Abstract: The present invention is directed to transdermal therapeutic systems that are free of fibrous constituents, as well methods for producing such transdermal therapeutic systems. A preparation containing active substance is applied by a printing method onto the pressure-sensitive adhesive layer of the transdermal therapeutic system. Exemplary printing methods include application methods based upon a distributor plate of an application device.

Abstract: A transdermal therapeutic system which is free of fibrous constituents, and a method for the production of such a transdermal therapeutic system A preparation containing active substance is applied by a printing method onto the pressure-sensitive adhesive layer of the transdermal therapeutic system.

Abstract: The present invention is directed to transdermal therapeutic systems that are free of fibrous constituents, as well methods for producing such transdermal therapeutic systems. A preparation containing active substance is applied by a printing method onto the pressure-sensitive adhesive layer of the transdermal therapeutic system. Exemplary printing methods include application methods based upon a distributor plate of an application device.

Abstract: A transdermal therapeutic system which is free of fibrous constituents, and a method for the production of such a transdermal therapeutic system A preparation containing active substance is applied by a printing method onto the pressure-sensitive adhesive layer of the transdermal therapeutic system.

Abstract: A transdermal therapeutic system in patch form for the controlled delivery of active substances to the human or animal skin comprises a backing layer, an active substance-containing reservoir attached thereto and a detachable protective layer, is characterized in that the active substance-containing reservoir contains as main components thereof at least one film former as well as at least one polymer which prevents or suppresses the crystallisation of the active substance or active substances.

Abstract: A transdermal therapeutic system in plaster form for controlled release of oestradiol in combination with norethisterone acetate, comprising a backing layer, a reservoir supersaturated with active ingredients which is attached to said backing layer and prepared using polyacrylate pressure-sensitive adhesives and crystallization inhibitors, and a detachable protective layer, is characterized in that the crystallization inhibitor is an amino-containing polymer.

Abstract: A dermal or transdermal therapeutic system comprising a sheet-like substrate or reservoir containing readily volatile auxiliary agents or active agents, which substrate or reservoir is covered on one of its sides with a backing layer impermeable to the ingredients and on the opposite side with a detachable, likewise impermeable protective layer to prevent loss of ingredients during prolonged storage, is characterized in that both the backing layer and the protective layer are made of plastic film which is on both sides with vapour-deposited metal

Abstract: A transdermal therapeutic system in patch form for the controlled delivery of active substances to the human or animal skin comprises a backing layer, an active substance-containing reservoir attached thereto and a detachable protective layer, is characterized in that the active substance-containing reservoir contains as main components thereof at least one film former as well as at least one polymer which prevents or suppresses the crystallisation of the active substance or active substances.

Abstract: An active substance-containing patch for controlled release of estradiol or its pharmaceutically acceptable derivatives, alone or in combination with gestagens, to the human or animal skin, consisting of a backing layer, an active substance-containing reservoir connected thereto which is suitable for combined active substance release and which has been produced using pressure-sensitive adhesives, and a detachable protective layer, is characterized in that the pressure-sensitive adhesive contains wool wax or components thereof and zinc oxide.

Abstract: An active-substance-containing transdermal therapeutic system for the controlled release of estradiol or its pharmaceutically acceptable able derivatives alone or combined with gestagens consisting of a layer, an active-substance-containing reservoir which is bonded thereto and produced by using pressure sensitive adhesives, and a removable protective layer is characterized by the fact that the pressure sensitive adhesive comprises esters of colophony.

Abstract: An active-substance-containing transdermal therapeutic system for the controlled release of estradiol or its pharmaceutically acceptable derivatives alone or combined with gestagens consisting of a backing layer, an active-substance-containing reservoir which is bonded thereto and produced by using pressure sensitive adhesives, and a removable protective layer is characterized by the fact that the pressure sensitive adhesive comprises esters of colophony.

Abstract: An active compound-containing patch for the controlled delivery of oestradiol or its pharmaceutically acceptable derivatives, alone or in combination with gestagens, to human or animal skin, having an active compound-containing reservoir based on ethylcellulose and contact adhesives comprising adhesive resins is characterized by a contact adhesive having a high plasticizer content.

Abstract: Process for the production, transport and storage of a therapeutic system which is in the form of a plaster and has an active layer supersaturated with active ingredient and containing the active ingredient in homogeneous dispersion or in solution, characterized in that it is carried out avoiding process parameters which favour or induce crystallization of active ingredient, and any type of pressure operating on the plaster and, in particular, on the active layer is avoided while it is carried out.

Abstract: An active-substance-containing transdermal therapeutic system for the controlled release of estradiol or its pharmaceutically acceptable derivatives alone or combined with gestagens consisting of a backing layer, an active-substance-containing reservoir which is bonded thereto and produced by using pressure sensitive adhesives, and a removable protective layer is characterized by the fact that the pressure sensitive adhesive comprises esters of colophony.

Abstract: An active substance-containing patch for the controlled release of estradiol or its pharmaceutically acceptable derivatives alone or in combination with gestagens from a backing layer, an active substance-containing reservoir connected thereto and produced by using pressure sensitive adhesives and at least one penetration enhancer, and a removable protective layer is characterized by the fact that the penetration enhancer is selected from substances based on carboxylic acids.

Abstract: The invention concerns a transdermal therapeutic system comprising the active substance 17-.beta.-estradiol and optionally further active substances, with a laminated structure comprising a backing layer which is substantially impermeable to moisture and impermeable to active substance, one or more matrix layers and, where non-adhesive matrix layers are present, an adhesive layer, characterized in that the concentration of the dissolved estradiol in all matrix layers and, where an adhesive layer is present, in the adhesive layer lies between its saturation concentration in dry condition und its saturation concentration in moist condition, whereby the term "dry condition" is understood to mean that the base material is in equilibrium with a gas phase with less than 10% relative humidity and the term "moist condition" is understood to mean that the base material is in equilibrium with a gas phase with more than 90% relative humidity.

Abstract: An active substance-containing patch for the controlled release of estradiol or its pharmaceutically acceptable derivatives alone or combined with gestagens, comprising a backing layer, an active substance-containing reservoir which is bonded thereto and produced by using pressure-sensitive adhesives, and a removable protective layer, is characterized by the fact that the pressure-sensitive adhesive comprises ethylcellulose, esters of non-hydrogenated and/or hydrogenated colophony, and lauric acid.

Abstract: An active substance-containing patch for the controlled release of active substances, comprising a backing layer, an adjoining active substance-containing reservoir layer softening at body temperature, a membrane controlling the active substance release, a pressure-sensitive adhesive device permitting fixation of the patch to the skin, and a removable protective layer, is characterized by the fact that the reservoir layer which softens at body temperature is spaced away from the controlling membrane by means of a device made of a material impermeable to the active substance which extends all over the mutually facing surfaces of the reservoir and the membrane and which has at least one passage for the reservoir layer which softens at body temperature.

Abstract: An active substance-containing patch for the controlled release of nitroglycerin to the skin, consisting of an impermeable backing layer, a reservoir attached thereto and comprising pressure-sensitive hot melt adhesive and active substance, and a removable protective layer, in which patch the reservoir comprises in homogeneous mixture:a) tackifying soft and/or hard resins,b) plasticizers,c) nitroglycerin preparation.

Abstract: The invention relates to a dermal plaster for the transdermal provision of nitroglycerin comprising a carrier film and a removable protective film and an adhesive mass containing nitroglycerine on the basis of a cross-linked acrylate-vinyl acetate copolymer in which the monomer mix used for polymerization consists essentially of 21 to 40% wt. vinyl acetate, 55 to 70% wt. of an acrylic acid C2-8 alkyl ester and 3 to 10% wt. of an acrylic acid C2-4 hydroxyalkyl ester and which is cross-linked by heating and the removal of any solvents present after the addition of a cross-linking agent and the nitroglycerin.