Patents by Inventor Reinhold Knoll

Reinhold Knoll has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11857302
    Abstract: The invention refers to a method of determining an indicator that is representative for a patient's volume responsiveness, comprising the following steps: (i) measuring a sequence of pulse signals of a patient; (ii) determining an envelope(signal)-curve based on the sequence of measured pulse signals; (iii) determining a fit(envelope(signal))-function based on the previously determined envelope(signal)-curve, the fit(envelope(signal))-function representing an idealised curve progression of the envelope(signal)-curve without comprising pulse variations caused by ventilation or respiration induced heart-lung interaction; (iv) determining respiratory pulse variation signals corresponding to the pulse variations caused by ventilation or respiration induced heart-lung interaction; (v) determining an envelope(respiration)-curve based on the previously determined respiratory pulse variation signals; (vi) determining a fit(envelope(respiration))-function based on the previously determined envelope(respiration)-curve,
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: January 2, 2024
    Assignee: PHILIPS MEDIZIN SYSTEME BÖBLINGEN GMBH
    Inventor: Reinhold Knoll
  • Publication number: 20220257130
    Abstract: The present invention refers to a blood pressure measuring system (10) configured to surround a patient's body part (E), comprising pressurization means (12, 14) for applying pressure to the body part (E), and comprising a kinking-proof shell (20; 30), wherein the kinking-proof shell (20; 30) is arranged so as to be located between the pressurization means (12, 14) and the body part (E), when the blood pressure measuring system (10) surrounds the body part (E). The present invention further refers to a method of applying a blood pressure measuring system (10).
    Type: Application
    Filed: May 3, 2022
    Publication date: August 18, 2022
    Inventors: ULRICH PFEIFFER, SABASTIAN KISBAN, TOBIAS THOMAMÜLLER, ANNA-LUISA UHLITZ, REINHOLD KNOLL
  • Patent number: 11317819
    Abstract: The present invention refers to a blood pressure measuring system (10) configured to surround a patient's body part (E), comprising pressurization means (12, 14) for applying pressure to the body part (E), and comprising a kinking-proof shell (20; 30), wherein the kinking-proof shell (20; 30) is arranged so as to be located between the pressurization means (12, 14) and the body part (E), when the blood pressure measuring system (10) surrounds the body part (E). The present invention further refers to a method of applying a blood pressure measuring system (10).
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: May 3, 2022
    Assignee: Philips Medizin Systeme Böblingen GmbH
    Inventors: Ulrich Pfeiffer, Sebastian Kisban, Tobias Thomamüller, Anna-Luisa Uhlitz, Reinhold Knoll
  • Publication number: 20220015718
    Abstract: In an approach to non-invasive blood pressure measurements, a blood pressure measurement system receives a pulse curve signal representing a sequence of pulse curves of a subject from a pressure cuff. The blood pressure measurement system applies a weighting function that applies one or more weights to a pulse curve of the sequence of pulse curves to obtain a weighted pulse curve and the one or more non-constant clamp pressure signals are a weighting function input parameter. The blood pressure measurement system sums at least the weighted pulse curve and a second weighted pulse curve, which approximates a shape and an amplitude of a pulse wave of the subject. The blood pressure measurement system determines a health status of the subject based on the pulse wave and generates a graphical representation of the pulse wave of the subject and the health status of the subject.
    Type: Application
    Filed: September 14, 2021
    Publication date: January 20, 2022
    Inventors: Reinhold KNOLL, Ulrich PFEIFFER
  • Patent number: 10485432
    Abstract: The invention relates to a method for determining blood pressure in a blood vessel, according to which a pulse wave propagation time is caluculated in a measuring operation by means of at least two sensors arranged at a defined distance from one another. The method is characterized in that the blood pressure is calculated using a calibration carried out by means of a compression pressure measurement.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: November 26, 2019
    Assignee: PHILIPS MEDIZIN SYSTEME BÖBLINGEN GMBH
    Inventors: Ulrich Pfeiffer, Reinhold Knoll
  • Publication number: 20190336015
    Abstract: The invention refers to a method of determining an indicator that is representative for a patient's volume responsiveness, comprising the following steps: (i) measuring a sequence of pulse signals of a patient; (ii) determining an envelope(signal)curve based on the sequence of measured pulse signals; (iii) determining a fit(envelope(signal))-function based on the previously determined envelope(signal)-curve, the fit(envelope(signal))-function representing an idealised curve progression of the envelope(signal)-curve without comprising pulse variations caused by ventilation or respiration induced heart-lung interaction; (iv) determining respiratory pulse variation signals corresponding to the pulse variations caused by ventilation or respiration induced heart-lung interaction; (v) determining an envelope(respiration)-curve based on the previously determined respiratory pulse variation signals; (vi) determining a fit(envelope(respiration))-function based on the previously determined envelope(respiration)-curve,
    Type: Application
    Filed: July 15, 2019
    Publication date: November 7, 2019
    Inventor: Reinhold Knoll
  • Patent number: 10349849
    Abstract: The invention refers to a method of determining an indicator that is representative for a patient's volume responsiveness, comprising the following steps: (i) measuring a sequence of pulse signals of a patient; (ii) determining an envelope(signal)-curve based on the sequence of measured pulse signals; (iii) determining a fit(envelope(signal))-function based on the previously determined envelope(signal)-curve, the fit(envelope(signal))-function representing an idealized curve progression of the envelope(signal)-curve without comprising pulse variations caused by ventilation or respiration induced heart-lung interaction; (iv) determining respiratory pulse variation signals corresponding to the pulse variations caused by ventilation or respiration induced heart-lung interaction; (v) determining an envelope(respiration)-curve based on the previously determined respiratory pulse variation signals; (vi) determining a fit(envelope(respiration))-function based on the previously determined envelope(respiration)-curve,
    Type: Grant
    Filed: January 9, 2014
    Date of Patent: July 16, 2019
    Assignee: PHILIPS MEDIZIN SYSTEME BÖBLINGEN
    Inventor: Reinhold Knoll
  • Publication number: 20170112396
    Abstract: The invention relates to a method for determining blood pressure in a blood vessel, according to which a pulse wave propagation time is caluculated in a measuring operation by means of at least two sensors arranged at a defined distance from one another. The method is characterized in that the blood pressure is calculated using a calibration carried out by means of a compression pressure measurement.
    Type: Application
    Filed: April 4, 2014
    Publication date: April 27, 2017
    Applicant: Up-Med GmbH
    Inventors: Ulrich Pfeiffer, Reinhold Knoll
  • Patent number: 9375159
    Abstract: The invention relates to indicator dilution measurements of a central volume (V1) with a first site of injection (S1) upstream of the central volume (V1) a second site of detection (S2) of the diluted indicator downstream of the central volume (V1), wherein a first additional volume (V2) is defined between the first site (S1) and the central volume (V1) and a first additional branch (B2) is defined between the first site (S1) and the central volume (V1) and wherein a second additional volume (V3) is defined between the central volume (V1) and the second site (S2) and a second additional branch (B3) is defined between the central volume (V1) and the second site (S2) wherein a result of central volumetric parameters are corrected for the first and second additional volumes (V2, V3) and/or for the first and second additional branches (B2, B3).
    Type: Grant
    Filed: October 15, 2008
    Date of Patent: June 28, 2016
    Assignee: Edwards Lifesciences IPRM AG
    Inventors: Ulf Borg, Reinhold Knoll, Frederic Michard, Ulrich Pfeiffer
  • Publication number: 20150359446
    Abstract: The present invention refers to a blood pressure measuring system (10) configured to surround a patient's body part (E), comprising pressurization means (12, 14) for applying pressure to the body part (E), and comprising a kinking-proof shell (20; 30), wherein the kinking-proof shell (20; 30) is arranged so as to be located between the pressurization means (12, 14) and the body part (E), when the blood pressure measuring system (10) surrounds the body part (E). The present invention further refers to a method of applying a blood pressure measuring system (10).
    Type: Application
    Filed: February 7, 2014
    Publication date: December 17, 2015
    Inventors: Ulrich Pfeiffer, Sebastian Kisban, Tobias Thomamüller, Anna-Luisa Uhlitz, Reinhold Knoll
  • Publication number: 20150359442
    Abstract: The invention refers to a method of determining an indicator that is representative for a patient's volume responsiveness, comprising the following steps: (i) measuring a sequence of pulse signals of a patient; (ii) determining an envelope(signal)-curve based on the sequence of measured pulse signals; (iii) determining a fit(envelope(signal))-function based on the previously determined envelope(signal)-curve, the fit(envelope(signal))-function representing an idealised curve progression of the envelope(signal)-curve without comprising pulse variations caused by ventilation or respiration induced heart-lung interaction; (iv) determining respiratory pulse variation signals corresponding to the pulse variations caused by ventilation or respiration induced heart-lung interaction; (v) determining an envelope(respiration)-curve based on the previously determined respiratory pulse variation signals; (vi) determining a fit(envelope(respiration))-function based on the previously determined envelope(respiration)-curve,
    Type: Application
    Filed: January 9, 2014
    Publication date: December 17, 2015
    Applicant: UP-MED GmbH
    Inventor: Reinhold Knoll
  • Publication number: 20150320364
    Abstract: The present invention refers to a method of approximating a patient's pulse wave based on non-invasive blood pressure measurement, comprising the following steps: (a) non-invasively measuring a sequence n?1 . . . N of pulse signals pulsen—measured(t) of a patient, thereby applying a clamp pressure clampn(t), (b) weighting the measured pulse signals pulsen measured(t) using a weighting function to obtain weighted pulse signals pulsen weighted(t), and (c) adding up the weighted pulse signals pulsen weighted(t) to obtain an approximation of the patient's pulse wave pulseapprox(t). The invention also refers to a logic unit and a system for approximating a patient's pulse wave based on non-invasive blood pressure measurement.
    Type: Application
    Filed: January 9, 2014
    Publication date: November 12, 2015
    Inventors: Reinhold Knoll, Ulrich Pfeiffer
  • Patent number: 8998817
    Abstract: A blood pressure measuring device includes a flexible element configured to at least partially surround a body part and having a stiffening element configured to stiffen the flexible element; and at least one pressure sensor element attached to the flexible element.
    Type: Grant
    Filed: August 27, 2010
    Date of Patent: April 7, 2015
    Assignee: UP-MED GmbH
    Inventors: Ulrich Pfeiffer, Tobias Thomamueller, Reinhold Knoll
  • Publication number: 20150080751
    Abstract: Blood pressure measuring device with a flexible pressure collar, to surround a body part at least partially, with a pressure sensor element, wherein the shape of the pressure collar can be adapted to the outer contour of the body part, the pressure collar being at least partially inelastic. Further, the flexible pressure collar for a blood pressure measuring device to the relates pressure collar being inelastic and the shape being adapted to the outer contour of a body part. A method for non-invasive blood pressure measurement on a patient's body part with a blood pressure measuring device includes: positioning the pressure collar on the body part; setting the pressure collar such that it exerts pressure in the pulsatile region of the patient on the body part; and recording the pulsation for the period of at least one breathing cycle of the patient in the form of pulsation signals.
    Type: Application
    Filed: February 3, 2012
    Publication date: March 19, 2015
    Inventors: Stephan Regh, Tobias Thomamueller, Reinhold Knoll, Ulrich Pfeiffer
  • Publication number: 20150080750
    Abstract: The invention relates to a disposable sensor device (51) for patient monitoring comprising a sensor (52) for providing an electric quantity based on a quantity to be detected, a first signal terminal (54) for providing a tap for the electric quantity, a first supply terminal (53) for supplying the sensor with an electrical supply quantity, a first connector for accommodating the first signal terminal (54) and the first supply terminal (53), a second signal terminal (56) for providing a further tap for the electric quantity, and a second connector for accommodating at least the second signal terminal (56).
    Type: Application
    Filed: November 19, 2014
    Publication date: March 19, 2015
    Applicant: Edwards Lifesciences IPRM AG
    Inventors: Ulrich Pfeiffer, Reinhold Knoll, Tobias Thomamuller, Frederic Michard, Matthias Fahle
  • Patent number: 8920329
    Abstract: The invention relates to a disposable sensor device (51) for patient monitoring comprising a sensor (52) for providing an electric quantity based on a quantity to be detected, a first signal terminal (54) for providing a tap for the electric quantity, a first supply terminal (53) for supplying the sensor with an electrical supply quantity, a first connector for accommodating the first signal terminal (54) and the first supply terminal (53), a second signal terminal (56) for providing a further tap for the electric quantity, and a second connector for accommodating at least the second signal terminal (56).
    Type: Grant
    Filed: February 19, 2008
    Date of Patent: December 30, 2014
    Assignee: Edwards Lifesciences IPRM AG
    Inventors: Reinhold Knoll, Frederic Michard, Matthias Fahle, Tobias Thomamüller, Ulrich Pfeiffer
  • Patent number: 8858451
    Abstract: An injection system for injecting an injectate fluid into a blood vessel of the patient and for carrying out a blood pressure measurement of a patient. The injection system includes a catheter tube having a first end for penetrating the blood vessel of the patient, and a pressure sensor which is arranged close to a second end of the catheter tube and can sense a pressure of a liquid in the catheter tube as an indication of the blood pressure of the patient.
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: October 14, 2014
    Assignee: Edwards Lifesciences IPRM AG
    Inventors: Ulrich Pfeiffer, Daniel Moulas, Reinhold Knoll
  • Patent number: 8849366
    Abstract: A catheter system includes a flexible, elongated base body adapted to be applied to a vein central-venously and having a base distal end; a fiber-optic probe having a probe distal part; a fiber-optic lumen receiving the fiber-optic probe; and an attachment element configured to avoid a longitudinal displacement of the fiber-optic probe relative to the fiber-optic lumen and configured to detach so as to allow removal of the fiber-optic probe through the longitudinal displacement of the fiber-optic probe relative to the fiber-optic lumen. The attachment element has a connector piece firmly connected to the fiber-optic probe and a counter-piece firmly connected to the base body, wherein the connector piece is connectable to the counter-piece, the connector piece having a shaft piece adjustable lengthwise and disposed on the connector piece so as to vary a length of the connector piece.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: September 30, 2014
    Assignee: Up-Med GmbH
    Inventors: Ulrich Pfeiffer, Daniel Moulas, Reinhold Knoll
  • Publication number: 20140239937
    Abstract: A connector system includes a first connector having a plurality of first contact terminals, and a second connector having a plurality of second contact terminals. The second contact terminals are arranged such that, while connecting, the first contact terminals come into contact with a first subset of the plurality of second contact terminals in a first connecting stage. As the connection proceeds further the first contact terminals come into contact with a second subset of the second contact terminals. In the first connecting stage an electrical quantity between two of the first contact terminals is detectable. This electrical quantity is different from an electrical quantity in an uncoupled condition of the connectors. In the second connecting stage a further electrical quantity between at least two of the first contact terminals is detectable and different from the electrical quantity detected in the first connecting stage.
    Type: Application
    Filed: December 2, 2013
    Publication date: August 28, 2014
    Applicant: Edwards Lifesciences IPRM AG
    Inventors: Ulrich Pfeiffer, Reinhold Knoll, Tobias Thomamuller
  • Patent number: 8608683
    Abstract: A device for infusing of at least one medicament includes at least two actuators configured to cause at least two medicaments to be infused; at least one sensor configured to measure a value of at least two parameters; and a controller configured to control the at least two actuators, wherein the controller is programmed to activate the at least two actuators depending on the values of each of the at least two parameters, and wherein the controller is arranged so as to consider a dependency of the at least two medicaments.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: December 17, 2013
    Assignee: UP-Med GmbH
    Inventors: Frederic Michard, Ulrich Pfeiffer, Reinhold Knoll