Abstract: A microprobe for electrophysiological application, a microtube, fiber or wire probe is supported on a fixture within a tubular elastic support hose end has one end together with one end of the probe mounted on a clamping structure which is movably disposed on the fixture while the other end of the probe extends through a capillary guide tube from which its tip projects and the other end of the hose is mounted on the fixture and the hose maintained in a stretched state to engage the probe and provide radial support and a microdrive is connected to the clamping structure for axially moving the probe together with the one end of the hose and an apparatus including a plurality of independently movable probes.