Patents by Inventor Reinhard Schinzel

Reinhard Schinzel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SOLID PHARMACEUTICAL COMPOSITIONS COMPRISING BIOPTERIN DERIVATIVES AND USES OF SUCH COMPOSITIONS
    Publication number: 20230355630
    Abstract: Disclosed is a method of preparing a solution adapted for administration by infusion, comprising a) a compound having the formula (I): and/or a compound having the formula (II): and b) two different sodium phosphate salts, wherein the two different sodium phosphate salts are NaH2PO4·2H2O and Na2HPO4·2H2O, and wherein the quantity of the NaH2PO4·2H2O and Na2HPO4·2H2O present in the composition is chosen such that the molar ratio of both NaH2PO4·H2O and Na2HPO4·2H2O to compound (I) or compound (II) ranges from 0.02 to 0.5 and optionally NaCl. Also disclosed is a method of treating a disease in a subject, comprising the step of administering to a subject in need thereof a reconstituted solution as disclosed.
    Type: Application
    Filed: July 20, 2023
    Publication date: November 9, 2023
    Applicant: VASOPHARM GMBH
    Inventors: Peter SCHEURER, Frank TEGTMEIER, Reinhard SCHINZEL
  • Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
    Patent number: 11717522
    Abstract: The present invention relates to a method for preparing a lyophilized solid pharmaceutical composition comprising a) a compound having the formula (I): and/or a compound having the formula (II): ?and b) two different sodium phosphate salts, wherein the two different sodium phosphate salts are NaH2PO4·2H2O and Na2HPO4·2H2O, and wherein the quantity of the NaH2PO4·2H2O and Na2HPO4·2H2O present in the composition is chosen such that the molar ratio of both NaH2PO4·2H2O and Na2HPO4·2H2O to compound (I) or compound (II) ranges from 0.02 to 0.5.
    Type: Grant
    Filed: January 20, 2021
    Date of Patent: August 8, 2023
    Assignee: VASOPHARM GMBH
    Inventors: Peter Scheurer, Frank Tegtmeier, Reinhard Schinzel
  • SOLID PHARMACEUTICAL COMPOSITIONS COMPRISING BIOPTERIN DERIVATIVES AND USES OF SUCH COMPOSITIONS
    Publication number: 20220031703
    Abstract: The present invention relates to a method for preparing a lyophilized solid pharmaceutical composition comprising a) a compound having the formula (I): and/or a compound having the formula (II): and b) two different sodium phosphate salts, wherein the two different sodium phosphate salts are NaH2PO4.2H2O and Na2HPO4.2H2O, and wherein the quantity of the NaH2PO4.2H2O and Na2HPO4.2H2O present in the composition is chosen such that the molar ratio of both NaH2PO4.2H2O and Na2HPO4.2H2O to compound (I) or compound (II) ranges from 0.02 to 0.5.
    Type: Application
    Filed: January 20, 2021
    Publication date: February 3, 2022
    Applicant: VASOPHARM GMBH
    Inventors: Peter SCHEURER, Frank TEGTMEIER, Reinhard SCHINZEL
  • SOLID PHARMACEUTICAL COMPOSITIONS COMPRISING BIOPTERIN DERIVATIVES AND USES OF SUCH COMPOSITIONS
    Publication number: 20210137927
    Abstract: The present invention relates to a method for preparing a lyophilized solid pharmaceutical composition comprising a) a compound having the formula (I): and/or a compound having the formula (II): and b) two different sodium phosphate salts, wherein the two different sodium phosphate salts are NaH2PO4.2H2O and Na2HPO4.2H2O, and wherein the quantity of the NaH2PO4.2H2O and Na2HPO4.2H2O present in the composition is chosen such that the molar ratio of both NaH2PO4.2H2O and Na2HPO4.2H2O to compound (I) or compound (II) ranges from 0.02 to 0.5.
    Type: Application
    Filed: January 20, 2021
    Publication date: May 13, 2021
    Applicant: VASOPHARM GMBH
    Inventors: Peter SCHEURER, Frank TEGTMEIER, Reinhard SCHINZEL
  • Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
    Patent number: 10925877
    Abstract: Compositions comprising derivatives of biopterin, useful for the treatment of traumatic brain injury, non-traumatic brain injury, elevated cranial pressure, and secondary brain injury.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: February 23, 2021
    Assignee: VASOPHARM GMBH
    Inventors: Peter Scheurer, Frank Tegtmeier, Reinhard Schinzel
  • SOLID PHARMACEUTICAL COMPOSITIONS COMPRISING BIOPTERIN DERIVATIVES AND USES OF SUCH COMPOSITIONS
    Publication number: 20200046710
    Abstract: The present invention relates to a method of a method of treating a disease in a subject.
    Type: Application
    Filed: October 21, 2019
    Publication date: February 13, 2020
    Applicant: VASOPHARM GMBH
    Inventors: Peter SCHEURER, Frank TEGTMEIER, Reinhard SCHINZEL
  • Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
    Patent number: 10493075
    Abstract: The present invention relates to a method of preparing 4-Amino-(6R,S)-5,6,7,8-tetrahydro-L-biopterin dihydrochloride dihydrate.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: December 3, 2019
    Assignee: VASOPHARM GMBH
    Inventors: Peter Scheurer, Frank Tegtmeier, Reinhard Schinzel
  • SOLID PHARMACEUTICAL COMPOSITIONS COMPRISING BIOPTERIN DERIVATIVES AND USES OF SUCH COMPOSITIONS
    Publication number: 20180289714
    Abstract: The present invention relates to a method of preparing 4-Amino-(6R,S)-5,6,7,8-tetrahydro-L-biopterin dihydrochloride dihydrate.
    Type: Application
    Filed: June 8, 2018
    Publication date: October 11, 2018
    Applicant: VASOPHARM GMBH
    Inventors: Peter SCHEURER, Frank TEGTMEIER, Reinhard SCHINZEL
  • Solid pharmaceutical compositions comprising biopterin derivatives and uses of suchcompositions
    Patent number: 10016431
    Abstract: The present invention relates to a method of treating a disease in a subject, comprising administering to a subject in need thereof a solid pharmaceutical composition biopterin derivatives.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: July 10, 2018
    Assignee: VASOPHARM GMBH
    Inventors: Peter Scheurer, Frank Tegtmeier, Reinhard Schinzel
  • Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
    Patent number: 9895372
    Abstract: The present invention relates to solid pharmaceutical compositions comprising biopterin derivatives as well as methods for obtaining such solid pharmaceutical compositions. The invention also relates to the solid pharmaceutical compositions of the invention for treating diseases.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: February 20, 2018
    Assignee: VASOPHARM GMBH
    Inventors: Peter Scheurer, Frank Tegtmeier, Reinhard Schinzel
  • SOLID PHARMACEUTICAL COMPOSITIONS COMPRISING BIOPTERIN DERIVATIVES AND USES OF SUCH COMPOSITIONS
    Publication number: 20170296543
    Abstract: The present invention relates to a method of treating a disease in a subject, comprising administering to a subject in need thereof a solid pharmaceutical composition biopterin derivatives.
    Type: Application
    Filed: May 2, 2017
    Publication date: October 19, 2017
    Inventors: Peter SCHEURER, Frank TEGTMEIER, Reinhard SCHINZEL
  • SOLID PHARMACEUTICAL COMPOSITIONS COMPRISING BIOPTERIN DERIVATIVES AND USES OF SUCH COMPOSITIONS
    Publication number: 20170112836
    Abstract: The present invention relates to solid pharmaceutical compositions comprising biopterin derivatives as well as methods for obtaining such solid pharmaceutical compositions. The invention also relates to the solid pharmaceutical compositions of the invention for treating diseases.
    Type: Application
    Filed: March 30, 2015
    Publication date: April 27, 2017
    Inventors: Peter SCHEURER, Frank TEGTMEIER, Reinhard SCHINZEL
  • Substituted 1,2,3-triazolopyrimidines for the inhibition of NAD(P)H oxidases and platelet activation
    Patent number: 8236809
    Abstract: The invention relates to compounds of formula het-X-AB containing a N-heteroaryl moiety “het”, which is linked via X=sulfur to the 1,2,3-triazolo[4,5-d]pyrimidine-7-yl moiety AB of the formula (II). The invention also relates to a process for the preparation of said compounds and the use thereof in drugs for the treatment of NAD(P)H oxidase-related diseases and disorders and inhibition of platelet activation.
    Type: Grant
    Filed: May 13, 2005
    Date of Patent: August 7, 2012
    Assignee: Vasopharm GmbH
    Inventors: Frank Tegtmeier, Ulrich Walter, Reinhard Schinzel, Kirstin Wingler, Peter Scheurer, Harald Schmidt
  • Compounds Containing a N-Heteroaryl Moiety Linked to Fused Ring Moieties for the Inhibition of Nad(P)H Oxidases and Platelet Activation
    Publication number: 20080044354
    Abstract: The invention relates to compounds containing a N-heteroaryl moiety, which is linked via oxygen, sulfur or nitrogen, or via a methylene bridge and oxygen, sulfur or nitrogen to a fused ring moiety, in particular to the 1,2,3-triazolo[4,5d]pyrimidine-7-yl radical. The invention also relates to a process for the preparation of said compounds and the use thereof in drugs for the treatment of NAD(P)H oxidases-related diseases and disorders and inhibition of platelet activation.
    Type: Application
    Filed: May 13, 2005
    Publication date: February 21, 2008
    Inventors: Frank Tegtmeier, Ulrich Walter, Reinhard Schinzel, Kirstin Wingler, Peter Scheurer, Harald Schmidt