Patents by Inventor Reka Haraszti

Reka Haraszti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONJUGATED OLIGONUCLEOTIDES
    Publication number: 20240084297
    Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.
    Type: Application
    Filed: February 16, 2023
    Publication date: March 14, 2024
    Inventors: Anastasia KHVOROVA, Mehran NIKAN, Matthew HASSLER, Maire OSBORN, Reka HARASZTI, Andrew COLES, Anton TURANOV, Neil ARONIN, Annabelle BISCANS
  • EXOSOMAL LOADING USING HYDROPHOBICALLY MODIFIED OLIGONUCLEOTIDES
    Publication number: 20230399659
    Abstract: In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobically modified oligonucleotide cargo, and uses thereof, are also provided.
    Type: Application
    Filed: October 18, 2022
    Publication date: December 14, 2023
    Inventors: Anastasia Khvorova, Neil Aronin, Marie Cecile Didiot, Reka Haraszti
  • Conjugated oligonucleotides
    Patent number: 11753638
    Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: September 12, 2023
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Mehran Nikan, Matthew Hassler, Maire Osborn, Reka Haraszti, Andrew Coles, Anton Turanov, Neil Aronin, Annabelle Biscans
  • Exosomal loading using hydrophobically modified oligonucleotides
    Patent number: 11505807
    Abstract: In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobically modified oligonucleotide cargo, and uses thereof, are also provided.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: November 22, 2022
    Assignee: University of Massachusetts
    Inventors: Anastasia Khvorova, Neil Aronin, Marie Cecile Didiot, Reka Haraszti
  • BIOACTIVE CONJUGATES FOR OLIGONUCLEOTIDE DELIVERY
    Publication number: 20200339983
    Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
    Type: Application
    Filed: March 9, 2020
    Publication date: October 29, 2020
    Inventors: Anastasia Khvorova, Mehran Nikan, Matthew Hassler, Maire Osborn, Reka Haraszti, Andrew Coles, Anton Turanov, Neil Aronin
  • EXOSOMAL LOADING USING HYDROPHOBICALLY MODIFIED OLIGONUCLEOTIDES
    Publication number: 20200283801
    Abstract: In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobically modified oligonucleotide cargo, and uses thereof, are also provided.
    Type: Application
    Filed: December 13, 2019
    Publication date: September 10, 2020
    Inventors: Anastasia Khvorova, Neil Aronin, Marie Cecile Didiot, Reka Haraszti
  • Bioactive conjugates for oligonucleotide delivery
    Patent number: 10633653
    Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: April 28, 2020
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Mehran Nikan, Matthew Hassler, Maire Osborn, Reka Haraszti, Andrew Coles, Anton Turanov, Neil Aronin
  • Exosomal loading using hydrophobically modified oligonucleotides
    Patent number: 10513710
    Abstract: In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobic ally modified oligonucleotide cargo, and uses thereof, are also provided.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: December 24, 2019
    Assignee: University of Massachusetts
    Inventors: Anastasia Khvorova, Neil Aronin, Marie Cecile Didiot, Reka Haraszti
  • CONJUGATED OLIGONUCLEOTIDES
    Publication number: 20190185855
    Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.
    Type: Application
    Filed: August 11, 2017
    Publication date: June 20, 2019
    Inventors: Anastasia KHVOROVA, Mehran NIKAN, Matthew HASSLER, Maire OSBORN, Reka HARASZTI, Andrew COLES, Anton TURANOV, Neil ARONIN, Annabelle BISCANS
  • BIOACTIVE CONJUGATES FOR OLIGONUCLEOTIDE DELIVERY
    Publication number: 20170043024
    Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
    Type: Application
    Filed: August 12, 2016
    Publication date: February 16, 2017
    Inventors: Anastasia Khvorova, Mehran Nikan, Matthew Hassler, Maire Osborn, Reka Haraszti, Andrew Coles, Anton Turanov, Neil Aronin