Patents by Inventor Reiko Hirai

Reiko Hirai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for production of L-lysine using methanol-utilizing bacterium
    Patent number: 8017363
    Abstract: A method for production of L-lysine is provided which includes the steps of cultivating a methanol-utilizing bacterium in a culture medium to produce and accumulate L-lysine in the culture medium and collecting the L-lysine from the culture medium, wherein the methanol-utilizing bacterium contains DNA encoding dihydrodipicolinate synthetase which is desensitized to feedback inhibition by L-lysine and DNA encoding a LysE protein that can enhance the excretion of L-lysine out of the methanol-utilizing bacterium, and the bacterium is modified so as to increase the intracellular activities of diaminopimelic acid dehydrogenase, diaminopimelic acid decarboxylase, dihydrodipicolinic acid reductase and aspartate-semialdehyde dehydrogenase.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: September 13, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yoshiya Gunji, Hisashi Yasueda, Reiko Hirai, Seiko Hirano
  • METHOD FOR PRODUCTION OF L-LYSINE USING METHANOL-UTILIZING BACTERIUM
    Publication number: 20100190216
    Abstract: A method for production of L-lysine is provided which includes the steps of cultivating a methanol-utilizing bacterium in a culture medium to produce and accumulate L-lysine in the culture medium and collecting the L-lysine from the culture medium, wherein the methanol-utilizing bacterium contains DNA encoding dihydrodipicolinate synthetase which is desensitized to feedback inhibition by L-lysine and DNA encoding a LysE protein that can enhance the excretion of L-lysine out of the methanol-utilizing bacterium, and the bacterium is modified so as to increase the intracellular activities of diaminopimelic acid dehydrogenase, diaminopimelic acid decarboxylase, dihydrodipicolinic acid reductase and aspartate-semialdehyde dehydrogenase.
    Type: Application
    Filed: August 1, 2008
    Publication date: July 29, 2010
    Inventors: Yoshiya Gunji, Hisashi Yasueda, Reiko Hirai, Seiko Hirano