Patents by Inventor Reinhard Luhrmann

Reinhard Luhrmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INDUCIBLE SMALL RNA EXPRESSION CONSTRUCTS FOR TARGETED GENE SILENCING
    Publication number: 20120255045
    Abstract: The invention relates to vectors for the inducible expression of RNA molecules in eukaryotic, particularly mam
    Type: Application
    Filed: April 3, 2012
    Publication date: October 4, 2012
    Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Thomas Tuschl, Tilmann Achsel, Reinhard Lührmann, Jutta Meyer
  • RNA-INTERFERENCE BY SINGLE-STRANDED RNA MOLECULES
    Publication number: 20120246747
    Abstract: The present invention relates to sequence and structural features of single-stranded (ss)RNA molecules required to mediate target-specific nucleic acid modifications by RNA-interference (RNAi), such as target mRNA degradation and/or DNA methylation.
    Type: Application
    Filed: December 19, 2011
    Publication date: September 27, 2012
    Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Thomas TUSCHL, Javier Martinez, Agnieszka Patkaniowska, Henning Urlaub, Reinhard Lührmann
  • Inducible small RNA expression constructs for targeted gene silencing
    Patent number: 8198077
    Abstract: The invention relates to vectors for the inducible expression of RNA molecules in eukaryotic, particularly mammalian cells and transgenic animals.
    Type: Grant
    Filed: January 15, 2004
    Date of Patent: June 12, 2012
    Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Thomas Tuschl, Tilmann Achsel, Reinhard Lührmann, Jutta Meyer
  • Inducible small rna expression constructs for targeted gene silencing
    Publication number: 20060212950
    Abstract: The invention relates to vectors for the inducible expression of RNA molecules in eukaryotic, particularly mammalian cells and transgenic animals.
    Type: Application
    Filed: January 15, 2004
    Publication date: September 21, 2006
    Applicant: Max-Planck-Gesellschaft Zur Forderung Der Wisseneschaften E.V.
    Inventors: Thomas Tuschl, Tilmann Achsel, Reinhard Luhrmann, Jutta Meyer
  • Rna-interference by single-stranded rna molecules
    Publication number: 20060166910
    Abstract: The present invention relates to sequence and structural features of single-stranded (ss) RNA molecules required to mediate target-specific nucleic acid modifications by RNA-interference (RNAi), such as target mRNA degradation and/or DNA methylation.
    Type: Application
    Filed: July 10, 2003
    Publication date: July 27, 2006
    Applicant: Max-Planck-Gesellschaft zur Foerderung Der Wissenschaften E.V.
    Inventors: Thomas Tuschl, Javier Martinez, Henning Urlaub, Reinhard Luhrmann
  • Rna interference mediating small rna molecules
    Publication number: 20040259247
    Abstract: Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 19-23 nt short RNA fragments are the sequence-specific mediators of RNAi. The short interfering RNAs (siRNAs) are generated by an RNase III-like processing reaction from long dsRNA. Chemically synthesized siRNA duplexes with overhanging 3′ ends mediate efficient target RNA cleavage in the lysate, and the cleavage site is located near the center of the region spanned by the guiding siRNA. Furthermore, we provide evidence that the direction of dsRNA processing determines whether sense or antisense target RNA can be cleaved by the produced siRNP complex.
    Type: Application
    Filed: July 26, 2004
    Publication date: December 23, 2004
    Inventors: Thomas Tuschl, Sayda Mahgoub Elbashir, Winfried Lendeckel, Matthias Wilm, Reinhard Luhrmann
  • Test system for detecting a splicing reaction and use thereof
    Patent number: 6579681
    Abstract: The present invention relates to a test system comprising (a) one or more identical or different immobilized nucleic acid(s) having at least one spliceable nucleic acid, (b) at least one gel-free detection system for detecting a splicing reaction, where appropriate (c) at least one composition comprising splicing components, and preferably (d) suitable detection probes, and, where appropriate, (e) further aids.
    Type: Grant
    Filed: November 27, 2001
    Date of Patent: June 17, 2003
    Assignee: Aventis Research and Technologies GmbH & Co. KG
    Inventors: Christoph Hüls, Bettina Bauer, Claus Simandi, Reinhard Lührmann, Tilmann Achsel, Hans-Peter Vornlocher