Patents by Inventor Reinout Cornelus Andreas Schellekens

Reinout Cornelus Andreas Schellekens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PH-controlled pulsatile delivery system, methods for preparation and use thereof
    Patent number: 11744803
    Abstract: The invention relates to delivery systems that allow for the pulsatile release of a substance, such as a drug, in response to a change in pH. More specifically, it relates to drug administration to the GI tract, in particular to site-specific intestinal drug delivery via the oral route. Provided is a pH-controlled pulsatile release system (PPRS) comprising a core surrounded by a coating layer, wherein said core comprises an active substance and wherein said coating layer comprises a pH-sensitive coating material wherein a swellable agent is embedded. Said swellable agent is capable of taking up at least 1.1 times, preferably at least 5 times, more preferably at least 10 times its weight in water. Also provided is a pharmaceutical composition comprising a PPRS, in particular a colon-specific PPRS.
    Type: Grant
    Filed: July 29, 2005
    Date of Patent: September 5, 2023
    Assignee: Stichting Groningen Centre for Drug Rese
    Inventors: Reinout Cornelus Andreas Schellekens, Henderik Willem Frijlink
  • PH-Controlled Pulsatile Delivery System, Methods for Preparation and Use Thereof
    Publication number: 20090181089
    Abstract: The invention relates to delivery systems that allow for the pulsatile release of a substance, such as a drug, in response to a change in pH. More specifically, it relates to drug administration to the GI tract, in particular to site-specific intestinal drug delivery via the oral route. Provided is a pH-controlled pulsatile release system (PPRS) comprising a core surrounded by a coating layer, wherein said core comprises an active substance and wherein said coating layer comprises a pH-sensitive coating material wherein a swellable agent is embedded. Said swellable agent is capable of taking up at least 1.1 times, preferably at least 5 times, more preferably at least 10 times its weight in water. Also provided is a pharmaceutical composition comprising a PPRS, in particular a colon-specific PPRS.
    Type: Application
    Filed: July 29, 2005
    Publication date: July 16, 2009
    Inventors: Reinout Cornelus Andreas Schellekens, Henderik Willem Frijlink