Patents by Inventor Rein Ulijn

Rein Ulijn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250179558
    Abstract: A system includes an aqueous solution containing a positively charged peptide, a molecular counterion thereto, and a molecular beacon. The molecular beacon includes a DNA construct including single-stranded DNA tending to form a hairpin (HP) configuration and having (1) a central loop region complementary to a target sequence, (2) regions at opposing ends complementary to one another, and (3) a fluorophore and a quencher thereof at the opposing ends, such that binding with the target sequence results in dissociation of the DNA regions at the opposing ends, thereby separating the fluorophore and quencher with a resulting increase in fluorescence. The system may be useful in nucleotide detection methods.
    Type: Application
    Filed: October 30, 2024
    Publication date: June 5, 2025
    Applicant: The Government of the United States of America, as represaented by the Secretary of the Navy
    Inventors: Sebastian A. Diaz, Deborah Sementa, Igor L. Medintz, Rein Ulijn, Christopher M. Green
  • Patent number: 12018661
    Abstract: A thin film that has a flexible polymer layer and a peptide layer. The peptide layer is disposed on the flexible polymer layer and has a peptide selected from HYF, DYF and YFD. The thin film reversibly curves with changes in humidity.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: June 25, 2024
    Assignee: Research Foundation of the City University of New York
    Inventors: Xi Chen, Rein Ulijn, Roxana Piotrowska
  • Publication number: 20210404450
    Abstract: A thin film that has a flexible polymer layer and a peptide layer. The peptide layer is disposed on the flexible polymer layer and has a peptide selected from HYF, DYF and YFD. The thin film reversibly curves with changes in humidity.
    Type: Application
    Filed: January 4, 2021
    Publication date: December 30, 2021
    Inventors: Xi Chen, Rein Ulijn, Roxana Piotrowska
  • Patent number: 10646538
    Abstract: The present invention relates to a method of predicting the propensity of tripeptides to from aggregates in solution. The present invention also provides tripeptides which are able to form aggregates in solution, as well as uses thereof. The present invention also provides nanostructures formed by self-aggregation of tripeptides of the present invention. The present invention also provides pH responsive aggregates as well as methods of screening for the ability of a tripeptide to form a pH dependent aggregate or gel.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: May 12, 2020
    Assignee: ENDO Biologics, Inc.
    Inventors: Rein Ulijn, Tell Tuttle, Pim Frederix, Gary Scott, Yousef Abul-Haija
  • Publication number: 20170246237
    Abstract: The present invention relates to a method of predicting the propensity of tripeptides to from aggregates in solution. The present invention also provides tripeptides which are able to form aggregates in solution, as well as uses thereof. The present invention also provides nanostructures formed by self-aggregation of tripeptides of the present invention. The present invention also provides pH responsive aggregates as well as methods of screening for the ability of a tripeptide to form a pH dependent aggregate or gel.
    Type: Application
    Filed: October 9, 2015
    Publication date: August 31, 2017
    Inventors: Rein ULIJN, Tell TUTTLE, Pim FREDERIX, Gary SCOTT, Yousef ABUL-HAIJA
  • Publication number: 20170188618
    Abstract: The present invention relates to the formation of emulsions using small amphipathic molecules, such as peptides which self-assemble to form an interface between at least two substantially immiscible liquids. The emulsions may find application is a variety of technological fields, such as in food, cosmetics, life style products, coating, catalysis, encapsulation, drug delivery and/or cell assays. There is also provided a method of making such emulsions, as well as methods of tailoring the stability of the emulsions for particular applications.
    Type: Application
    Filed: May 22, 2015
    Publication date: July 6, 2017
    Inventors: Rein ULIJN, Tell TUTTLE, Ines MOREIRA, Gary SCOTT, Paul John MCKNIGHT, Martin Edwin RUCK
  • Publication number: 20160177292
    Abstract: A method for screening catalytic peptides using phage display technology is disclosed. A compound is exposed to a phage library. If a peptide in the library catalyzes a reaction, a gel is formed about the phage that displays the peptide. The gel, including the first phage, is separated from un-reacted phages and released from the gel. The phage is then replicated and analyzed to determine the composition of the peptide that functioned as a catalyst.
    Type: Application
    Filed: July 3, 2013
    Publication date: June 23, 2016
    Applicant: Research Foundation of the City University of New York
    Inventors: Hiroshi Matsui, Yoshiaki Maeda, Rein Ulijn
  • Patent number: 8318206
    Abstract: The present invention provides a particle aggregate comprising particles linked to other particles via linkers that are capable of being cleaved by an enzyme. The particles may be linked directly to other particles by the linkers or may be linked indirectly by means of a binding moiety. The invention also provides a particle coupled to a binding moiety via a linker that can be cleaved by an enzyme. The present invention may be used in diagnosing a disease or condition associated with the enzyme, or may be used to treat such a disease or condition whereby the drug is retained in the particle aggregate until the linkers are cleaved by the enzyme.
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: November 27, 2012
    Assignee: Imperial Innovations Limited
    Inventors: Molly M. Stevens, Rein Ulijn, Anna Sague Laromaine, Liling Koh
  • Publication number: 20100143438
    Abstract: A substrate is provided having a biomolecule immobilised thereon, wherein the biomolecule is connected via an enzyme-cleavable link to a blocking moiety such that cleavage of the link causes removal of the blocking moiety and activation of the biomolecule.
    Type: Application
    Filed: November 19, 2007
    Publication date: June 10, 2010
    Applicant: University of Strathclyde
    Inventors: John Simon Todd, Vincent Rein Ulijn, Julie Gough
  • Publication number: 20090181097
    Abstract: The present invention provides a particle aggregate comprising particles linked to other particles via linkers that are capable of being cleaved by an enzyme. The particles may be linked directly to other particles by the linkers or may be linked indirectly by means of a binding moiety. The invention also provides a particle coupled to a binding moiety via a linker that can be cleaved by an enzyme. The present invention may be used in diagnosing a disease or condition associated with the enzyme, or may be used to treat such a disease or condition whereby the drug is retained in the particle aggregate until the linkers are cleaved by the enzyme.
    Type: Application
    Filed: November 29, 2006
    Publication date: July 16, 2009
    Inventors: Molly M. Stevens, Rein Ulijn, Anna Sague Laromaine, Liling Koh
  • Publication number: 20070099840
    Abstract: Hydrogel compositions comprise an aqueous dispersion phase and a plurality of peptides, or derivatives, or analogues thereof. Each peptide comprises at least two amino acid residues and an aromatic stacking ligand and the hydrogel is formed by self-assembly of said peptides in said aqueous dispersion medium. The aqueous dispersion phase is physiologically acceptable and may have a pH of 6 to 8, as may the hydrogel itself. The hydrogel may be used for cell culture or for treatment of medical conditions characterised by tissue loss/damage.
    Type: Application
    Filed: September 7, 2006
    Publication date: May 3, 2007
    Applicant: THE UNIVERSITY OF MANCHESTER
    Inventors: Rein Ulijn, Vineetha Jayawarna, Andrew Smith, Julie Gough