Abstract: The compound of the formula: ##STR1## where R is H, alkyl, haloalkyl, cycloalkyl, alkenyl or alkynyl; Y is oxygen, sulfur or NR.sub.2 where R.sub.2 is H or alkyl; or a pharmaceutically acceptable salt thereof, are centrally active muscarinic agents.

Abstract: The compounds of the formula: ##STR1## where R is H, alkyl, haloalkyl, cycloalkyl, alkenyl or alkynyl; Y is oxygen, sulfur or NR.sub.2 where R.sub.2 is H or alkyl; or a pharmaceutically acceptable salt thereof, are useful centrally active muscarinic agents.

Abstract: The compound of the formula: ##STR1## where R is H, alkyl, haloalkyl, cycloalkyl, alkenyl or alkynyl; Y is oxygen, sulfur or NR.sub.2 where R.sub.2 is H or alkyl; or a pharmaceutically acceptable salt thereof, are centrally active muscarinic agents.

Abstract: The compounds: ##STR1## in which R.sup.1 is hydrogen, halogen, hydroxy, or alkyl;R.sup.2 is substituted or unsubstituted pyridinyl, pyrazinyl, quinolinyl or quinoxalinyl and said substituents are alkyl, alkoxy, alkoxycarbonyl, halogen, cyano or nitro;R.sup.5 and R.sup.6 are, independently, hydrogen, alkyl, phenyl, halophenyl, methylphenyl, trifluoromethylphenyl, cyanophenyl or nitrophenyl; with the proviso that one of R.sup.5 and R.sup.6 is other than hydrogen;and n is an integer from 1 to 7;or a pharmaceutically acceptable salt thereof, are antipsychotic and anxiolytic agents.

Abstract: This application provides a novel process for the synthesis of 3-(2-hydroxy-2-phenylethyl)-N-[(phenylamino)carbonyl]sydnonimine derivatives and novel hydrophobic and hydrophilic acyl derivatives thereof as pro-drug central nervous system stimulants.

Abstract: The disclosed [[2-(substituted amino)-2-phenylethyl]nitrosoamino]acetonitrile derivatives and the ring closed oxadiazolium salts thereof as well as their pharmaceutically acceptable acid addition salts are antihypertensive agents useful in the treatment of hypertension.

Abstract: A compound of the formula: ##STR1## in which R.sup.1 and R.sup.2 are, independently, hydrogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, halo, perfluoroalkyl of 1 to 3 carbon atoms, nitro, alkanoyl of 2 to 4 carbon atoms or alkoxycarbonyl of 2 to 4 carbon atoms;R.sup.3 is hydrogen, halo, nitro or alkanoyl of 2 to 4 carbon atoms;R.sup.4 is hydrogen, halo, nitro or perfluoroalkyl of 1 to 3 carbon atoms;R.sup.5 and R.sup.6 are, independently, hydrogen, methyl or ethyl;or a non-toxic acid addition salt thereof, are central nervous system stimulants.

Abstract: 3-[Methyl(phenylmethyl)amino]-N-[(phenylamino)carbonyl]sydnone imine or a pharmaceutically acceptable salt thereof serve as central nervous system stimulants with much less sympathomimetic activity than is found in amphetamine like stimulants.

Abstract: The disclosed [[2-(substituted amino)-2-phenylethyl]-nitrosoamino]acetonitrile derivatives and the ring closed oxadiazolium salts thereof as well as their pharmaceutically acceptable acid addition salts are antihypertensive agents useful in the treatment of hypertension.

Abstract: This application provides a novel process for the synthesis of 3-[1(hydroxymethyl)-2-phenylethyl]-N-[(phenylamino)carbonyl]sydnonimine derivatives and novel hydrophobic and hydrophilic acyl derivatives thereof as pro-drug central nervous system stimulants.

Abstract: A compound of the formula: ##STR1## in which R.sup.1 and R.sup.2 are, independently, hydrogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, halo, perfluoroalkyl of 1 to 3 carbon atoms, nitro, alkanoyl of 2 to 4 carbon atoms or alkoxycarbonyl of 2 to 4 carbon atoms;R.sup.3 is hydrogen, halo, nitro or alkanoyl of 2 to 4 carbon atoms;R.sup.4 is hydrogen, halo, nitro or perfluoroalkyl of 1 to 3 carbon atoms;R.sup.5 and R.sup.6 are, independently, hydrogen or methyl; andR.sup.7 and R.sup.8 are, independently, alkyl of 1 to 4 carbon atoms, or when taken with the nitrogen atom to which they are attached form a piperidinyl, pyrolidinyl, morpholinyl, N-alkyl piperazinyl in which the alkyl group contains from 1 to 6 carbon atoms or N-phenylpiperazinyl group ora non-toxic acid addition salt thereof, are central nervous system stimulants.

Abstract: A compound of the formula: ##STR1## in which the enantiomeric form is d,1 or 1- when R.sup.5 is hydrogen and d,1 or 1-threo when R.sup.5 is other than hydrogen;R.sup.1 and R.sup.2 are, independently, hydrogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, halo, perfluoroalkyl of 1 to 3 carbon atoms, nitro, alkanoyl of 2 to 4 carbon atoms or alkoxycarbonyl of 2 to 4 carbon atoms;R.sup.3 is hydrogen, halo, nitro or alkanoyl of 2 to 4 carbon atoms;R.sup.5 and R.sup.6 are, independently, hydrogen or methyl;or a non-toxic acid addition salt thereof, are central nervous system stimulants.

Abstract: 5,6,7,12-Tetrahydro-5,12-methanodibenz[c,f]azocines substituted in the 6-position by a di(lower)alkylaminoacetyl or a di(lower)alkylaminoethyl group inhibit stress-induced ulcers. Also described are intermediates and processes for preparing the anti-ulcer compounds.

Abstract: An efficient, one-step process for preparing 13-alkyl-17.alpha. alkyl, alkenyl, or alkynyl-17.beta.-acyloxy-4-en-3-one steroids from their corresponding 13-alkyl-17.alpha.-substituted-3-alkoxygona-2,5(10)-dien-17.beta.-ols is disclosed. Products of the instant process possess, for example, progestational activity.