Abstract: The present invention relates to a floor drain for draining water from a walk-in floor into a waste water pipe, with an inlet channel socket, a first receiving body for the inlet channel socket, a second receiving body for the first receiving body and a drain housing following the second receiving body in the water drainage direction, which is preferably designed as an odor trap, wherein the first receiving body has a bowl-shaped section, to the outer edge of which a flexible sealing mat is connected in a liquid-tight manner and the bottom of which passes into a first drain connection piece which can be inserted into the second receiving body, wherein the second receiving body has a bowl-shaped section on which an outwardly projecting flange is integrally formed or attached, and wherein the bowl-shaped section of the second receiving body passes into a second drain connection piece.

Abstract: The present invention relates to a floor drain for draining water from a walk-in floor into a waste water pipe, with an inlet channel socket, a first receiving body for the inlet channel socket, a second receiving body for the first receiving body and a drain housing following the second receiving body in the water drainage direction, which is preferably designed as an odor trap, wherein the first receiving body has a bowl-shaped section, to the outer edge of which a flexible sealing mat is connected in a liquid-tight manner and the bottom of which passes into a first drain connection piece which can be inserted into the second receiving body, wherein the second receiving body has a bowl-shaped section on which an outwardly projecting flange is integrally formed or attached, and wherein the bowl-shaped section of the second receiving body passes into a second drain connection piece.

Abstract: The invention relates to a drain (1?), in particular for floor level showers, the drain comprising a pot shaped drain housing (1.1) including a shell or pot shaped base component (1.2) without a pipe connection, a laterally disposed pipe connection (1.5) and an inlet opening (1.3) at a top side of the base component, and an immersion pipe (2) which is insertable into the drain housing through the inlet opening (1.3) and defines a stench trap with the drain housing. In order to be able to adapt such a drain to various installation conditions in a flexible manner, so that the installation height, water lock height and drain output of the drain is variable, the invention provides a solution wherein the base component (1.2) is connected in an elevation-adjustable and liquid-tight manner with the drain housing (1.1).

Abstract: Systems and methods for enhancing the selective targeting of agents for preferential action at a target with reduced action with healthy tissue distal the target tissue. One or more agents can be combined with nano scale structures/particles for delivery to the target tissue. Appropriate bombardment with accelerated particle radiation, such as proton radiation, induces the release of the agents at the target site. Nano carriers can be combined with therapeutic and/or imaging enhancement agents. Imaging of the target tissue can provide a verification of the delivered dose of particle radiation. Nanocarriers can be provided with an outer shell selected for biocompatibility and durability in the in vivo environment and further selected to provide a feedback mechanism in the treatment environment to accelerate the release of the agent and reduce a total radiation dose needed for that release.

Abstract: Systems and methods for enhancing the selective targeting of agents for preferential action at a target with reduced action with healthy tissue distal the target tissue. One or more agents can be combined with nano scale structures/particles for delivery to the target tissue. Appropriate bombardment with accelerated particle radiation, such as proton radiation, induces the release of the agents at the target site. Nano carriers can be combined with therapeutic and/or imaging enhancement agents. Imaging of the target tissue can provide a verification of the delivered dose of particle radiation. Nanocarriers can be provided with an outer shell selected for biocompatibility and durability in the in vivo environment and further selected to provide a feedback mechanism in the treatment environment to accelerate the release of the agent and reduce a total radiation dose needed for that release.

Abstract: Systems and methods for enhancing the selective targeting of agents for preferential action at a target with reduced action with healthy tissue distal the target tissue. One or more agents can be combined with nano scale structures/particles for delivery to the target tissue. Appropriate bombardment with accelerated particle radiation, such as proton radiation, induces the release of the agents at the target site. Nano carriers can be combined with therapeutic and/or imaging enhancement agents. Imaging of the target tissue can provide a verification of the delivered dose of particle radiation. Nanocarriers can be provided with an outer shell selected for biocompatibility and durability in the in vivo environment and further selected to provide a feedback mechanism in the treatment environment to accelerate the release of the agent and reduce a total radiation dose needed for that release.

Abstract: The invention relates to a drain (1?), in particular for floor level showers, the drain comprising a pot shaped drain housing (1.1) including a shell or pot shaped base component (1.2) without a pipe connection, a laterally disposed pipe connection (1.5) and an inlet opening (1.3) at a top side of the base component, and an immersion pipe (2) which is insertable into the drain housing through the inlet opening (1.3) and defines a stench trap with the drain housing. In order to be able to adapt such a drain to various installation conditions in a flexible manner, so that the installation height, water lock height and drain output of the drain is variable, the invention provides a solution wherein the base component (1.2) is connected in an elevation-adjustable and liquid-tight manner with the drain housing (1.1).

Abstract: Gold nanoparticles, which have a very high physical density, are bound to a specific antibody for cancer cells and then delivered to areas in which the tumors are believed to be present. The antigens of the cancer cells attract the antibodies bound to the gold nanoparticles so that the gold nanoparticles are bound to the cancer cells. With the increase of density caused by the gold nanoparticles, contrast between the cancer cells and the surrounding tissue is increased. Thus, the accuracy of detecting and characterizing tumors in a proton computed tomography system may be increased through the use of gold nanoparticles. Additionally, because the energy loss per path length of the protons after passing through the nanoparticles is larger than the energy loss per path length prior to reaching the nanoparticles, the nanoparticles may enhance the accuracy and increase radiation doses of current proton therapy systems.

Abstract: A nanodosimeter device (15) for detecting positive ions induced in a sensitive gas volume by a radiation field of primary particle, comprising an ionization chamber (10) for holding the sensitive gas volume to be irradiated by the radiation field of primary particles; an ion counter system connected to the ionization chamber (10) for detecting the positive ions which pass through the aperture opening and arrive at the ion counter (12) at an arrival time; a particle tracking system for position-sensitive detection of the primary particles passing through the sensitive gas volume; and a data acquisition system capable of coordinating the readout of all data signals and of performing data analysis correlating the arrival time of the positive ions detected by the ion counter system relative to the position sensitive data of primary particles detected by the particle tracking system.

Abstract: A patient motion monitoring system (102) for use in a proton therapy center (100) is disclosed. The patient monitoring system (102) includes a plurality of position detector assemblies (162) with each position detector assembly (162) being constructed of a flexibly rigid support arm (132) attached to a position sensor (130). Each support arm (132) of the plurality of position detector assemblies (162) is detachably mounted to a supporting structure so as to allow the corresponding position sensor (130) to be positioned adjacent a patient (104) who is receiving proton therapy. Furthermore, each position sensor (130) of the plurality of position detector assemblies (162) generates a position signal that is indicative of the distance between a front surface of the position sensor, and an adjacent surface of the patient.