Patents by Inventor Reinhard Vehring

Reinhard Vehring has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND SYSTEMS FOR CONDITIONING OF PARTICULATE CRYSTALLINE MATERIALS
    Publication number: 20140275517
    Abstract: Methods and systems for the preparation of conditioned micronized active agents. Additionally, methods and systems for in-process conditioning of micronized active agent particles and compositions comprising conditioned micronized materials.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: Pearl Therapeutics, Inc.
    Inventors: Ali Kazmi, David Lechuga, Herm Snyder, James Ivey, Reinhard Vehring, Jason H. Speck, Sarvajna Dwivedi
  • Compositions, methods and systems for respiratory delivery of two or more active agents
    Patent number: 8815258
    Abstract: Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: August 26, 2014
    Assignee: Pearl Therapeutics, Inc.
    Inventors: Reinhard Vehring, Michael Steven Hartman, David Lechuga-Ballesteros, Adrian Edward Smith, Vidya B. Joshi, Sarvajna Kumar Dwivedi
  • Compositions for pulmonary delivery of long-acting ?adrenergic receptor agonists and associated methods and systems
    Patent number: 8808713
    Abstract: Compositions, methods and systems are provided for pulmonary delivery of long-acting muscarinic antagonists and long-acting ?2 adrenergic receptor agonists via a metered dose inhaler. In particular embodiments, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: August 19, 2014
    Assignee: Pearl Thereapeutics, Inc.
    Inventors: Reinhard Vehring, Michael Steven Hartman, Adrian Edward Smith, Vidya B. Joshi, Sarvajna Kumar Dwivedi
  • Compositions, methods and propellant-based systems for respiratory delivery of glycopyrrolate and one or more active agents
    Patent number: 8703806
    Abstract: Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: April 22, 2014
    Assignee: Pearl Therapeutics, Inc.
    Inventors: Reinhard Vehring, Michael Steven Hartman, David Lechuga-Ballesteros, Adrian Edward Smith, Vidya B. Joshi, Sarvajna Jumar Dwivedi
  • Pharmaceutical formulation comprising a water-insoluble active agent
    Patent number: 8668934
    Abstract: A method of preparing a pharmaceutical formulation comprises providing a solution comprising a first solvent, a second solvent, an active agent, and an excipient. The second solvent is less polar than the first solvent and the excipient is more soluble in water than the active agent. The first and second solvents are removed from the solution to produce particles comprising the active agent and the excipient. In one version, the excipient comprises an amino acid and/or a phospholipid. A pharmaceutical formulation made by a version of the invention comprises particles comprising an active agent and an excipient which at least partially encapsulates the active agent, wherein the excipient is more soluble in water than the active agent.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: March 11, 2014
    Assignee: Novartis AG
    Inventors: Reinhard Vehring, Danforth P Miller, David Lechuga-Ballesteros
  • Preservation of bioactive materials by freeze dried foam
    Patent number: 8617576
    Abstract: This invention provides methods, systems and compositions to preserve bioactive materials in a dried foam matrix. Methods provide non-boiling foam generation and penetration of preservative agents at temperatures near the phase transition temperature of the membranes. Bioactive materials can be preserved with high initial viability in a freeze-foam process employing low temperature secondary drying.
    Type: Grant
    Filed: May 6, 2008
    Date of Patent: December 31, 2013
    Assignee: MedImmune, LLC
    Inventors: Reinhard Vehring, Yi Ao
  • Compositions, methods and systems for respiratory delivery of two or more active agents
    Patent number: 8324266
    Abstract: Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: December 4, 2012
    Assignee: Pearl Therapeutics, Inc.
    Inventors: Reinhard Vehring, Michael Steven Hartman, David Lechuga-Ballesteros, Adrian Edward Smith, Vidya B. Joshi, Sarvajna Kumar Dwivedi
  • COMPOSITIONS, METHODS & SYSTEMS FOR RESPIRATORY DELIVERY OF TWO OR MORE ACTIVE AGENTS
    Publication number: 20120039952
    Abstract: Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
    Type: Application
    Filed: May 17, 2011
    Publication date: February 16, 2012
    Applicant: PEARL THERAPEUTICS, INC.
    Inventors: Reinhard Vehring, Michael Steven Hartman, David Lechuga-Ballesteros, Adrian Edward Smith, Vidya B. Joshi, Sarvajna Kumar Dwivedi
  • COMPOSITIONS, METHODS & SYSTEMS FOR RESPIRATORY DELIVERY OF TWO OR MORE ACTIVE AGENTS
    Publication number: 20120039817
    Abstract: Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
    Type: Application
    Filed: October 26, 2011
    Publication date: February 16, 2012
    Applicant: PEARL THERAPEUTICS, INC.
    Inventors: Reinhard Vehring, Michael Steven Hartman, David Lechuga-Ballesteros, Adrian Edward Smith, Vidya B. Joshi, Sarvajna Kumar Dwivedi
  • COMPOSITIONS FOR PULMONARY DELIVERY OF LONG-ACTING B2 ADRENERGIC RECEPTOR AGONISTS AND ASSOCIATED METHODS AND SYSTEMS
    Publication number: 20110132356
    Abstract: Compositions, methods and systems are provided for pulmonary delivery of long-acting muscarinic antagonists and long-acting ?2 adrenergic receptor agonists via a metered dose inhaler. In particular embodiments, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
    Type: Application
    Filed: May 28, 2010
    Publication date: June 9, 2011
    Applicant: PEARL THERAPEUTICS, INC.
    Inventors: Reinhard Vehring, Michael Steven Hartman, Adrian Edward Smith, Vidya B. Joshi, Sarvajna Kumar Dwivedi
  • COMPOSITIONS FOR RESPIRATORY DELIVERY OF ACTIVE AGENTS AND ASSOCIATED METHODS AND SYSTEMS
    Publication number: 20110135737
    Abstract: Compositions, methods and systems are provided for pulmonary or nasal delivery of active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
    Type: Application
    Filed: May 28, 2010
    Publication date: June 9, 2011
    Applicant: PEARL THERAPEUTICS, INC.
    Inventors: Reinhard Vehring, Michael Steven Hartman, Adrian Edward Smith, Vidya B. Joshi, Sarvajna Kumar Dwivedi
  • COMPOSITIONS, METHODS & SYSTEMS FOR RESPIRATORY DELIVERY OF TWO OR MORE ACTIVE AGENTS
    Publication number: 20110132357
    Abstract: Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
    Type: Application
    Filed: May 28, 2010
    Publication date: June 9, 2011
    Applicant: PEARL THERAPEUTICS, INC.
    Inventors: Reinhard Vehring, Michael Steven Hartman, David Lechuga-Ballesteros, Adrian Edward Smith, Vidya B. Joshi, Sarvajna Kumar Dwivedi
  • PHARMACEUTICAL FORMULATION COMPRISING A WATER-INSOLUBLE ACTIVE AGENT
    Publication number: 20110070309
    Abstract: A method of preparing a pharmaceutical formulation comprises providing a solution comprising a first solvent, a second solvent, an active agent, and an excipient. The second solvent is less polar than the first solvent and the excipient is more soluble in water than the active agent. The first and second solvents are removed from the solution to produce particles comprising the active agent and the excipient. In one version, the excipient comprises an amino acid and/or a phospholipid. A pharmaceutical formulation made by a version of the invention comprises particles comprising an active agent and an excipient which at least partially encapsulates the active agent, wherein the excipient is more soluble in water than the active agent.
    Type: Application
    Filed: November 23, 2010
    Publication date: March 24, 2011
    Applicant: NOVARTIS PHARMA AG
    Inventors: Reinhard Vehring, Danforth P. Miller, David Lechuga-Ballesteros
  • COMPOSITIONS FOR PULMONARY DELIVERY OF LONG-ACTING MUSCARINIC ANTAGONISTS AND ASSOCIATED METHODS AND SYSTEMS
    Publication number: 20110023876
    Abstract: Compositions, methods and systems are provided for pulmonary delivery of long-acting muscarinic antagonists and long-acting ?2 adrenergic receptor agonists via a metered dose inhaler. In particular embodiments, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
    Type: Application
    Filed: May 28, 2010
    Publication date: February 3, 2011
    Applicant: PEARL THERAPEUTICS, INC.
    Inventors: Reinhard Vehring, Michael Steven Hartman, Adrian Edward Smith, Vidya B. Joshi, Sarvajna Kumar Dwivedi
  • Pharmaceutical formulation comprising a water-insoluble active agent
    Patent number: 7862834
    Abstract: A method of preparing a pharmaceutical formulation comprises providing a solution comprising a first solvent, a second solvent, an active agent, and an excipient. The second solvent is less polar than the first solvent and the excipient is more soluble in water than the active agent. The first and second solvents are removed from the solution to produce particles comprising the active agent and the excipient. In one version, the excipient comprises an amino acid and/or a phospholipid. A pharmaceutical formulation made by a version of the invention comprises particles comprising an active agent and an excipient which at least partially encapsulates the active agent, wherein the excipient is more soluble in water than the active agent.
    Type: Grant
    Filed: May 27, 2004
    Date of Patent: January 4, 2011
    Assignee: Novartis Pharma AG
    Inventors: Reinhard Vehring, Danforth P. Miller, David Lechuga-Ballesteros
  • PRESERVATION OF BIOACTIVE MATERIALS BY FREEZE DRIED FOAM
    Publication number: 20100297231
    Abstract: This invention provides methods, systems and compositions to preserve bioactive materials in a dried foam matrix. Methods provide non-boiling foam generation and penetration of preservative agents at temperatures near the phase transition temperature of the membranes. Bioactive materials can be preserved with high initial viability in a freeze-foam process employing low temperature secondary drying.
    Type: Application
    Filed: May 6, 2008
    Publication date: November 25, 2010
    Applicant: MEDIMMUNE, LLC
    Inventors: Reinhard Vehring, Yi Ao
  • Pharmaceutical formulation comprising a water-insoluble active agent
    Publication number: 20050003004
    Abstract: A method of preparing a pharmaceutical formulation comprises providing a solution comprising a first solvent, a second solvent, an active agent, and an excipient. The second solvent is less polar than the first solvent and the excipient is more soluble in water than the active agent. The first and second solvents are removed from the solution to produce particles comprising the active agent and the excipient. In one version, the excipient comprises an amino acid and/or a phospholipid. A pharmaceutical formulation made by a version of the invention comprises particles comprising an active agent and an excipient which at least partially encapsulates the active agent, wherein the excipient is more soluble in water than the active agent.
    Type: Application
    Filed: May 27, 2004
    Publication date: January 6, 2005
    Applicant: Nektar Therapeutics
    Inventors: Reinhard Vehring, Danforth Miller, David Lechuga-Ballesteros