Patents by Inventor Rembert Pieper

Rembert Pieper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metaproteomic Method to Identify Secreted Pattern Recognition Molecules and Adhesive Antimicrobial Factors for Detection of Microbial Agents Eliciting Inflammation in the Human Host
    Publication number: 20140243220
    Abstract: Described herein are methods for analyzing complex host-microbial mixtures. The disclosed methods may be used to diagnosis or prognose in a subject an inflammatory disease, which is caused by or contributed to by microbes.
    Type: Application
    Filed: February 25, 2014
    Publication date: August 28, 2014
    Applicant: J. Craig Venter Institute
    Inventor: Rembert Pieper
  • Immunosubtraction method
    Patent number: 7691645
    Abstract: Removal of abundant proteins from a sample enhances detection and resolution of less abundant proteins in the sample such as in two-dimensional gel electrophoresis. The removal is accomplished by immunosubtraction of several high abundance, interfering or contaminating proteins simultaneously.
    Type: Grant
    Filed: October 16, 2001
    Date of Patent: April 6, 2010
    Assignee: Agilent Technologies, Inc.
    Inventors: N. Leigh Anderson, Rembert Pieper
  • Immunosubtraction method
    Patent number: 7642089
    Abstract: Removal of abundant proteins from a sample enhances detection and resolution of less abundant proteins in the sample such as in two-dimensional gel electrophoresis. The removal is accomplished by immunosubtraction of several high abundance, interfering or contaminating proteins simultaneously.
    Type: Grant
    Filed: January 9, 2002
    Date of Patent: January 5, 2010
    Assignee: Agilent Technologies, Inc.
    Inventors: Rembert Pieper, N. Leigh Anderson
  • Modified modular polyketide synthase
    Patent number: 7101684
    Abstract: Modular polyketide synthases modified so as not to incorporate natural starter units can be used for clean synthesis of novel polyketides.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: September 5, 2006
    Assignees: Stanford University, Brown University Research Foundation
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David Cane
  • Cell-free synthesis of polyketides
    Publication number: 20040203119
    Abstract: Cell-free systems which effect the production of polyketides employing modular polyketide synthases are described. Libraries of new and/or known polyketides may also be produced in cell-free systems employing aromatic PKS, modular PKS or both.
    Type: Application
    Filed: February 27, 2004
    Publication date: October 14, 2004
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane
  • Immunosubtraction method for sample preparation for 2-dge
    Publication number: 20040115725
    Abstract: Removal of abundant proteins from a sample enhances detection and resolution of less abundant proteins in the sample such as in two-dimensional gel electrophoresis. The removal is accomplished by immunosubtraction of several high abundance, interfering or contaminating proteins simultaneously.
    Type: Application
    Filed: January 13, 2004
    Publication date: June 17, 2004
    Inventors: Rembert Pieper, N. Leigh Anderson
  • Cell-free synthesis of polyketides
    Patent number: 6750040
    Abstract: Cell-free systems which effect the production of polyketides employing modular polyketide synthases are described. Libraries of new and/or known polyketides may also be produced in cell-free systems employing aromatic PKS, modular PKS or both.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: June 15, 2004
    Assignees: Board of Trustees of the Leland Stanford Junior University, Brown University Research Foundation
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane
  • Method to produce novel polyketides
    Patent number: 6710189
    Abstract: A polyketide, or an antibiotic which is obtainable from the polyketide by a method comprising treating the polyketide with a culture medium conditioned by Saccharopolyspora erythraea, selected from the group consisting of:
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: March 23, 2004
    Assignees: Stanford University, Brown University
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane, Camilla Kao, Gary Ashley
  • Cell-free synthesis of polyketides
    Patent number: 6531299
    Abstract: Cell-free systems which effect the production of polyketides employing modular polyketide synthases are described. Libraries of new and/or known polyketides may also be produced in cell-free systems employing aromatic PKS, modular PKS or both.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: March 11, 2003
    Assignees: Stanford University, Brown University Research Foundation
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane
  • Method to produce novel polyketides
    Publication number: 20030044938
    Abstract: Modified PKS gene clusters which produce novel polyketides in an efficient system in a host cell or in a cell free extract are described.
    Type: Application
    Filed: June 28, 2002
    Publication date: March 6, 2003
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane, Camilla Kao, Gary Ashley
  • Quantification of low molecular weight and low abundance proteins using high resolution two-dimensional electrophoresis and mass spectrometry
    Publication number: 20030032017
    Abstract: Methods are disclosed comprising specific technologies including a system for routinely concentrating proteins from human urine ranging down to approximately 2.5 kDa automated systems for immunosubtraction of major proteins form urine and plasma to reveal minor ones, and systems for routinely fractionating protein mixtures on the basis of native molecular weight, isoelectric point that are applicable to a range of human body fluid proteins, particularly those found in urine.
    Type: Application
    Filed: August 3, 2001
    Publication date: February 13, 2003
    Applicant: Large Scale Proteomics, Corp.
    Inventors: Norman G. Anderson, Madhu Mondal, Rembert Pieper
  • Method to produce novel polyketides
    Patent number: 6500960
    Abstract: Modified PKS gene clusters which produce novel polyketides in an efficient system in a host cell or in a cell free extract are described. The novel polyketides result from the incorporation of diketides of the formula wherein A is a moiety that activates the diketide, and at least one of R1 and R2 is a substituent other than that natively occurring in the diketide normally processed by the modified PKS cluster. The polyketides may also be glycosylated to provide antibiotics.
    Type: Grant
    Filed: May 14, 1999
    Date of Patent: December 31, 2002
    Assignees: Stanford University (Board of Trustees of the Leland Stanford Junior University), Brown University Research Foundation
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane, Camilla Kao
  • Immunosubtraction method for sample preparation for 2-DGE
    Publication number: 20020127739
    Abstract: Removal of abundant proteins from a sample enhances detection and resolution of less abundant proteins in the sample such as in two-dimensional gel electrophoresis. The removal is accomplished by immunosubtraction of several high abundance, interfering or contaminating proteins simultaneously.
    Type: Application
    Filed: October 16, 2001
    Publication date: September 12, 2002
    Inventors: Rembert Pieper, N. Leigh Anderson
  • Non-genetic based protein disease markers
    Publication number: 20020072492
    Abstract: Protein disease markers for obesity, osteoporosis, diabetes, osteoarthritis and hypertension are disclosed. These markers are not inherited or of genetic origin as they were not found in identical twins of the affected individual. Methods and uses for diagnostic, therapeutic and drug discovery are disclosed.
    Type: Application
    Filed: June 22, 2001
    Publication date: June 13, 2002
    Inventors: Timothy G. Myers, Rembert Pieper, John Taylor, Sandra Steiner, N. Leigh Anderson
  • Method to produce novel polyketides
    Publication number: 20010024811
    Abstract: Modified PKS gene clusters which produce novel polyketides in an efficient system in a host cell or in a cell free extract are described.
    Type: Application
    Filed: May 29, 2001
    Publication date: September 27, 2001
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Crane, Camilla Kao
  • Cell-free synthesis of polyketides
    Patent number: 6274560
    Abstract: Cell-free systems which effect the production of polyketides employing modular polyketide synthases are described. Libraries of new and/or known polyketides may also be produced in cell-free systems employing aromatic PKS, modular PKS or both.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: August 14, 2001
    Assignees: Brown University Research Foundation, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane, Camilla Kao
  • Method to produce novel polyketides
    Patent number: 6261816
    Abstract: Modified PKS gene clusters which produce novel polyketides in an efficient system in a host cell or in a cell free extract are described.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: July 17, 2001
    Assignees: Stanford University, Brown University Research Foundation
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane, Camilla Kao
  • Synthesis of polyketides from diketides
    Patent number: 6080555
    Abstract: Cell-free systems which effect the production of polyketides employing modular polyketide synthases are described. Libraries of new and/or known polyketides may also be produced in cell-free systems employing aromatic PKS, modular PKS or both.
    Type: Grant
    Filed: July 5, 1996
    Date of Patent: June 27, 2000
    Assignees: Stanford University, Brown University
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane
  • Method to produce novel polyketides
    Patent number: 6066721
    Abstract: Modified PKS gene clusters which produce novel polyketides in an efficient system in a host cell or in a cell free extract are described.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: May 23, 2000
    Assignees: Stanford University, Brown University Research Foundation
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane, Camilla Kao