Patents by Inventor Reinhardt B. Baudy
Reinhardt B. Baudy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7879825Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided where at least one of R2 or R3 is not hydrogen. The compounds of the present invention are N-methyl-D-aspartate (NMDA) receptor antagonists and are useful in treating a variety of conditions present in a mammal that benefit from inhibiting the NMDA receptor.Type: GrantFiled: June 1, 2007Date of Patent: February 1, 2011Assignee: Wyeth LLCInventors: Reinhardt B. Baudy, John A. Butera
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Patent number: 7253153Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided where at least one of R2 or R3 is not hydrogen. The compounds of the present invention are N-methyl-D-aspartate (NMDA) receptor antagonists and are useful in treating a variety of conditions present in a mammal that benefit from inhibiting the NMDA receptor.Type: GrantFiled: April 7, 2004Date of Patent: August 7, 2007Assignee: WyethInventors: Reinhardt B. Baudy, John A. Butera
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Patent number: 7229970Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.Type: GrantFiled: May 13, 2005Date of Patent: June 12, 2007Assignees: Elan Pharmaceuticals, Inc., WyethInventors: Eugene D. Thorsett, Christopher M. Semko, Dimitrios Sarantakis, Michael A. Pleiss, Anthony Kreft, Andrei W. Konradi, Francine S. Grant, Darren B. Dressen, Susan Ashwell, Reinhardt B. Baudy, Louis J. Lombardo
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Patent number: 6200994Abstract: Compounds useful for the treatment of disorders of the serotonin-affected neurological systems are provided which have the following formula: wherein: X is carbon or nitrogen; R1 and R2 are each, independently, hydrogen, halogen, CF3, alkyl, alkoxy, or MeSO24; R3 is hydrogen, halogen, or alkyl; R4 is hydrogen, alkyl, alkylaryl, or aryl; and R5 is hydrogen, halogen, CF3, CN, carbamide, or alkoxy; or pharmaceutically acceptable salts thereof.Type: GrantFiled: December 30, 1999Date of Patent: March 13, 2001Assignee: American Home Products CorpInventors: Richard E. Mewshaw, Reinhardt B. Baudy
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Patent number: 5864040Abstract: This invention provides a process for the preparation of a compound of formula I ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen, alkyl, alkoxy, trifluoromethyl, trifluoromethoxy, methanesulfonylamino, acetylamino, halo, cyano, nitro, or when taken together R.sup.1 and R.sup.2 represent a methylenedioxy or ethylenedioxy moiety;or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 23, 1996Date of Patent: January 26, 1999Assignee: American Home Products CorporationInventors: Reinhardt B. Baudy, Michel Bekhazi, Brian J. Bushell, deceased, by Judith Marion Bushell, executrix, Gloria Cheal
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Patent number: 5719153Abstract: This invention provides compounds having the structure ##STR1## wherein m=0-1; andn=0-1 or a pharmaceutically acceptable salt thereof when m and n=0, that are useful as neuroprotective agents.Type: GrantFiled: August 6, 1996Date of Patent: February 17, 1998Assignee: American Home Products CorporationInventors: Reinhardt B. Baudy, Theodore S. Sulkowski
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Patent number: 5610164Abstract: This invention provides compounds having the structure ##STR1## wherein R is hydrogen, alkyl, alkenyl, alkynyl, --COR.sup.2, phenyl, or phenylalkyl; the dotted line represents an optional double bond;R.sup.1 is hydrogen, --OH, OR.sup.3, or is absent if the optional double bond is present;R.sup.2 and R.sup.3 are each, independently, alkyl, alkenyl, alkynyl, phenyl, or phenylalkyl;R.sup.4 is hydrogen, --OR.sup.5, alkyl, alkenyl, alkynyl, --COR.sup.5, --CO.sub.2 R.sup.5, --CONR.sup.5 R.sup.6, perhaloalkyl, halogen, phenyl, or phenylalkyl;R.sup.5 and R.sup.6 are each, independently, hydrogen, alkyl, alkenyl, alkynyl, phenyl, or phenylalkyl; andn=0-2or a pharmaceutically acceptable salt thereof that are useful as antipsychotic, antidepressant and anxiolytic agents useful in the treatment and relief of the symptoms of these disease states.Type: GrantFiled: July 24, 1996Date of Patent: March 11, 1997Assignee: American Home Products CorporationInventors: Reinhardt B. Baudy, James A. Nelson, Mira A. Kanzelberger
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Patent number: 5602128Abstract: The compounds ##STR1## where R and R.sup.6 are members independently selected from the group consisting of H, CN, OR.sup.2, NO.sub.2, NR.sup.2 R.sup.3, NR.sup.2 COR.sup.3, NR.sup.2 COOR.sup.3, COR.sup.2, COOR.sup.2, CONR.sup.2 R.sup.3, SR.sup.2, SOR.sup.2, SO.sub.2 R.sup.2, SO.sub.2 NR.sup.2 R.sup.3, alkyl, alkenyl, alkynyl, perhaloalkyl, and a halogen; in which R.sup.2 and R.sup.3 are alkyl, alkenyl, alkynyl, phenyl, or benzyl; R.sup.4 is a member selected from the group consisting of H, alkyl, heteroalkyl, in which the hetero atom is oxygen, sulfur or nitrogen, alkenyl and alkynyl; R.sup.5 is ##STR2## where X is O, S or NR.sup.7 and R.sup.7 is H or alkyl and n is 1, 2, 3, 4, 5, or 6; or a pharmaceutically acceptable salt thereof, are useful anxiolytic/antidepressant agents.Type: GrantFiled: December 2, 1994Date of Patent: February 11, 1997Assignee: American Home Products CorporationInventors: Reinhardt B. Baudy, Scott C. Berta
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Patent number: 5541179Abstract: This invention relates to compounds useful as anxiolytic agents having the formula: ##STR1## where A is ##STR2## wherein X is O or S;R.sup.1 is selected from H, --CN, --OR.sup.3, --NO.sub.2, --NR.sup.3 R.sup.4, --NR.sup.3 COR.sup.4, --NR.sup.3 COOR.sup.4, --COR.sup.3, --COOR.sup.3, --CONR.sup.3 R.sup.4, --SR.sup.3, --SOR.sup.3, --SO.sub.2 R.sup.3, --SO.sub.2 NR.sup.3 R.sup.4, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, -perhalo-C.sub.1 -C.sub.6 -alkyl, F, Cl, Br, and I;R.sup.2 is selected from H, --COR.sup.3, --COOR.sup.3, --CONR.sup.3 R.sup.4, --CONHR.sup.3, --COCHR.sup.3 R.sup.4, C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 alkenyl, and C.sub.2 -C.sub.6 -alkynyl;R.sup.3 and R.sup.4 are independently selected from C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 alkynyl, benzyl, or phenyl which may be optionally substituted by one to three groups selected from F, Cl, Br, I, --NO.sub.2, --CN, and --C.sub.1 -C.sub.6 alkoxy; or R.sup.3 and R.sup.Type: GrantFiled: May 2, 1995Date of Patent: July 30, 1996Assignee: American Home Products CorporationInventors: Reinhardt B. Baudy, Scott C. Berta, Gary P. Stack
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Patent number: 5525600Abstract: This invention provides compounds having the structure ##STR1## wherein R is hydrogen, alkyl, alkenyl, alkynyl, --COR.sup.2, phenyl, or phenylalkyl of 7-10 carbon atoms;the dotted line represents an optional double bond;R.sup.1 is hydrogen, --OH, OR.sup.3, or is absent if the optional double bond is present;R.sup.2 and R.sup.3 are each, independently, alkyl, alkenyl, alkynyl, phenyl, or phenylalkyl;R.sup.4 is hydrogen, --OR.sup.5, alkyl, alkenyl, alkynyl, --COR.sup.5, --CO.sub.2 R.sup.5, --CONR.sup.5 R.sup.6, perhaloalkyl, halogen, phenyl, or phenylalkyl;R.sup.5 and R.sup.6 are each, independently, hydrogen, alkyl, alkenyl, alkynyl, phenyl, or phenylalkyl; andn=0-2or a pharmaceutically acceptable salt thereof that are useful as antipsychotic, antidepressant and anxiolytic agents useful in the treatment and relief of the symptoms of these disease states.Type: GrantFiled: November 28, 1994Date of Patent: June 11, 1996Assignee: American Home Products CorporationInventor: Reinhardt B. Baudy
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Patent number: 5451584Abstract: The compounds ##STR1## where: R and R.sup.6 are members independently selected from the group consisting of H, CN, OR.sup.2, NO.sub.2, NR.sup.2 R.sup.3, NR.sup.2 COR.sup.3, NR.sup.2 COOR.sup.3, COR.sup.2, COOR.sup.2, CONR.sup.2 R.sup.3, SR.sup.2, SOR.sup.2, SO.sub.2 R.sup.2, SO.sub.2 NR.sup.2 R.sup.3, alkyl, alkenyl, alkynyl, perhaloalkyl, and a halogen;in which R.sup.2 and R.sup.3 are alkyl, alkenyl, alkynyl, phenyl, or benzyl;R.sup.4 is a member selected from the group consisting of H, alkyl, heteroalkyl, in which the hetero atom is oxygen, sulfur or nitrogen, alkenyl and alkynyl;R.sup.5 is alkynyl of 2 to 8 carbon atoms or 1-alkynylcycloalkyl in which the alkynyl group contains 2 to 6 carbon atoms and the cycloalkyl group contains 3 to 10 carbon atoms;or a pharmaceutically acceptable salt thereof, are useful anxiolytic/antidepressant agents.Type: GrantFiled: November 10, 1994Date of Patent: September 19, 1995Assignee: American Home Products CorporationInventors: Reinhardt B. Baudy, Scott C. Berta
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Patent number: 5124319Abstract: The compounds of the formula ##STR1## wherein R is hydrogen, lower alkyl, benzyl or pivaloyloxymethyl;R.sup.1 and R.sup.2 are, independently, hydrogen, lower alkyl, lower alkoxy, trifluoromethyl, trifluoromethoxy, methanesulfonylamino, acetylamino, or halo, or when taken together R.sup.1 and R.sup.2 represent a methylenedioxy grouping;and the pharmacologically acceptable salts thereof are NMDA antagonists useful in the treatment and prevention of central nervous system related pathological conditions resulting from overstimulation by excitatory amino acids.Type: GrantFiled: October 11, 1991Date of Patent: June 23, 1992Assignee: American Home Products CorporationInventors: Reinhardt B. Baudy, Horace Fletcher, III, John P. Yardley
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Patent number: 5118675Abstract: The compounds of the formula: ##STR1## in which Q is the quinoxaline nucleus; m is one of the integers 0, 1 or 2; n is one of the integers 1,2 or 3; or a pharmaceutically acceptable salt, alkyl ester or ##STR2## where R.sup.3 and R.sup.4 are, independently, hydrogen, nitro, halo or methoxy, are NMDA antagonists useful in the treatment and prevention of central nervous system related pathological conditions resulting from overstimulation by excitatory amino acids.Type: GrantFiled: February 15, 1991Date of Patent: June 2, 1992Assignee: American Home Products CorporationInventors: Ivo L. Jirkovsky, Reinhardt B. Baudy, Lynne P. Greenblatt