Abstract: A one-phase microemulsion composition, which can be easily prepared without the use of special equipment, has high safety, and stays stable for a long period in an ultrafine emulsion state when the composition is added to an aqueous formulation, is provided by appropriately adjusting the ratio of (A) a hydrophilic nonionic surfactant, (B) a lipophilic nonionic surfactant, (C) an oil component, (D) a water-miscible solvent that does not interdissolve with the oil component, and the critical micelle concentration (CMC) of the hydrophilic nonionic surfactant in the water-miscible solvent is higher than that of the hydrophilic nonionic surfactant in water, and (E) water.

Abstract: A skin treatment composition that characteristically contains alkylene polyglycol dineopentanoate having a specific structure. The object is to provide a skin treatment composition that gives a refreshing sensation at the time of application and contains an oil component that is highly safe with low skin irritation. The skin treatment composition specifically contains diethyleneglycol dineopentanoate, triethyleneglycol dineopentanoate, tetraethyleneglycol dineopentanoate, dipropyleneglycol dineopentanoate, tripropyleneglycol dineopentanoate, etc. Dipropyleneglycol dineopentanoate and tripropyleneglycol dineopentanoate are particularly preferable in terms of the sensation at the time of application; they provide a skin treatment composition that is particularly superior in absorption into the skin and a sensation of permeation and highly safe.

Abstract: The present invention provides: an oil-in-water emulsion composition, into which an oil-soluble drug is stably incorporated and which is excellent in feeling during use; and a method for producing the aforementioned composition, which does not require complicated operations. An oil-in-water emulsion composition comprising; (A) a polyoxyethylene phytosterol, (B) a glycerin fatty acid diester, (C) a polyoxyethylene-polyoxypropylene random copolymer dialkyl ether, (D) an oil-soluble drug, (E) oil, and (F) water; wherein a layered gel structure composed of the components (A) and (B) is present in an emulsion particle in the emulsion composition.

Abstract: The present invention provides a simple and economical production method, without using a large amount of thickeners, of a high-viscosity O/W cream. The production method comprising: emulsifying, at 70° C. or higher, an oil phase with a water phase to prepare an O/W emulsified part, wherein the oil phase comprises (A) a nonionic surfactant, (B) a linear higher alcohol that has 16 or more carbon atoms and can form an ?-gel in water with (A), and (C) an oil component, and the water phase comprises (D) water; cooling the emulsified part while being stirred; and stopping the stirring at the peak temperature or higher in a temperature range wherein the oil phase forms an ?-gel in the water phase, but lower than 70° C. The peak temperature is the exothermic peak measured by DSC of the emulsified part. The viscosity of the O/W cream measured with a B-type viscometer at 30° C. is preferably 8,000 mPa·s or higher.

Abstract: The present invention provides a production method that can easily produce an O/W emulsion composition without using a special cooling apparatus and be economical. The production method of an O/W emulsion composition comprising: emulsifying, at 70° C. or higher, an oil phase with a portion of a water phase to prepare an emulsified part, wherein the oil phase comprises (A) a nonionic surfactant, (B) a linear higher alcohol that has 16 or more carbon atoms and can form an ?-gel in water with the nonionic surfactant, and (C) an oil component, and the water phase comprises (D) water; mixing the remaining main water phase at 10 to 35° C. with the emulsified part while being stirred, to cool the emulsified part with continuous stirring to the lower temperature limit, or lower, of a temperature range wherein the oil phase forms an ?-gel in the water phase; and then stopping the stirring.

Abstract: The present invention provides a production method of a fine O/W emulsion external preparation having the emulsion particle size of 50 to 500 nm comprising the steps of: mixing with stirring, at 70 to 80° C., (A) a hydrophilic nonionic surfactant, (B) a linear higher alcohol having 16 or more carbon atoms, (C) an oil component, (D) an aqueous solvent which can be soluble in water, wherein the critical micelle concentration (c.m.c.) of the hydrophilic nonionic surfactant in the aqueous solvent is higher than that in water, and (E) water in the amount of 5 to 25 mass % of the total amount of (A) to (E), to prepare a W/O emulsion; and adding, while mixing with stirring, (F) water or an aqueous formulation at 10 to 35° C. into the W/O emulsion to invert the W/O emulsion to a fine O/W emulsion. The production method needs not to use any cooling apparatus, has excellent economical efficiency, can easily produce a fine O/W emulsion external preparation excellent in safety and stability.

Abstract: A hair conditioning composition containing very little water from which a hair conditioner can be easily produced by diluting with water, and a low energy production method thereof. A hair conditioning composition including (a) 10 to 90% by mass of specifically structured higher alcohols and/or derivatives thereof, (b) 5 to 35% by mass of cationic surfactant, and (c) a polyhydric alcohol and/or polyethylene glycol having a melting point of 70° C. or less, wherein the melting point of a gel which is formed from (a) and (b) in the composition is 70° C. or less, the water content is 10% by mass or less, and the molar ratio of (a) to (b) is 2.5 or more to less than 6.0. Also, a low energy method of producing a hair conditioner by melting the hair conditioning composition under heating at the temperature of the melting point of gel or more to 70° C. or less, and diluting it with water in an amount of 3 to 15 times by mass.

Abstract: The present invention provides an oil-in-oil type cosmetic composition that has excellent transfer resistance after application, a luster, favorable spreadability during application, and also excellent stability. The oil-in-oil type cosmetic composition comprises (a) 5 to 80% by mass of non-volatile hydrocarbon oil, (b) 1 to 70% by mass of non-volatile silicone oil, and (c) 0.1 to 10% by mass of dextrin fatty acid ester. Preferably, the non-volatile hydrocarbon oil (a) and the non-volatile silicone oil (b) are formulated at a ratio (mass ratio) of (a)/[(a)+(b)]=0.4 to 0.8.

Abstract: The present invention provides an easily-handled hair conditioning composition with a very low water content. The hair conditioning composition of the present invention is a composition comprising: (a) 10 to 90% by mass of one or more components selected from higher alcohols, higher fatty acids, and derivatives thereof, (b) 5 to 35% by mass of a cationic surfactant, and (c) a polyhydric alcohol and/or polyethylene glycol having a melting point of 155° C. or less, characterized in that the endothermic peak of a gel which is formed from (a) and (b) in the composition is 50° C. or more as measured by a differential scanning calorimeter (DSC) and that the water content is 10% by mass or less.

Abstract: When a poorly water-soluble ultraviolet ray absorber is used, it is difficult to solubilize a sufficient amount of the poorly water-soluble ultraviolet ray absorber by using a surfactant such as a polyoxyethylene alkyl ether or a polyoxyethylene hydrogenated castor oil. Thus, an object aims to provide a water-containing composition in which a poorly water-soluble ultraviolet ray absorber is solubilized or dispersed in water. Another object aims to dissolve a poorly water-soluble ultraviolet ray absorber in water and allow the poorly water-soluble ultraviolet ray absorber to co-exist with a water-soluble component such as a water-soluble medicinal agent and a water-soluble dye in the water to thereby stabilize the water-soluble component.

Abstract: An object of the present invention is to establish means for reliably incorporating a poorly soluble UV-absorbing agent into a hair cosmetic composition, to thereby provide a hair cosmetic composition which has excellent effect of preventing UV-hair damage and which exhibits favorable sensation in use thereof. Specifically, the object can be attained through provision of a hair cosmetic composition including the following ingredients (1) and (2): (1) a polyoxy(lower alkylene) addition compound represented by formula (I): wherein R represents a phytosterol residue or a phytostanol residue; m is a number from 0 to 100; and n is a number from 5 to 100, and (2) a UV-absorbing agent having a triazine group.

Abstract: An object of the present invention is to provide means for enhancing ability to solubilize a low water-soluble substance or to disperse the substance in water. The present invention provides a water-containing composition containing water; at least one polyoxyethylene-polyoxypropylene-added phytosterol or phytostanol represented by the following formula (1): [wherein R represents a phytosterol residue or a phytostanol residue; m is a number from 5 to 100; and n is a number from 5 to 100]; and at least one low water-soluble substance which is in a dissolved state.

Abstract: The present invention provides: an oil-in-water emulsion composition, into which an oil-soluble drug is stably incorporated and which is excellent in feeling during use; and a method for producing the aforementioned composition, which does not require complicated operations. An oil-in-water emulsion composition comprising; (A) a polyoxyethylene phytosterol, (B) a glycerin fatty acid diester, (C) a polyoxyethylene-polyoxypropylene random copolymer dialkyl ether, (D) an oil-soluble drug, (E) oil, and (F) water; wherein a layered gel structure composed of the components (A) and (B) is present in an emulsion particle in the emulsion composition.

Abstract: A skin treatment composition of the present invention is an external composition for skin comprising an alkylene oxide derivative expressed by Formula (I): R1O—[(AO)m(EO)n]—R2??(I) wherein AO is an oxyalkylene group of C3 or C4; EO is an oxyethylene group; m and n are 1?m?70 and 1?n?70 respectively, wherein EO is 20˜80% by weight with respect to a total of AO and EO; each of R1 and R2 is a hydrogen or a hydrocarbon group having C1-4. The alkylene oxide derivative (I) has a moisturizing effect, a rough skin improving effect, a stickiness improving effect, and a transdermal absorption promoting effect. When a refreshing agent is used together therewith in the composition of the present invention, the refreshing effect lasts for a long time and it is excellent in feeling of use without skin stimulation.

Abstract: The present invention is to provide a skin external preparation with good moisture retention, a rough skin improving effect, and an improved feeling in use. A skin external preparation comprising a polyoxyalkylene glycol/polyethylene glycol copolymer alkyl ether derivative represented by the below-described general formula (I): (formula I) Y—{O(EO)a/(AO)b—R}k??(I) (In the formula, Y is the residue given by removing hydroxyl groups from a polyhydric alcohol having 3 to 6 hydroxyl groups, and k is the number of hydroxyl groups of the polyhydric alcohol. EO is an oxyethylene group; AO is an oxyalkylene group having 3 to 4 carbon atoms, and 1?a?70, 1?b?70. The percentage of the oxyethylene groups with respect to the sum of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is 20 to 100 mass %. The oxyalkylene group having 3 to 4 carbon atoms and the oxyethylene group are added randomly.

Abstract: A skin treatment composition that characteristically contains alkylene polyglycol dineopentanoate having a specific structure. The object is to provide a skin treatment composition that gives a refreshing sensation at the time of application and contains an oil component that is highly safe with low skin irritation. The skin treatment composition specifically contains diethyleneglycol dineopentanoate, triethyleneglycol dineopentanoate, tetraethyleneglycol dineopentanoate, dipropyleneglycol dineopentanoate, tripropyleneglycol dineopentanoate, etc. Dipropyleneglycol dineopentanoate and tripropyleneglycol dineopentanoate are particularly preferable in terms of the sensation at the time of application; they provide a skin treatment composition that is particularly superior in absorption into the skin and a sensation of permeation and highly safe.

Abstract: The present invention is a skin treatment composition that characteristically contains an alkyl benzoate represented by the following general formula (1). This provides a skin treatment composition that gives a refreshing sensation at the time of application and can contain drugs and ultraviolet absorbents in a stable manner. Also, the present invention is a sunblock water-in-oil type emulsified cosmetic characteristically comprising an ester bond product of polyhydroxystearic acid represented by the following general formulas (2) or (3), alkyl benzoate represented by the following general formula (1), and an ultraviolet absorbent. This provides a sunblock cosmetic consisting of a water-in-oil type emulsified composition that can contain an ultraviolet absorbent in a stable manner and exhibits a superior usability. (In this formula, R denotes a branched or straight chain alkyl group having 8-15 carbon atoms.

Abstract: A one-phase microemulsion composition, which can be easily prepared without the use of special equipment, has high safety, and stays stable for a long period in an ultrafine emulsion state when the composition is added to an aqueous formulation, is provided by appropriately adjusting the ratio of (A) a hydrophilic nonionic surfactant, (B) a lipophilic nonionic surfactant, (C) an oil component, (D) a water-miscible solvent that does not interdissolve with the oil component, and the critical micelle concentration (CMC) of the hydrophilic nonionic surfactant in the water-miscible solvent is higher than that of the hydrophilic nonionic surfactant in water, and (E) water.

Abstract: A process for producing an aminoalkylsulfonic acid of formula [2]: wherein R1 and R2 are each independently hydrogen, alkyl, aryl or aralkyl; and R3 and R4 are each independently hydrogen or alkyl, comprising reacting an aminoalkylsulfonate salt of formula [1]: wherein M is alkali metal, organic ammonium or ammonium ion; and R1 to R4 are as described above, an aqueous solution thereof, or a solution dissolving any one of them in a water-soluble organic solvent, selected from alcohols having 1 to 3 carbon, carboxylic acids having 2 to 12 carbon and dimethylformamide, with an organic acid; and a method of salt exchange for an aminoalkylsulfonate salt of formula [1?]: wherein M? is alkali metal, organic ammonium or ammonium ion; and R1 and R4 are as described above, comprising reacting the aminoalkylsulfonate salt formula [2] with a hydroxide of formula [6]: M?OH[6] wherein M? is as described above, in alcohol or water.

Abstract: A process for producing an aminoalkylsulfonic acid of formula [2]: wherein R1 and R2 are each independently hydrogen, alkyl, aryl or aralkyl; and R3 and R4 are each independently hydrogen or alkyl, comprising reacting an aminoalkylsulfonate salt of formula [1]: wherein M is alkali metal, organic ammonium or ammonium ion; and R1 to R4 are as described above, an aqueous solution thereof, or a solution dissolving any one of them in a water-soluble organic solvent, selected from alcohols having 1 to 3 carbon, carboxylic acids having 2 to 12 carbon and dimethylformamide, with an organic acid; and a method of salt exchange for an aminoalkylsulfonate salt of formula [1?]: wherein M? is alkali metal, organic ammonium or ammonium ion; and R1 and R4 are as described above, comprising reacting the aminoalkylsulfonate salt formula [2] with a hydroxide of formula [6]: M?OH??[6] wherein M? is as described above, in alcohol or water.