Abstract: A tubing set suitable for use in co-operation with a machine for carrying out a hemodialysis treatment of a patient's blood includes a blood out-tube for supplying the blood from the patient to a filter, a blood in-tube for supplying the blood from the filter back to the patient, and a substitution tube connected to the blood in-tube or the blood out-tube suitable for providing a substitution fluid in the patient's blood. The substitution tube includes an insert for the infusion of drugs, with the insert being configured to cooperate with a vial. A method of delivering drugs includes use of the tubing set, including the substitution tube, the insert, and the vial.