: Edouard Godineau, Tomas Smejkal, Sophie Pelletier, Michel Muehlebach, Régis Jean Georges Mondiere, Helmars Smits, Jochen Weckesser, Alan James Robinson