Patents by Inventor Reinhard Kotulla

Reinhard Kotulla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8131474
    Abstract: The invention relates to a method for investigating the glucose metabolism of a human being for disease-relevant and/or disease-related particularities. The glucose concentration g(t1) to g(tn) of a body fluid is measured at time points t1 to tn that are distributed over a period of at least six hours. The data points are then determined in phase space coordinates from the glucose concentration measuring values g(t1) to g(tn). The data points are then processed to highlight disease-relevant and/or disease-related particularities of the glucose metabolism of the investigated human being. The processing of the data points can be implemented by plotting them in a phase space representation or by determining from the data points a disturbance parameter that is correlated to the severity of a disturbance of glucose metabolism.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: March 6, 2012
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Arnulf Staib, Johannes Pill, Reinhard Kotulla, Reiner Hegger
  • Patent number: 7389133
    Abstract: The disclosure generally relates to continuous monitoring of an analyte by determining its change over time in the living body of a human or animal. A measurement variable value correlating with the desired concentration of the analyte are measured as the measurement signal (zt) and the change over time of the concentration is determined from the measurement signal as the useful signal (yt) using a calibration. A filter algorithm is used to reduce errors of the useful signal, which result from noise contained in the measurement signal. The filter algorithm includes an operation in which the influence of an actual measurement value on the useful signal is weighted using a weighting factor (V).
    Type: Grant
    Filed: October 11, 2007
    Date of Patent: June 17, 2008
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Reinhard Kotulla, Arnulf Staib, Ralph Gillen
  • Publication number: 20080139902
    Abstract: The disclosure generally relates to continuous monitoring of an analyte by determining its change over time in the living body of a human or animal. A measurement, variable value correlating with the desired concentration of the analyte are measured as the measurement signal (zt) and the change over time of the concentration is determined from the measurement signal as the useful signal (yt) using a calibration. A filter algorithm is used to reduce errors of thee useful signal, which result from noise contained in the measurement signal. The filter algorithm includes an operation in which the influence of an actual measurement value on the useful signal is weighted using a weighting factor (V).
    Type: Application
    Filed: October 11, 2007
    Publication date: June 12, 2008
    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Reinhard Kotulla, Arnulf Staib, Ralph Gillen
  • Publication number: 20060253067
    Abstract: The invention relates to a method for investigating the glucose metabolism of a human being for disease-relevant and/or disease-related particularities. The the glucose concentration g(t1) to g(tn) of a body fluid is measured at time points t1 to tn that are distributed over a period of at least six hours. The data points are then determined in phase space coordinates from the glucose concentration measuring values g(t1) to g(tn). The data points are then processed to highlight disease-relevant and/or disease-related particularities of the glucose metabolism of the investigated human being. The processing of the data points can be implemented by plotting them in a phase space representation or by determining from the data points a disturbance parameter that is correlated to the severity of a disturbance of glucose metabolism.
    Type: Application
    Filed: March 15, 2006
    Publication date: November 9, 2006
    Inventors: Arnulf Staib, Johannes Pill, Reinhard Kotulla, Reiner Hegger
  • Publication number: 20060052679
    Abstract: The present invention generally relates to a method for continuous monitoring of the concentration of an analyte by determining its change over time in the living body of a human or animal. A measurement variable value correlating with the desired concentration of the analyte are measured as the measurement signal (zt) and the change over time of the concentration is determined from the measurement signal as the useful signal (yt) using a calibration. A filter algorithm is used to reduce errors of the useful signal, which result from noise contained in the measurement signal. The filter algorithm includes an operation in which the influence of an actual measurement value on the useful signal is weighted using a weighting factor (V).
    Type: Application
    Filed: November 3, 2005
    Publication date: March 9, 2006
    Inventors: Reinhard Kotulla, Arnulf Staib, Ralph Gillen
  • Publication number: 20050272985
    Abstract: The present invention generally relates to a method for continuous monitoring of the concentration of an analyte by determining its change over time in the living body of a human or animal. A measurement variable value correlating with the desired concentration of the analyte are measured as the measurement signal (zt) and the change over time of the concentration is determined from the measurement signal as the useful signal (yt) using a calibration. A filter algorithm is used to reduce errors of the useful signal, which result from noise contained in the measurement signal. The filter algorithm includes an operation in which the influence of an actual measurement value on the useful signal is weighted using a weighting factor (V).
    Type: Application
    Filed: September 21, 2004
    Publication date: December 8, 2005
    Inventors: Reinhard Kotulla, Arnulf Staib
  • Patent number: 5507288
    Abstract: Analytical system for monitoring patient blood concentration of a substance to be analyzed, comprising analysis-elements (12) containing reagents and an evaluation instrument comprising a measurement device to measure a change resulting from a reaction of the analyte with the reagents in order to determine, from the measurement values so obtained, analytical data representing element analysis data C.sub.A.In order to allow continuous monitoring of the analyte with good accuracy and a reduced number of invasive sample generation steps it is proposed that the analytical system further comprises (i) a sensor unit (2) portable on the patient body, said sensor unit (2) including a sensor (7) borne on the patient body for the direct and reagent-free measurement of a parameter correlating with the concentration of the analyzed substance and a transmitter for the wireless transmission of data signals; and (ii) a sensor-analysis means to ascertain sensor-analysis data C.sub.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: April 16, 1996
    Assignee: Boehringer Mannheim GmbH
    Inventors: Dirk Bocker, Hans-Peter Haar, Peter Blasberg, Reinhard Kotulla