Patents by Inventor Reinhard Franze

Reinhard Franze has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing polypeptides with appropriate glycosilation
    Patent number: 6673575
    Abstract: The invention concerns a process for the production of a polypeptide with suitable glycosylation by culturing eukaryotic cells and isolating the polypeptide from the culture medium or/and the cells. In this process the desired glycosylated polypeptide can be produced recombinantly with the aid of endogenous gene activation or be produced naturally by the cells.
    Type: Grant
    Filed: September 5, 2000
    Date of Patent: January 6, 2004
    Assignee: Roche Diagnostics GmbH
    Inventors: Reinhard Franze, Horst Eberhardt, Claus Wallerius
  • Methods for identifying human cell lines useful for endogenous gene activation isolated human cell lines identified thereby, and uses thereof
    Patent number: 6555373
    Abstract: The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the invention concerns a process for the production of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO gene in human cells as well as a process for the large-scale production of EPO in human cells.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: April 29, 2003
    Assignee: Roche Diagnostics GmbH
    Inventors: Anne Stern, Michael Brandt, Konrad Honold, Johannes Auer, Hans Koll, Reinhard Franze, Ulrich Pessara
  • Methods for identifying human cell lines useful for endogenous gene activation, isolated human lines identified thereby, and uses thereof
    Patent number: 6548296
    Abstract: The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the invention concerns a process for the production of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO gene in human cells as well as a process for the large-scale production of EPO in human cells.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: April 15, 2003
    Assignee: Roche Diagnostics GmbH
    Inventors: Anne Stern, Michael Brandt, Konrad Honold, Johannes Auer, Hans Koll, Reinhard Franze, Ulrich Pessara
  • Identification of human cell lines for the production of human proteins by endogenous gene activation
    Publication number: 20020164792
    Abstract: A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form suitable for producing a pharmaceutical composition. Also disclosed is a process for producing human proteins in a cell line identified in this matter.
    Type: Application
    Filed: April 2, 2002
    Publication date: November 7, 2002
    Inventors: Michael Brandt, Reinhard Franze, Ulrich Pessara
  • Erythropoietin conjugates
    Publication number: 20020115833
    Abstract: The present invention refers to conjugates of erythropoietin with poly(ethylene glycol) comprising an erythropoietin glycoprotein having an N-terminal &agr;-amino group and having the in vivo biological activity of causing bone marrow cells to increase production of reticulocytes and red blood cells and selected from the group consisting of human erythropoietin and analogs thereof which have the sequence of human erythropoietin modified by the addition of from 1 to 6 glycosylation sites or a rearrangement of at least one glycosylation site; said glycoprotein being covalently linked to one poly(ethylene glycol) group of the formula
    Type: Application
    Filed: December 11, 2001
    Publication date: August 22, 2002
    Inventors: Josef Burg, Alfred Engel, Reinhard Franze, Bernd Hilger, Hartmut Ernst Schurig, Wilhelm Tischer, Manfred Wozny
  • Identification of human cell lines for the production of human proteins by endogenous gene activation
    Patent number: 6395484
    Abstract: A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form suitable for producing a pharmaceutical composition. Also disclosed is a process for producing human proteins in a cell line identified in this matter.
    Type: Grant
    Filed: May 30, 2000
    Date of Patent: May 28, 2002
    Assignee: Roche Diagnostics GmbH
    Inventors: Michael Brandt, Reinhard Franze, Ulrich Pessara