Patents by Inventor Remi Lemaire

Remi Lemaire has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of conjugates with linkers cleavable by photodissociation or fragmentation for mass spectrometry analysis of tissue sections
    Patent number: 8221972
    Abstract: The invention concerns a method for determining at least one target molecule map in a tissue section, using at least one (A-X)n-B conjugate, wherein A is a tag molecule of known molecular weight, X is a linker that is cleaved during sample desorption/ionization, n is an integer of at least 1, and B is a binding molecule that binds specifically to said target molecule. When using MALDI mass spectrometry, said linker molecule X may be cleaved by photodissociation during sample laser irradiation if photocleavable at the wavelength of said MALDI laser. Alternatively, when using UV-MALDI, IR-MALDI, SIMS or DESI mass spectrometry, said linker molecule X may be cleaved by fragmentation during sample desorption/ionization.
    Type: Grant
    Filed: June 7, 2006
    Date of Patent: July 17, 2012
    Assignees: Centre National de la Recherche Scientifique (CNRS), Universite des Sciences et Technologies de Lille, Eurogentec S.A.
    Inventors: Rémi Lemaire, Isabelle Fournier, Michel Salzet, Michel Dechamps, Jean-Claude Edmond Tabet, Gottfried Proess, Ivo Rudloff, Marc Lemaitre
  • Use of ionic matrices for maldi mass spectrometry analysis of tissue sections
    Patent number: 8148676
    Abstract: The invention concerns improved methods for studying peptides/proteins expression in a tissue section or for determining at least one compound, in particular a protein, expression map in a tissue section, using ionic MALDI matrices.
    Type: Grant
    Filed: June 7, 2006
    Date of Patent: April 3, 2012
    Assignees: Centre National de la Recherche Scientifique (CNRS), Universite des Sciences et Technologies de Lille
    Inventors: Rémi LeMaire, Isabelle Fournier, Michel Salzet, Jean-Claude Edmond Tabet
  • Use of Conjugates with linkers cleavable by photodissociation or fragmentation for mass spectromety analysis of tissue sections
    Publication number: 20110151451
    Abstract: The invention concerns a method for determining at least one target molecule map in a tissue section, using at east one (A-X)n-B conjugate, wherein A is a tag molecule of known molecular weight, X is a linker that is cleaved during sample desorption/ionization, n is an integer of at least 1, and B is a binding molecule that binds specifically to said target molecule. When using MALDI mass spectrometry, said linker molecule X may be cleaved by photodissociation during sample laser irradiation if photocleavable at the wavelength of said MALDI laser. Alternatively, when using UV-MALDI, IR-MALDI, SIMS or DESI mass spectrometry, said linker molecule X may be cleaved by fragmentation during sample desorption/ionization.
    Type: Application
    Filed: June 7, 2006
    Publication date: June 23, 2011
    Inventors: Remi Lemaire, Isabelle Fournier, Michel Salzet, Michel Deschamps, Jean-Claude Edmond Tabet, Gottfried Proess, Ivo Rudloff, Marc Lemaitre
  • Use of Ionic Matrices For Maldi Mass Spectrometry Analysis of Tissue Sections
    Publication number: 20080203289
    Abstract: The invention concerns improved methods for studying peptides/proteins expression in a tissue section or for determining at least one compound, in particular a protein, expression map in a tissue section, using ionic MALDI matrices.
    Type: Application
    Filed: June 7, 2006
    Publication date: August 28, 2008
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DES SCIENCES ET TECHNOLOGIES DE LILLE
    Inventors: Remi Lemaire, Isabelle Fournier, Michel Salzet, Jean-Claude Edmond Tabet