Abstract: The invention relates to a container having a wall structure comprising a polymer material including an acid diffusion barrier. The invention also relates to a use of a cycloolefin polymer, COP, and/or a cycloolefin copolymer, COC, as an acid diffusion barrier polymer in a container for an acid. The invention further relates to a use of such a container and to a system for providing a medical solution comprising at least one container according to the invention. Finally the invention relates to a method for treatment by means of a container according to the invention.

Abstract: A polymer affinity matrix for the binding of one or more substances in a fluid for removing said substance(s) from the fluid and/or decreasing the amount or concentration thereof in said fluid with a view to preventing, eliminating, or reducing undesired activation of components in said fluid is described, as well as a method for removing said substance(s) from the fluid and/or decreasing the amount or concentration thereof in said fluid, a method for the production of said matrix, use of said matrix and a kit comprising said matrix. The polymer affinity matrix comprises a solid support, a space and a ligand, containing arginine as a binding unit.

Abstract: This invention discloses methods and devices useful for eliminating or reducing the adverse effects associated with the use of a variety of therapeutic fluids. It is proposed herein that the source of such side effects (e.g. fever and septic shock) is the oligonucleotides present in the fluid and that using the ultrafiltration and adsorption methods and devices disclosed in the invention one can minimize the risk of these adverse effects often associated with dialysis treatment.

Abstract: A process for production of a microporous affinity membrane having regioselective affinity for compounds in blood or other biologically active fluids to be removed during purification of blood or said fluids is disclosed, as well as a microporous affinity membrane produced by said process, an adsorption device containing such a microporous affinity membrane, and use of such a microporous affinity membrane.

Abstract: The present invention includes a co-polymer film which can be applied over a surface of an article to form a continuous surface that is more biocompatible and has a smoother surface morphology than an untreated article. In general the co-polymer film of the invention can be formed by providing a hydrophobic polymer block, such as polydimethylsiloxane (PDMS) with functional —OH end groups and reacting the —OH ends with a conventional monomer or prepolymer of a film-forming polymer capable of reacting with —OH groups. Such reactions are exemplified, using as reactive PDMS a triblock copolymer of the polylactone-polysiloxane-polylactone (PL-PDMS-PL) type, or silicone polyesters. The —OH groups of the polylactone blocks can react with any of a variety of isocyanates in a suitable solvent to form a polymer having PDMS incorporated with its structure.

Abstract: The present invention relates to a method of reducing decline of renal function or preserving residual renal function of a subject, particularly, those with impaired renal function, by regulating the amount of carbohydrate-derived toxins that is administered thereto, or is present in the body of such a subject. The method involves administering a product containing reduced amount of carbohydrate-derived toxins to such a subject or a product capable of removing or reducing such toxins in the body of the subject upon administration. Examples of the products useful for the invention include various dialysis fluids, particularly peritoneal dialysis fluids, and food or nutritional fluids containing reduced amount of carbohydrate-derived toxins that can be administered to a patient with impaired renal function.

Abstract: A device and method for detoxifying a carbohydrate containing solution. A method for identification and determination of the toxicity of a carbohydrate containing medical solution and a carbohydrate containing medical solution as such. A method for detoxifying a carbohydrate containing cell cultivation fluid or food in fluid form; a method for the production of 3,4-dideoxy-glucosone-3-ene and use of a 3,4-dideoxy-glucosone-3-ene detoxifying agent for the production of a medical solution for the treatment of diseases involving disturbed carbohydrate metabolism or compromised removal of carbohydrate degration products.

Abstract: This invention provides methods and compositions for using nitric oxide in a photoradiation pathogen inactivation process for whole blood and blood components to improve pathogen kill and to improve preservation of the quality of the blood components. This invention provides methods for using nitric oxide in combination with oxygen, photosensitizers, quencher and/or glycolysis inhibitor, and compositions comprising blood components decontaminated by these methods. Nitric oxide is provided using nitric oxide gas, or nitric oxide generators such as L-arginine, and/or N-acetyl-cysteine. This invention also provides compositions suitable for photoradiation pathogen inactivation that include fluid comprising a blood component, a photosensitizer, and dissolved nitric oxide. This invention provides decontamination systems useful for performing the methods of this invention and methods for making the decontamination systems.

Abstract: The present invention includes a co-polymer film which can be applied over a surface of an article to form a continuous surface that is more biocompatible and has a smoother surface morphology than an untreated article. In general the co-polymer film of the invention can be formed by providing a hydrophobic polymer block, such as polydimethylsiloxane (PDMS) with functional —OH end groups and reacting the —OH ends with a conventional monomer or prepolymer of a film-forming polymer capable of reacting with —OH groups. Such reactions are exemplified, using as reactive PDMS a triblock copolymer of the polylactone-polysiloxane-polylactone (PL-PDMS-PL) type, or silicone polyesters. The —OH groups of the polylactone blocks can react with any of a variety of isocyanates in a suitable solvent to form a polymer having PDMS incorporated with its structure.

Abstract: The present invention includes a co-polymer film which can be applied over a surface of an article to form a continuous surface that is more biocompatible and has a smoother surface morphology than an untreated article. In general the co-polymer film of the invention can be formed by providing a hydrophobic polymer block, such as polydimethylsiloxane (PDMS) with functional —OH end groups and reacting the —OH ends with a conventional monomer or prepolymer of a film-forming polymer capable of reacting with —OH groups. Such reactions are exemplified, using as reactive PDMS a triblock copolymer of the polylactone-polysiloxane-polylactone (PL-PDMS-PL) type, or silicone polyesters. The —OH groups of the polylactone blocks can react with any of a variety of isocyanates in a suitable solvent to form a polymer having PDMS incorporated with its structure.

Abstract: Use of a solution comprising glucose for peritoneal dialysis, in which the glucose portion is sterilised separately from the remaining components at a high glucose concentration above about 20% and mixed after sterilisation, substantially according to WO 93/09820. The solution has a reduced formation of advanced glycosylation end products and the use is indicated for diabetic uremic patients.

Abstract: Membranes composed of sulphonated polyaryl ether sulphones are disclosed in which the repetitive polymer units have the formula ##STR1## in which the aryl radicals are substituted by SO.sub.3 X where X is hydrogen or an alkali metal and the polymer includes from about 0.3 to 0.6 SO.sub.3 X radicals per unit. Processes for producing these membranes are also disclosed.