Patents by Inventor Reijo Toivola

Reijo Toivola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Toremifene crystallization method
    Patent number: 7368607
    Abstract: The invention relates to a method for isolating toremifene from a mixture of toremifene and its corresponding E isomer. The method comprises contacting the isomer mixture with a first solvent comprising methanol, allowing toremifene to crystallize in said first solvent, allowing the crystallized product of the previous step to crystallize from a second solvent comprising acetone, methyl ethyl ketone or ethyl acetate, and optionally converting toremifene crystallized from the previous step to a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 19, 2004
    Date of Patent: May 6, 2008
    Assignee: Orion Corporation
    Inventors: Reijo Toivola, Tuomas Huuhtanen
  • Toremifene crystallization method
    Publication number: 20070093556
    Abstract: The invention relates to a method for isolating toremifene from a mixture of toremifene and its corresponding E isomer. The method comprises contacting the isomer mixture with a first solvent comprising methanol, allowing toremifene to crystallize in said first solvent, allowing the crystallized product of the previous step to crystallize from a second solvent comprising acetone, methyl ethyl ketone or ethyl acetate, and optionally converting toremifene crystallized from the previous step to a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 19, 2004
    Publication date: April 26, 2007
    Inventors: Reijo Toivola, Tuomas Huuhtanen