Patents by Inventor Remo Anton Hochstrasser

Remo Anton Hochstrasser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9797891
    Abstract: A method for determining a biological response of a target (41, 42) to a soluble candidate substance includes the steps: introducing a soluble candidate substance into a laminar flow of a buffer liquid (2) to form a candidate substance solute (3) having an initial concentration profile (31); dispersing the initial concentration profile (31) to form a dispersed concentration profile (32); directing the dispersed concentration profile (32) into a detection channel (12) to form a final symmetrical concentration profile (33) therein; introducing a target into the detection channel (12) to obtain a combined concentration profile including a constant target concentration profile overlying the final symmetrical concentration profile (33); holding in the detection channel (12) at least one half of the combined concentration profile; and optically scanning the combined concentration profile to detect an optical signal representative of the biological response of the target to the soluble candidate substance.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: October 24, 2017
    Assignee: F. Hoffmann-La Roche AG
    Inventors: Michael Werner, Rainer E. Martin, Remo Anton Hochstrasser
  • Publication number: 20160011180
    Abstract: A method for determining a biological response of a target (41, 42) to a soluble candidate substance comprises the steps: introducing a soluble candidate substance into a laminar flow of a buffer liquid (2) to form a candidate substance solute (3) having an initial concentration profile (31); dispersing the initial concentration profile (31) to form a dispersed concentration profile (32); directing the dispersed concentration profile (32) into a detection channel (12) to form a final symmetrical concentration profile (33) therein; introducing a target into the detection channel (12) to obtain a combined concentration profile comprising a constant target concentration profile overlying the final symmetrical concentration profile (33); holding in the detection channel (12) at least one half of the combined concentration profile; and optically scanning the combined concentration profile to detect an optical signal representative of the biological response of the target to the soluble candidate substance.
    Type: Application
    Filed: March 4, 2014
    Publication date: January 14, 2016
    Inventors: Michael Werner, Rainer E. Martin, Remo Anton Hochstrasser
  • Patent number: 9201084
    Abstract: A robotic microplate storage system includes a freezer room having freezing units and a first robot for moving and removing microplates into and out of the freezing unit. The first robot can also transfer microplates to a processing station, where the microplates are stored in a microplate recipient within the freezing unit. The storage system may also include at least one processing room which is thermally separated from the freezer room. Each processing room may include a processing station having a tube transfer module and a second robot for moving the microplates between the microplate recipients and the tube transfer module. The first robot may be designed such that it is only capable of removing a microplate recipient from and moving it into a freezing unit as well as transferring it from a freezing unit to a processing station or vice versa.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: December 1, 2015
    Assignee: F. HOFFMAN-LA ROCHE AG
    Inventors: Christof Fattinger, Remo Anton Hochstrasser, Dieter Voegelin, Thomas Zumstein
  • Patent number: 7867452
    Abstract: A multi-well filtration device for filtering a suspension comprises a filtration plate with a filtration chamber and a collecting plate with a collecting well. The filtration chamber is connected to the collecting well and a filter element is arranged between the filtration chamber and the collecting well. A separation layer is arranged between the filtration plate and the collecting plate adjacent to the filter element. The use such of a separation layer allows an easy detachment of the filtration plate from the collecting plate. The detached filtration plate can comfortably be transferred into an analysis device, in which the solid phase of the filtration chamber can separately be analyzed through the separation layer, without any replacement of the solid phase.
    Type: Grant
    Filed: May 9, 2007
    Date of Patent: January 11, 2011
    Assignee: F. Hoffmann-La Roche AG
    Inventors: Remo Anton Hochstrasser, Dieter Voegelin, Urs Schwitter, Pirmin Hidber
  • Patent number: 7857575
    Abstract: A stacker (1) for storing a plurality of microplates each having a top surface side and a bottom surface side opposed to the top surface side, comprises a housing and a removal gate (13) for removing a microplate of the plurality of microplates out of the housing. The stacker (1) is arranged to accommodate the plurality of microplates inside the housing such that the top surface side of one microplate of the plurality of microplates abuts on the bottom surface side of an adjacent microplate of the plurality of microplates and such that the housing adjoins to the plurality of microplates. Using such a stacker 1, the plurality of microplates can be arranged and stored in a compact manner wherein the single microplates of the plurality of microplates can still selectively and efficiently be accessed.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: December 28, 2010
    Assignee: F. Hoffmann-LaRoche AG
    Inventors: Christoph Fattinger, Thomas Zumstein, Remo Anton Hochstrasser, Dieter Voegelin
  • Publication number: 20100086440
    Abstract: In some embodiments of the present disclosure, a robotic storage system for storing microplates carrying a plurality of sample tubes is provided and may comprise a freezer room having a plurality of freezing units and a first robot being capable of removing a microplate from and moving a microplate into a freezing unit. The first robot may be further capable of transferring the microplate to a processing station, where the microplates are stored in the freezing units such that a plurality of microplates are arranged one above the other in a microplate recipient. The robotic storage system may also include at least one processing room and means for thermally separating the processing room from the freezer room. Each processing room may include a processing station having at least one tube transfer module as well as a second robot for moving the microplates between the microplate recipients and the at least one tube transfer module.
    Type: Application
    Filed: September 30, 2009
    Publication date: April 8, 2010
    Applicant: F. Hoffmann-La Roche AG
    Inventors: Christof Fattinger, Remo Anton Hochstrasser, Dieter Voegelin, Thomas Zumstein
  • Publication number: 20100005826
    Abstract: A convection barrier for a freezer is disclosed. The convection barrier may include a foil having at least one opening therein, storage and transport means for storing and moving the foil so as to transport the at least one opening to a desired position allowing access through the at least one opening to the interior of the freezer at the desired position and tensioning means for continuously keeping the foil in a tensioned state.
    Type: Application
    Filed: July 8, 2009
    Publication date: January 14, 2010
    Applicant: F. HOFFMANN-LA ROCHE AG
    Inventors: Thomas Zumstein, Christof Fattinger, Remo Anton Hochstrasser
  • Patent number: 7645369
    Abstract: A separation device and a separation method for biomolecular sample material and in particular protein mixtures. For this purpose a separation element 10 for the two-dimensional and preferable electrophoretic separation of components of the sample material is provided in area 30 of a separation plane. According to the invention it is proposed that the separation element 10 has a channel or transfer structure 14 for the locally resolved discharge of separated sample components in a transport direction that is at right angles to the separation plane onto a support surface 16 that is preferably suitable for mass spectroscopic analyses.
    Type: Grant
    Filed: May 2, 2005
    Date of Patent: January 12, 2010
    Assignee: Roche Diagnositcs Operations, Inc.
    Inventors: Hans-Joachim Hoeltke, Albert Roeder, Alois Rainer, Peter Berndt, Carlo Effenhauser, Hanno Langen, Remo Anton Hochstrasser
  • Publication number: 20080260511
    Abstract: A stacker (1) for storing a plurality of microplates each having a top surface side and a bottom surface side opposed to the top surface side, comprises a housing and a removal gate (13) for removing a microplate of the plurality of microplates out of the housing. The stacker (1) is arranged to accommodate the plurality of microplates inside the housing such that the top surface side of one microplate of the plurality of microplates abuts on the bottom surface side of an adjacent microplate of the plurality of microplates and such that the housing adjoins to the plurality of microplates. Using such a stacker 1, the plurality of microplates can be arranged and stored in a compact manner wherein the single microplates of the plurality of microplates can still selectively and efficiently be accessed.
    Type: Application
    Filed: March 27, 2008
    Publication date: October 23, 2008
    Applicant: F. Hoffmann-La Roche AG
    Inventors: Christoph Fattinger, Thomas Zumstein, Remo Anton Hochstrasser, Dieter Voegelin
  • Patent number: 7438861
    Abstract: A heatable pipette, with a needle has an inner channel defined by an inner wall, arranged to conduct electric current through the inner wall for resistively heating the inner wall. The needle has an outer wall, which is defined between the outer wall and the inner wall and connectable for providing pressure air into the outer channel. By conducting current directly through the inner wall, the inner wall itself operates as resistor. Particularly, if the inner wall is made of an appropriate material, for example of stainless steel, the ohmic resistance of the inner wall is not negligible even if the inner wall is very thin. Therefore, the inner wall can directly be used as resistor for resistance heating of the inner wall even if the needle is manufactured in small dimensions.
    Type: Grant
    Filed: May 16, 2007
    Date of Patent: October 21, 2008
    Assignee: F. Hoffmann-La Roche AG
    Inventors: Remo Anton Hochstrasser, Dieter Voegelin, Frédéric Ran
  • Patent number: 7409041
    Abstract: Methods for transmission mode X-ray diffraction analysis of a sample by means of apparatuses comprising an X-ray radiation source that provides X-ray radiation for irradiating the sample and a detector for detecting X-ray radiation transmitted through and diffracted by the sample. The methods include: (a) placing a sample to be analyzed on a substrate, (b) generating X-ray radiation by means of an X-ray radiation source, (c) positioning the substrate and the sample in an initial position, (d) rotating the substrate and the sample with respect to the initial position around a rotation axis over a predetermined rotation angle, (e) tilting the substrate and the sample with respect to the initial position around a tilting axis over a tilting angle, (f) detecting with a detector the X-ray radiation transmitted through and diffracted by the sample during a time interval, and (g) analyzing the X-ray radiation that is detected.
    Type: Grant
    Filed: May 2, 2006
    Date of Patent: August 5, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Olaf Grassmann, Michael Hennig, Remo Anton Hochstrasser, Urs Schwitter
  • Publication number: 20070297950
    Abstract: An equilibration device for equilibrating a comparably economic equilibration of a fluid. A first sealing layer is adjacent to the surface side between the plate and the cover. A second sealing layer is arrangeable adjacent to the cover between the plate and the cover and a tube with an open end, which is inside the well such that the open end of the tube projects above the opening of the well. The use of two sealing layers in the equilibration device allows combining the advantages of a material of the first sealing layer, e.g. high flexibility to seal uneven areas and to compensate the step formed by the tube projecting above the opening of the well, as well as the advantages of the second sealing layer, e.g. inexpensiveness, can come to combined effect when the two sealing layers are arranged appropriately.
    Type: Application
    Filed: June 14, 2007
    Publication date: December 27, 2007
    Applicant: F. Hoffmann-La Roche AG
    Inventors: Remo Anton Hochstrasser, Dieter Voegelin, Urs Schwitter, Pirmin Hidber
  • Publication number: 20070274870
    Abstract: A heatable pipette, with a needle has an inner channel defined by an inner wall, arranged to conduct electric current through the inner wall for resistively heating the inner wall. The needle has an outer wall, which is defined between the outer wall and the inner wall and connectable for providing pressure air into the outer channel. By conducting current directly through the inner wall, the inner wall itself operates as resistor. Particularly, if the inner wall is made of an appropriate material, for example of stainless steel, the ohmic resistance of the inner wall is not negligible even if the inner wall is very thin. Therefore, the inner wall can directly be used as resistor for resistance heating of the inner wall even if the needle is manufactured in small dimensions.
    Type: Application
    Filed: May 16, 2007
    Publication date: November 29, 2007
    Applicant: F. Hoffmann-La Roche AG
    Inventors: Remo Anton Hochstrasser, Dieter Voegelin, Frederic Ran
  • Publication number: 20070264164
    Abstract: A Multi-well plate for mixing a fluid, comprises a plurality of wells. Each of the wells has an opening arranged at a top side of the multi-well plate. At least one of the wells has a cross-section parallel to the top side having an elongated shape. The multi-well plate comprises 384 wells arranged in 16 rows and 24 columns or 96 wells arranged in 8 rows and 12 columns. By means of such a multi-well plate a faster and therefore more efficient mixing is possible using standard mixing devices such as shakers.
    Type: Application
    Filed: May 9, 2007
    Publication date: November 15, 2007
    Applicant: F. Hoffmann-La Roche AG
    Inventors: Remo Anton Hochstrasser, Dieter Voegelin
  • Publication number: 20070264163
    Abstract: A multi-well filtration device for filtering a suspension comprises a filtration plate with a filtration chamber and a collecting plate with a collecting well. The filtration chamber is connected to the collecting well and a filter element is arranged between the filtration chamber and the collecting well. A separation layer is arranged between the filtration plate and the collecting plate adjacent to the filter element. The use such of a separation layer allows an easy detachment of the filtration plate from the collecting plate. The detached filtration plate can comfortably be transferred into an analysis device, in which the solid phase of the filtration chamber can separately be analyzed through the separation layer, without any replacement of the solid phase.
    Type: Application
    Filed: May 9, 2007
    Publication date: November 15, 2007
    Applicant: F. Hoffmann-La Roche AG
    Inventors: Remo Anton Hochstrasser, Dieter Voegelin, Urs Schwitter, Pirmin Hidber
  • Publication number: 20030209091
    Abstract: Method and apparatus for transporting a plurality of test tubes (11) in a measuring system, the test tubes being carried by a test tube carrier (21) which comprises a plurality of compartments (22), each of which is adapted for receiving and holding a test tube.
    Type: Application
    Filed: May 9, 2003
    Publication date: November 13, 2003
    Inventors: Christof Fattinger, Remo Anton Hochstrasser, Hansjorg Tschirky
  • Patent number: D562463
    Type: Grant
    Filed: May 3, 2005
    Date of Patent: February 19, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Peter Berndt, Christof Fattinger, Remo Anton Hochstrasser, Tom Kissling