Abstract: Differentially methylated positions associated with hypersomnolence, idiopathic hypersomnia, and long sleep time are provided herein along with biomarker panels thereof and methods of diagnosing and providing a prognosis of hypersomnolence, idiopathic hypersomnia, and long sleep time using said differentially methylated positions.

Abstract: A method for diagnosing or giving a prognosis for anxious temperament or trait-like anxiety in a human or non-human primate subject comprising the steps of (a) obtaining DNA from a blood or saliva sample from the subject and (b) quantifying methylation in a set of differentially methylated regions (DMRs) selected from SEQ ID NOs: 1-32, 34-44, 46-53, and 55-74, GCTCA, CGCACCG, AGAGGCAG, and AGCTCG or DMR-associated genes selected from DIP2C, GRB10, INPP5A, C17ORF97, PDXK, CACNA2D4, TRAPPC9, CRTC1, MEGF6, HIVEP3, OPCML, PITPNM2, ZFPM1, RAP1GAP2, NFATC1, RNF126, FSTL3, GNAS, SH3BP2, NEURL1B, MAD1L1, HSPA12B, IGF2, PEG10, PEG3, SLC16A3, SYTL1, and ZIM2, wherein a significant change methylation indicates the present of anxious temperament or trait-like anxiety, wherein the change is relative to DNA from a second human or non-human primate who does not have anxious temperament or trait-like anxiety.

Abstract: A method for diagnosing or giving a prognosis for anxious temperament or trait-like anxiety in a human or non-human primate subject comprising the steps of (a) obtaining DNA from a blood or saliva sample from the subject and (b) quantifying methylation in a set of differentially methylated regions (DMRs) selected from SEQ ID NOs:1-75 or DMR-associated genes selected from DIP2C, GRB10, INPP5A, C17ORF97, PDXK, CACNA2D4, TRAPPC9, CRTC1, MEGF6, HIVEP3, OPCML, PITPNM2, ZFPM1, RAP1GAP2, NFATC1, RNF126, FSTL3, GNAS, SH3BP2, NEURL1B, MAD1L1, HSPA12B, IGF2, PEG10, PEG3, SLC16A3, SYTL1, and ZIM2, wherein a significant change methylation indicates the present of anxious temperament or trait-like anxiety, wherein the change is relative to DNA from a second human or non-human primate who does not have anxious temperament or trait-like anxiety. Also disclosed is a biomarker panel of DMR and DMR-associated genes for the diagnosis or prognosis of anxious temperament or trait-like anxiety.

Abstract: Provided herein is technology for Alzheimer's disease testing and particularly, but not exclusively, methods, compositions, and related uses for detecting the presence of Alzheimer's disease.

Abstract: Provided herein is technology for Alzheimer's disease testing and particularly, but not exclusively, methods, compositions, and related uses for detecting the presence of Alzheimer's disease.

Abstract: A projector shield including a clear obelisk optic configured to modulate light exiting a vehicular headlamp. The clear obelisk optic comprises a base configured to sufficiently allow the passage of light therethrough, and a tip configured to refract light thereby preventing it from exiting the vehicular headlamp. The clear obelisk optic generates a light projection having a sufficiently dimmed area compared to surrounding areas.

Abstract: A projector shield including a clear obelisk optic configured to modulate light exiting a vehicular headlamp. The clear obelisk optic comprises a base configured to sufficiently allow the passage of light therethrough, and a tip configured to refract light thereby preventing it from exiting the vehicular headlamp. The clear obelisk optic generates a light projection having a sufficiently dimmed area compared to surrounding areas.

Abstract: Provided is an individually packaged pod for receptacles of smoking pipes and other smoking devices. The individually packaged pod may have a product, such as herbs or herb mixtures, placed inside the individually packaged pod. The individually packaged pod may include an insert, a ring, and a cover. The insert may be made of a mesh having a convex three-dimensional shape to form a receptacle for receiving the product. The ring may be connected to the insert and configured to maintain the convex three-dimensional shape of the insert. The cover may be made of a sheet material and attached to the ring to enclose the product inside the insert. Upon placing the individually packaged pod into a receptacle of a pipe, a user may ignite the cover and the product inside the individually packaged pod. Burning of the product creates smoke to be inhaled by the user.

Abstract: An adaptive driving beam headlamp includes a plurality of light-emitting diodes (LEDs) aligned in a first direction. One or more projection lenses having a toric-shape are adapted for shaping light emitted from the plurality of LEDs along the first direction. A beam shaping optic is adapted to shape light emitted from the one or more projection lenses along a second direction, different from the first direction, such that a desired beam shaping pattern is produced by the beam shaping optic in combination with the one or more projection lenses. A controller is adapted for independently controlling each of the plurality of LEDs for adaptively dimming portions of a vehicle headlamp beam of light.

Abstract: A method for diagnosing or giving a prognosis for anxious temperament or trait-like anxiety in a human or non-human primate subject comprising the steps of (a) obtaining DNA from a blood or saliva sample from the subject and (b) quantifying methylation in a set of differentially methylated regions (DMRs) selected from SEQ ID NOs:1-75 or DMR-associated genes selected from DIP2C, GRB10, INPP5A, C17ORF97, PDXK, CACNA2D4, TRAPPC9, CRTC1, MEGF6, HIVEP3, OPCML, PITPNM2, ZFPM1, RAP1GAP2, NFATC1, RNF126, FSTL3, GNAS, SH3BP2, NEURL1B, MADILL HSPA12B, IGF2, PEG10, PEGS, SLC16A3, SYTL1, and ZIM2, wherein a significant change methylation indicates the present of anxious temperament or trait-like anxiety, wherein the change is relative to DNA from a second human or non-human primate who does not have anxious temperament or trait-like anxiety. Also disclosed is a biomarker panel of DMR and DMR-associated genes for the diagnosis or prognosis of anxious temperament or trait-like anxiety.

Abstract: Provided herein is technology for Alzheimer's disease testing and particularly, but not exclusively, methods, compositions, and related uses for detecting the presence of Alzheimer's disease.

Abstract: An adaptive driving beam headlamp includes a plurality of light-emitting diodes (LEDs) aligned in a first direction. One or more projection lenses having a toric-shape are adapted for shaping light emitted from the plurality of LEDs along the first direction. A beam shaping optic is adapted to shape light emitted from the one or more projection lenses along a second direction, different from the first direction, such that a desired beam shaping pattern is produced by the beam shaping optic in combination with the one or more projection lenses. A controller is adapted for independently controlling each of the plurality of LEDs for adaptively dimming portions of a vehicle headlamp beam of light.

Abstract: A system and method for threat detection and management. The method includes: comparing the observed activity with a threat profile; generating a threat detection signal including threat information when the observed activity matches the threat profile; altering an operating characteristic of a client device in response to a threat response signal; receiving the threat information; evaluating the threat information; automatically determining an appropriate response to the threat detection signal based on an evaluation of the threat information; comparing the threat detection signal to known threat patterns; distributing new threat information if the threat detection signal does not match a known threat pattern; storing threat information; and providing a user interface information and controls for delivering control information over a control protocol.