Patents by Inventor Reinhard DUMMER

Reinhard DUMMER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION THERAPY USING INHIBITORS OF HUMAN GROWTH AND DIFFERENTIATION FACTOR 15 (GDF-15) AND IMMUNE CHECKPOINT BLOCKERS
    Publication number: 20230093412
    Abstract: The present invention relates to uses of inhibitors of human Growth and Differentiation Factor 15 (GDF-15), and to combined uses of such inhibitors with immune checkpoint blockers, in the treatment of solid cancers.
    Type: Application
    Filed: August 30, 2022
    Publication date: March 23, 2023
    Inventors: Jörg WISCHHUSEN, Markus Haake, Reinhard Dummer, Matthias Mehling, Tina SCHÄFER, Martina Selle
  • Combination therapy using inhibitors of human growth and differentiation factor 15 (GDF-15) and immune checkpoint blockers
    Patent number: 11464856
    Abstract: The present invention relates to uses of inhibitors of human Growth and Differentiation Factor 15 (GDF-15), and to combined uses of such inhibitors with immune checkpoint blockers, in the treatment of solid cancers.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: October 11, 2022
    Assignee: JULIUS-MAXIMILIANS-UNIVERSITÄT Würzburg
    Inventors: Jörg Wischhusen, Markus Haake, Reinhard Dummer, Matthias Mehling, Tina Schäfer, Martina Selle
  • GDF-15 AS A DIAGNOSTIC MARKER TO PREDICT THE CLINICAL OUTCOME OF A TREATMENT WITH IMMUNE CHECKPOINT BLOCKERS
    Publication number: 20220242942
    Abstract: The present invention relates to methods for predicting the probability of a treatment response of a human cancer patient to an immune checkpoint blocker treatment e.g. with anti PD-1, and to methods for predicting the probability of survival of a human cancer patient following an immune checkpoint blocker treatment, and to apparatuses and kits which can be used in these methods.
    Type: Application
    Filed: January 20, 2022
    Publication date: August 4, 2022
    Inventors: Jörg WISCHHUSEN, Markus Haake, Reinhard Dummer, Matthias Mehling
  • GDF-15 as a diagnostic marker to predict the clinical outcome of a treatment with immune checkpoint blockers
    Patent number: 11262360
    Abstract: The present invention relates to methods for predicting the probability of a treatment response of a human cancer patient to an immune checkpoint blocker treatment e.g. with anti PD-1, and to methods for predicting the probability of survival of a human cancer patient following an immune checkpoint blocker treatment, and to apparatuses and kits which can be used in these methods.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: March 1, 2022
    Assignee: JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG
    Inventors: Jörg Wischhusen, Markus Haake, Reinhard Dummer, Matthias Mehling
  • Means and methods for identifying a patient having a BRAF-positive cancer as a non-responder to a BRAF inhibitor as a responder to an MAPK/ERK inhibitor
    Publication number: 20190194757
    Abstract: The present invention relates to the field of diagnostics, in particular, cancer diagnostics. More specifically, it relates to a method for identifying whether a subject suffering from a BRAF-positive cancer is a non-responder to a BRAF inhibitor, or not, and/or is a responder to an MAPK/ERK inhibitor, a method for diagnosing cancer, a method for assessing responsiveness to targeted therapy in a subject and a method for assessing cancer in a subject. Moreover, contemplated by the invention are a kit and a device for diagnosing cancer. Further, the invention relates to a MAPK/ERK inhibitor for use in treating a subject suffering from a BRAF-positive cancer.
    Type: Application
    Filed: July 13, 2015
    Publication date: June 27, 2019
    Inventors: Mitchell Paul Levesque, Reinhard Dummer, Daniel Widmer, Marieke Ineke Geertje Raaijmakers
  • COMBINATION THERAPY USING INHIBITORS OF HUMAN GROWTH AND DIFFERENTIATION FACTOR 15 (GDF-15) AND IMMUNE CHECKPOINT BLOCKERS
    Publication number: 20190160169
    Abstract: The present invention relates to uses of inhibitors of human Growth and Differentiation Factor 15 (GDF-15), and to combined uses of such inhibitors with immune checkpoint blockers, in the treatment of solid cancers.
    Type: Application
    Filed: September 30, 2016
    Publication date: May 30, 2019
    Inventors: Jörg WISCHHUSEN, Markus HAAKE, Reinhard DUMMER, Matthias MEHLING, Tina SCHÄFER, Martina SELLE
  • GDF-15 AS A DIAGNOSTIC MARKER TO PREDICT THE CLINICAL OUTCOME OF A TREATMENT WITH IMMUNE CHECKPOINT BLOCKERS
    Publication number: 20180292412
    Abstract: The present invention relates to methods for predicting the probability of a treatment response of a human cancer patient to an immune checkpoint blocker treatment e.g. with anti PD-1, and to methods for predicting the probability of survival of a human cancer patient following an immune checkpoint blocker treatment, and to apparatuses and kits which can be used in these methods.
    Type: Application
    Filed: September 30, 2016
    Publication date: October 11, 2018
    Inventors: Jörg WISCHHUSEN, Markus HAAKE, Reinhard DUMMER, Matthias MEHLING