Patents by Inventor Remo Bottega

Remo Bottega has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cationic amphiphiles of cholesterol
    Patent number: 6627218
    Abstract: A stable aqueous dispersion which comprises a cationic lipid which is a molecule which comprises a cholesterol-derived lipophilic group, a linker bond which is hydrolyzable by cellular enzymes and relatively resistant to base-catalyzed hydrolysis, a spacer arm and a cationic amino group, and an appropriate co-lipid. The invention also includes the cationic lipids and mammalian plasmid DNA or other cells in admixture with the aqueous dispersion.
    Type: Grant
    Filed: August 22, 2002
    Date of Patent: September 30, 2003
    Assignees: The University of Tennessee Research Foundation, McMaster University
    Inventors: Leaf Huang, Richard M. Epand, Remo Bottega
  • Cationic amphiphiles
    Patent number: 6509032
    Abstract: A cationic lipid useful in transfection of cells with DNA is disclosed.
    Type: Grant
    Filed: February 2, 1995
    Date of Patent: January 21, 2003
    Assignee: McMaster University
    Inventors: Leaf Huang, Richard M. Epand, Remo Bottega
  • Cationic amphiphiles of cholesterol
    Publication number: 20030012813
    Abstract: A stable aqueous dispersion which comprises a cationic lipid which is a molecule which comprises a cholesterol-derived lipophilic group, a linker bond which is hydrolyzable by cellular enzymes and relatively resistant to base-catalyzed hydrolysis, a spacer arm and a cationic amino group, and an appropriate co-lipid. The invention also includes the cationic lipids and mammalian plasmid DNA or other cells in admixture with the aqueous dispersion.
    Type: Application
    Filed: August 22, 2002
    Publication date: January 16, 2003
    Applicant: University of Tennessee Research Company
    Inventors: Leaf Huang, Richard M. Epand, Remo Bottega
  • Cationic amphiphiles of cholesterol
    Publication number: 20020114828
    Abstract: A stable aqueous dispersion which comprises a cationic lipid which is a molecule which comprises a cholesterol-derived lipophilic group, a linker bond which is hydrolyzable by cellular enzymes and relatively resistant to base-catalyzed hydrolysis, a spacer arm and a cationic amino group, and an appropriate co-lipid. The invention also includes the cationic lipids and mammalian plasmid DNA or other cells in admixture with the aqueous dispersion.
    Type: Application
    Filed: November 20, 2001
    Publication date: August 22, 2002
    Applicant: University of Tennessee Research Company
    Inventors: Leaf Huang, Richard M. Epand, Remo Bottega
  • Stable aqueous dispersions including cationic lipids
    Patent number: 6361791
    Abstract: A stable aqueous dispersion which comprises a cationic lipid which is a molecule which comprises a cholesterol-derived lipophilic group, a linker bond which is hydrolyzable by cellular enzymes and relatively resistant to base-catalyzed hydrolysis, a spacer arm and a cationic amino group, and an appropriate co-lipid. The invention also includes the cationic lipids and mammalian plasmid DNA or other cells in admixture with the aqueous dispersion.
    Type: Grant
    Filed: December 28, 1995
    Date of Patent: March 26, 2002
    Assignee: The University of Tennessee Research Corporation
    Inventors: Leaf Huang, Richard M. Epand, Remo Bottega
  • Acid salts of cholesterol
    Patent number: 6319516
    Abstract: A stable aqueous dispersion which comprises a cationic lipid which is a molecule which comprises a cholesterol-derived lipophilic group, a linker bond which is hydrolyzable by cellular enzymes and relatively resistant to base-catalyzed hydrolysis, a spacer arm and a cationic amino group, and an appropriate co-lipid. The invention also includes the cationic lipids and mammalian plasmid DNA or other cells in admixture with the aqueous dispersion.
    Type: Grant
    Filed: June 16, 1999
    Date of Patent: November 20, 2001
    Assignees: The University of Tennessee Research Corporation, McMaster University
    Inventors: Leaf Huang, Richard M. Epand, Remo Bottega
  • Method for delivering nucleic acids into cells
    Patent number: 5283185
    Abstract: A method for facilitating the transfer of nucleic acids into cells comprising preparing a mixed lipid dispersion of a cationic lipid with a co-lipid in a suitable carrier solvent. The lipid has a structure which includes a lipophilic group derived from cholesterol, a linker bond, a spacer arm including from about 1 to about 20 carbon atoms in a branched or unbranched linear alkyl chain, and a cationic amino group selected from the group consisting of primary, secondary, tertiary and quaternary amino groups. The method further comprises adding the nucleic acids to the dispersion to form a complex. The cells are then treated with the complex. There is also disclosed a novel cationic amphiphile useful for this purpose.
    Type: Grant
    Filed: August 28, 1991
    Date of Patent: February 1, 1994
    Assignees: University of Tennessee Research Corporation, McMaster University
    Inventors: Richard M. Epand, Remo Bottega, Leaf Huang