Patents by Inventor Regis Peytavi
Regis Peytavi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11713455Abstract: For enhanced selection of efficient targeted genome manipulating agents, an apparatus includes first and second chip-based biosensors having one or more sensing surfaces configured to detect biomolecular binding interactions between a nucleic acid sample and a targeted genome manipulating agent functionalized to a capture surface within a sensing range of the one or more sensing surfaces. The first chip-based biosensor uses a nucleic acid sample incubated with a blocking agent that blocks on-target binding and the second chip-based biosensor holds a nucleic acid sample that omits the blocking agent. A measurement apparatus measures first and second sets of response signals produced in response to the biomolecular binding interactions occurring between the nucleic acid sample and the targeted genome manipulating agent. An analysis module determines the genome manipulating efficiency parameters of the targeted genome manipulating agent. A system and a method perform the functions of the apparatus.Type: GrantFiled: February 5, 2020Date of Patent: August 1, 2023Assignee: Cardea Bio, Inc.Inventors: Regis Peytavi, Kiana Aran, Brett Goldsmith, Alexander Kane
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Publication number: 20210382045Abstract: Apparatuses, systems, and methods are disclosed for excitation and measurement of biochemical interactions. Excitation circuitry is configured to apply one or more excitation conditions to a biologically gated transistor that includes a channel, so that one or more output signals from the biologically gated transistor are affected by the excitation condition(s) and by a biochemical interaction of moieties within a sample fluid in contact with the channel surface. Measurement circuitry is configured to obtain information corresponding to the biochemical interaction occurring at one or more measurement distances greater than an electrostatic screening distance from the surface of the channel, by performing a plurality of time-dependent measurements of affected output signals, using a measurement bandwidth that corresponds to the measurement distances. An analysis module is configured to characterize one or more parameters of the biochemical interaction based on the time-dependent measurements.Type: ApplicationFiled: June 8, 2021Publication date: December 9, 2021Inventors: Kiana Aran, Brett Goldsmith, Alexander Kane, Regis Peytavi
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Patent number: 11123730Abstract: A fluidic centripetal apparatus for testing components of a biological material in a fluid is presented. The fluidic centripetal device is adapted to be received within a rotatable holder. The apparatus comprises a fluidic component layer having fluidic features on at least a front face and a bottom component layer bonded to a rear of the fluidic component layer thereby creating a fluidic network through which the fluid flows under centripetal force. In one embodiment, the fluidic feature may be a bottom-Tillable chamber coupled to an entry channel for receiving the fluid, the chamber inlet being provided at an outer side of the bottom-fillable chamber.Type: GrantFiled: September 30, 2019Date of Patent: September 21, 2021Assignees: Universite Laval, Meridian Bioscience Canada Inc.Inventors: Régis Peytavi, Sébastien Chapdelaine
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Publication number: 20200061607Abstract: A fluidic centripetal apparatus for testing components of a biological material in a fluid is presented. The fluidic centripetal device is adapted to be received within a rotatable holder. The apparatus comprises a fluidic component layer having fluidic features on at least a front face and a bottom component layer bonded to a rear of the fluidic component layer thereby creating a fluidic network through which the fluid flows under centripetal force. In one embodiment, the fluidic feature may be a bottom-Tillable chamber coupled to an entry channel for receiving the fluid, the chamber inlet being provided at an outer side of the bottom-fillable chamber.Type: ApplicationFiled: September 30, 2019Publication date: February 27, 2020Inventors: Régis Peytavi, Sébastien Chapdelaine
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Patent number: 10427158Abstract: A fluidic centripetal apparatus for testing components of a biological material in a fluid is presented. The fluidic centripetal device is adapted to be received within a rotatable holder. The apparatus comprises a fluidic component layer having fluidic features on at least a front face and a bottom component layer bonded to a rear of the fluidic component layer thereby creating a fluidic network through which the fluid flows under centripetal force. In one embodiment, the fluidic feature may be a bottom-fillable chamber coupled to an entry channel for receiving the fluid, the chamber inlet being provided at an outer side of the bottom-fillable chamber.Type: GrantFiled: September 9, 2016Date of Patent: October 1, 2019Assignees: UNIVERSITÉ LAVAL, Meridian Bioscience Canada Inc.Inventors: Régis Peytavi, Sébastien Chapdelaine
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Publication number: 20170056878Abstract: A fluidic centripetal apparatus for testing components of a biological material in a fluid is presented. The fluidic centripetal device is adapted to be received within a rotatable holder. The apparatus comprises a fluidic component layer having fluidic features on at least a front face and a bottom component layer bonded to a rear of the fluidic component layer thereby creating a fluidic network through which the fluid flows under centripetal force. In one embodiment, the fluidic feature may be a bottom-fillable chamber coupled to an entry channel for receiving the fluid, the chamber inlet being provided at an outer side of the bottom-fillable chamber.Type: ApplicationFiled: September 9, 2016Publication date: March 2, 2017Inventors: Régis Peytavi, Sébastien Chapdelaine
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Patent number: 9562262Abstract: A fluidic centripetal apparatus for testing components of a biological material in a fluid is presented. A bottom-fillable chamber is coupled to an entry channel for receiving the fluid, the chamber inlet being provided at an outer side of the bottom-fillable chamber. A container is wholly provided in a retention chamber and contains a liquid diluent, until it releases it upon application of an external force, restoring the fluidic connection between the liquid diluent and the fluid in the retention chamber. The retention chamber can have a flow decoupling receptacle for receiving the fluid, located at the outer side of the retention chamber and interrupting a fluidic connection between the entry and exit of the retention chamber. A test apparatus and a testing method using a fluidic centripetal device for testing components of a biological material in a fluid are also provided.Type: GrantFiled: March 7, 2012Date of Patent: February 7, 2017Assignees: Université Laval, Genepoc Inc.Inventors: Régis Peytavi, Sébastien Chapdelaine
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Publication number: 20150031577Abstract: Reagents, systems and methods for the detection of nucleic acids are described herein, including such methods which may be performed in a single reaction. Such reagents include a target specific indexing probe (TSIP) synthetic DNA structure comprising a detectable moiety and a quencher thereof, wherein in the presence of a target nucleic acid a portion (a tag) of the (TSIP) synthetic DNA structure comprising the detectable moiety is released, thereby increasing the signal emitted therefrom. The tag may in turn bind to a capture probe, facilitating signal detection.Type: ApplicationFiled: March 20, 2013Publication date: January 29, 2015Inventors: Karel Boissinot, Régis Peytavi, Laurie Girard
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Publication number: 20130344496Abstract: A fluidic centripetal apparatus for testing components of a biological material in a fluid is presented. A bottom-fillable chamber is coupled to an entry channel for receiving the fluid, the chamber inlet being provided at an outer side of the bottom-fillable chamber. A container is wholly provided in a retention chamber and contains a liquid diluent, until it releases it upon application of an external force, restoring the fluidic connection between the liquid diluent and the fluid in the retention chamber. The retention chamber can have a flow decoupling receptacle for receiving the fluid, located at the outer side of the retention chamber and interrupting a fluidic connection between the entry and exit of the retention chamber. A test apparatus and a testing method using a fluidic centripetal device for testing components of a biological material in a fluid are also provided.Type: ApplicationFiled: March 7, 2012Publication date: December 26, 2013Inventors: Régis Peytavi, Sébastien Chapdelaine
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Patent number: 8534319Abstract: Methods and devices using a co-radial arrangement of serial siphon structures composed of siphon valves each separated by a capillary valve to save radial space in a fluidic system. Such serial siphon valves allow to sequentially distribute liquids in a fluidic system upon application of successive centripetal accelerations and decelerations applied to a rotary platform.Type: GrantFiled: March 3, 2008Date of Patent: September 17, 2013Assignees: Universite Laval, The Regents of the University of CaliforniaInventors: Michel G. Bergeron, Regis Peytavi, Horacio Kido, Marc Madou
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Patent number: 8481265Abstract: The present invention relates to a method for isolating microorganisms and/or microorganisms nucleic acids from a bodily fluid that may comprise or may be suspected to comprise microorganisms and/or host cells and/or host cells debris. Microorganisms nucleic acids may further be isolated by lysing the isolated microorganisms. The present invention also relates to a method for detecting microorganisms in a bodily fluid. The present invention further relates to a saponin formulation and its use.Type: GrantFiled: August 1, 2008Date of Patent: July 9, 2013Assignee: Universite LavalInventors: Régis Peytavi, Ann Huletsky, Lucile Belley-Montfort, Isabelle Martineau
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Patent number: 8444934Abstract: A microfluidic flow cell for removably interfacing with a removable-member for performing a reaction therebetween. The microfluidic flow cell device comprises at least one reaction portion defining with the removable-member a reaction chamber when in an interfaced position thereof. The microfluidic flow cell comprises at least one fluid-receiving portion for receiving a fluid therein and being in fluid communication with the reaction chamber. When the microfluidic flow cell and the removable-member are in the interfaced position, the cell is adapted to allow for the fluid in the fluid-receiving portion to flow to the reaction chamber. Devices, systems and methods comprising this microfluidic flow cell are also disclosed.Type: GrantFiled: March 29, 2005Date of Patent: May 21, 2013Assignee: Universite LavalInventor: Regis Peytavi
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Patent number: 8303911Abstract: A microfluidic system for processing a sample includes a microfluidic CD in the form a rotatable disc, the disc containing a plurality of separate lysis chambers therein. A magnetic lysis blade and lysis beads are disposed in each of the lysis chambers and a plurality of stationary magnets are disposed adjacent to and separate from the microfluidic CD. The stationary magnets are configured to magnetically interact with each of the magnetic lysis blades upon rotation of the microfluidic CD. Each lysis chamber may have its own separate sample inlet port or, alternatively, the lysis chambers may be connected to one another with a single inlet port coupled to one of the lysis chambers. Downstream processing may include nucleic acid amplification using thermoelectric heating as well as detection using a nucleic acid microarray.Type: GrantFiled: October 14, 2010Date of Patent: November 6, 2012Assignee: The Regents of the University of CaliforniaInventors: Jonathan P. Siegrist, Robert A. Gorkin, III, Regis Peytavi, Marc Madou, Horacio Kido, Mary Amasia, Emmanuel Roy, Teodor Veres
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Publication number: 20110294128Abstract: The present invention relates to a method for isolating microorganisms and/or microorganisms nucleic acids from a bodily fluid that may comprise or may be suspected to comprise microorganisms and/or host cells and/or host cells debris. Microorganisms nucleic acids may further be isolated by lysing the isolated microorganisms. The present invention also relates to a method for detecting microorganisms in a bodily fluid. The present invention further relates to a saponin formulation and its use.Type: ApplicationFiled: August 1, 2008Publication date: December 1, 2011Applicant: Universite LavalInventors: Régis Peytavi, Ann Huletsky, Lucile Belley-Montfort, Isabelle Martineau
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Publication number: 20110111987Abstract: A microfluidic system for processing a sample includes a microfluidic CD in the form a rotatable disc, the disc containing a plurality of separate lysis chambers therein. A magnetic lysis blade and lysis beads are disposed in each of the lysis chambers and a plurality of stationary magnets are disposed adjacent to and separate from the microfluidic CD. The stationary magnets are configured to magnetically interact with each of the magnetic lysis blades upon rotation of the microfluidic CD. Each lysis chamber may have its own separate sample inlet port or, alternatively, the lysis chambers may be connected to one another with a single inlet port coupled to one of the lysis chambers. Downstream processing may include nucleic acid amplification using thermoelectric heating as well as detection using a nucleic acid microarray.Type: ApplicationFiled: October 14, 2010Publication date: May 12, 2011Inventors: Jonathan Siegrist, Robert A. Gorkin, III, Regis Peytavi, Marc Madou, Horacio Kido, Mary Amasia, Emmanuel Roy, Teodor Veres
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Publication number: 20110094600Abstract: Methods and devices using a co-radial arrangement of serial siphon structures composed of siphon valves each separated by a capillary valve to save radial space in a fluidic system. Such serial siphon valves allow to sequentially distribute liquids in a fluidic system upon application of successive centripetal accelerations and decelerations applied to a rotary platform.Type: ApplicationFiled: March 3, 2008Publication date: April 28, 2011Inventors: Michel G. Bergeron, Regis Peytavi, Horacio Kido, Marc Madou
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Publication number: 20090023610Abstract: A microfluidic flow cell for removably interfacing with a removable-member for performing a reaction therebetween. The microfluidic flow cell device comprises at least one reaction portion defining with the removable-member a reaction chamber when in an interfaced position thereof. The microfluidic flow cell comprises at least one fluid-receiving portion for receiving a fluid therein and being in fluid communication with the reaction chamber. When the microfluidic flow cell and the removable-member are in the interfaced position, the cell is adapted to allow for the fluid in the fluid-receiving portion to flow to the reaction chamber. Devices, systems and methods comprising this microfluidic flow cell are also disclosed.Type: ApplicationFiled: March 29, 2005Publication date: January 22, 2009Inventor: Regis Peytavi
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Publication number: 20080305966Abstract: Methods for selecting and designing optimal nucleic acid-based probe for improving the sensitivity of detection of a nucleic acid-based target are disclosed herein. The capture probes generated from these methods show a significant improvement in the sensitivity of detection. Improved probes as well as microarrays and kits comprising these probes are disclosed herewith.Type: ApplicationFiled: June 30, 2005Publication date: December 11, 2008Inventors: Regis Peytavi, Frederic Raymond
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Publication number: 20070178470Abstract: This present invention relates methods for detecting the presence of nucleic acids in a sample. In these methods, neutral capture probes are exposed to a sample possibly containing complementary nucleic acid targets. The foregoing mixture is submitted to conditions that provide for the nucleic acid targets to bind with the neutral probes thereby generating hybrids. These hybrids are submitted to positively charged reporters such as atoms, molecules or macromolecules, which electrostatically bind to the hybrids. The complexes formed between reporters and hybrids are detected by a variety of detection methods. Kits for detecting the presence of nucleic acids in a sample are also disclosed herein.Type: ApplicationFiled: December 13, 2004Publication date: August 2, 2007Applicant: INFECTIO RECHERCHE INC.Inventors: Luc Bissonnette, Frederic Raymond, Regis Peytavi
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Patent number: D799715Type: GrantFiled: October 23, 2015Date of Patent: October 10, 2017Assignees: Gene POC, Inc., Universite LavalInventors: Sébastien Chapdelaine, Régis Peytavi, Thomas-Éric Beliveau, François Gaucher, Patrick Mainville