Abstract: A medicament delivery device, which comprises a driving mechanism and a housing (1) having a reservoir (2), which is at least partly filled with a substance and which is sealed at least on one side with a flexible wall (21). The driving mechanism is adapted to press a piston (23) against the flexible wall (21) thereby releasing the substance from the reservoir (2) through an opening (25) in the reservoir (2). This provides for a safe and reliable medicament delivery device.

Abstract: An ingestible capsule (10) is provided for delivery of a drug, the capsule (10) comprises a first module (11) and a second module (12). The first module (11) has at least one drug compartment (13) for comprising an amount of the drug. The drug compartment (13) is sealed by a foil (14) with an embedded conducting heating wire (15). The second (12) module comprises electronics (18) for providing an electrical pulse to the heating wire (15) in order to open the drug compartment (13) by melting the foil (14). The first module (11) and second module (12) comprise interoperable connection means (19) for securing the first module (11) to the second module (12) such that the heating wire (15) is electronically coupled to the electronics (18).

Abstract: An ingestible electronic capsule (100) for introduction into the bodily lumen comprises a circuit board with at least one electronic component (4, 5, 7, 8, 9, 11, 12, 13, 14). The circuit board is formed from a flex foil (10), thereby reducing the number of components and improving the robustness and reliability of the ingestible electronic capsule (100).

Abstract: A medicine reservoir (10) is provided for use with a drug delivery device (50). The medicine reservoir (10) is arranged for comprising a drug (13) and comprises a dispensing hole (15) for dispensing the drug (13) into an environment of the drug delivery device (50). The medicine reservoir (10) further comprises a deformable plug (14) which plug (14) is removable by pressure caused by a dispensing action of the drug delivery device (50).

Abstract: An electroholographic display system (800, 900) for displaying a holographic image, includes a coherent light source (830, 930) producing a coherent, collimated, light beam; a spatial light modulator (SLM) (820, 920) adapted to receive and spatially modulate the coherent, collimated, light beam to produce therefrom a spatially modulated light beam including first portions having a first polarization and second portions having a second polarization orthogonal to the first polarization; and a processor and driver unit (810, 910) adapted to generate hologram data representing a holographic image and to apply appropriate voltages to the pixels of the SLM to cause the SLM to modulate the coherent collimated light beam with the hologram data. The spatially modulated light beam is projected to an image plane to produce the holographic image including the first portions having the first polarization and the second portions having a second polarization orthogonal to the first polarization.

Abstract: In magnetic resonance imaging (MRI), selected magnetic dipoles in a subject are aligned with a main magnetic field for later manipulation, and signals received after such manipulations are used to create image representations of the subject. One drawback is that even powerful magnetic fields can only align a very small percentage of dipoles in the region of the field. Electromagnetic radiation endowed with orbital angular momentum (OAM) aligns dipoles along the direction of travel of the radiation, but at a much higher percentage; as high as 100% of the dipoles in the region can be aligned. Resultantly, resonance signals emanating from the region are several orders of magnitude stronger than signals emanated using traditional MRI techniques. All electromagnetic radiation, including visible light can be endowed with OAM and used to hyperpolarize a region of interest.

Abstract: An imaging method uses a plurality of sets of carbon nanotubes. Within a set the carbon nanotubes carry markers for a respective receptor that is specific for the set and the carbon nanotubes have a geometry, characterized for example by a chiral number that gives rise to an electromagnetic absorption peak at a wavelength specific to the set. An image is formed by transmitting electromagnetic radiation to a body, substantially at the wavelengths of the absorption peaks of the sets, e.g. time multiplexed with each other, and detecting for example an ultrasound response to absorption of the transmitted electromagnetic radiation. Different images of the electromagnetic absorption as a function of position in the body are formed for different wavelengths.

Abstract: A magnetic resonance spectroscopy assembly includes a magnet to generate a steady magnetic field, an RF transmit/receive antenna to transmit an RF excitation field into an examination region and acquire magnetic resonance signals from the examination region and a magnetic resonance spectrometer coupled to the RF transmit/receive antenna to collect magnetic resonance spectroscopy data from the magnetic resonance signals. An interventional instrument is provided with the assembly. The interventional instruments carries an optical module to generate photonic radiation endowed with orbital optical momentum (OAM).

Abstract: An image guided radiation therapy system comprises a radiation source to generate radiation. Radiation optics forms a therapeutic radiation beam from the therapeutic radiation from the radiation source. An imaging system forms an image of a target zone to control the radiation optics to direct the therapeutic radiation beam onto the target zone. The radiation optics is provided with an optics module configured to generate an imaging photonic beam endowed with optical angular momentum. The imaging system comprises a magnetic resonance assembly to receive magnetic resonance signals the from the target zone generated by imaging photonic beam endowed with optical angular momentum.

Abstract: A magnetic resonance examination system comprises an RF-system for inducing resonance in polarized dipoles and receiving magnetic resonance signals from an object to be examined. A thermometry module dervies a temperature distribution of the object to be examined from the magnetic resonance signals. The magnetic resonance examination system further comprises a photonic-based hyperpolarization device with a photonic source for emitting electromagnetic radiation, a moder converter, such as a phase hologram to impart orbital angular momentum to the electromagnetic radiation and via spatial filter to select from the phase hologram a diffracted photonic beam endowed with orbital angular momentum for polarizing the dipoles via transferred orbital angular momentum.

Abstract: One or more light beam endowed with photonic orbital angular momentum generating devices are mounted at preselected locations on an insertable instrument to hyperpolarize nuclear magnetic dipoles in a region of interest. The hyperpolarized nuclear magnetic dipoles are caused to resonate, generating magnetic resonance signals. A controller controls gradient coils to induce a magnetic field gradient across the region of interest, such that the frequency of the resonance signals is indicative of spatial positions. A frequency-to-position decoder converts the resonance signal frequencies into spatial positions. A video processor combines the spatial positions and a portion of a diagnostic image from a diagnostic image memory into a combined image which depicts the location of the region of interest or a portion of the instrument marked on the diagnostic image and displays the combined image on a monitor.

Abstract: A device capable of producing a high resolution chemical analysis of a sample, such as fluid, is based upon nuclear magnetic resonance (NMR) spectroscopy. The nuclear magnetic polarizations of the sample are generated by sequentially illuminating the sample with a focused beam of light carrying angular orbital angular momentum (OAM) and possibly momentum (spin). Unlike in a typical NMR used for magnetic nuclear resonance imaging (MRI) or spectroscopy, the present device does not make use of a strong magnet.

Abstract: A medicine reservoir (10) is provided for use with a drug delivery device (50). The medicine reservoir (10) is arranged for comprising a drug (13) and comprises a dispensing hole (15) for dispensing the drug (13) into an environment of the drug delivery device (50). The medicine reservoir (10) further comprises a deformable plug (14) which plug (14) is removable by pressure caused by a dispensing action of the drug delivery device (50).

Abstract: A magnetometer includes: a sample (10) comprising a selected nuclear species; an optical source (12) configured to hyperpolarize the selected nuclear species of the sample by illuminating the sample with optical radiation (14) having orbital angular momentum; a radio frequency generator (20, 26, 30, 150, 152) configured to input radio frequency energy (32) to the hyperpolarized selected nuclear species of the sample over a probed range of radio frequencies; a detector (20, 26, 40, 150, 154, 164, 166) configured to detect a frequency of nuclear magnetic resonance excited in the hyperpolarized selected nuclear species of the sample by the input radio frequency energy; and a signal output generator (64, 66) configured to output a signal indicative of magnetic field strength based on the detected frequency of nuclear magnetic resonance.

Abstract: A magnetic resonance system includes a main magnet (12,12?, 12?) which generates a static magnetic field B0 in an examination region (14,14?,14?). A hyperpolarization device (26,26?,26?) directly hyperpolarizes nuclear spins via electromagnetic radiation endowed with orbital angular momentum transverse to the static magnetic field B0 for inducing magnetic resonance. The hyperpolarization device includes an orientation tracking unit (100) which determines an orientation of the endowed photon beam relative to a predefined external coordinate system. An orientation modifier (104) adjusts the orientation of the endowed photon beam to an optimal orientation according to the determined relative orientation.

Abstract: In a pH measurement system, a magnet defines a BO magnetic field with which selected dipoles preferentially align in an examination region. A orbital angular momentum system endows electromagnetic (EM) radiation with orbital angular momentum (OAM) and transmits the OAM endowed EM radiation to the examination region to at least one of (1) enhance the preferential alignment of the selected dipoles with the BO magnetic field and (2) excite the aligned dipoles to resonate. A receive coil receives resonance signals from the resonating dipoles. An analysis or measurement unit determines a pH in the examination region by analyzing the resonance signals.

Abstract: An ingestible capsule (10) is provided for delivery of a drug, the capsule (10) comprises a first module (11) and a second module (12). The first module (11) has at least one drug compartment (13) for comprising an amount of the drug. The drug compartment (13) is sealed by a foil (14) with an embedded conducting heating wire (15). The second (12) module comprises electronics (18) for providing an electrical pulse to the heating wire (15) in order to open the drug compartment (13) by melting the foil (14). The first module (11) and second module (12) comprise interoperable connection means (19) for securing the first module (11) to the second module (12) such that the heating wire (15) is electronically coupled to the electronics (18).

Abstract: A photonic-based hyperpolarisation device is disclosed with an electromagnetic source for emitting photonic radiation having a substantial penetration depth for material of the object, in particular of tissue, to be examined. For example, soft or ultra-soft x-rays are applied. Notably, the photonic-based hyperpolarisation device incorporates a magnet to generate a static magnetic field. Alternatively, the photonic-based hyperpolarisation device is incorporated in an magnetic resonance examination system.

Abstract: A magnetic resonance examination system comprises an RF-system for inducing resonance in polarised dipoles and receiving magnetic resonance signals from an object to be examined and an photonic-based hyperpolarisation device. The an electromagnetic source for emitting photonic radiation: —a mode converter to impart orbital angular momentum to the electromagnetic radiation; a spatial filter to select from the mode converter a diffracted or refracted photonic beam endowed with orbital angular momentum for polarising the dipoles via transferred orbital angular momentum; —a beam controller to apply the photonic beam endowed with orbital angular momentum over an extended target zone.

Abstract: A magnetic resonance examination system comprises an RF-system for inducing resonance in polarised dipoles and receiving magnetic resonance signals from an object to be examined. A thermometry module dervies a temperature distribution of the object to be examined from the magnetic resonance signals. The magnetic resonance examination system further comprises a photonic-based hyperpolarisation device with a photonic source for emitting electromagnetic radiation, a moder converter, such as a phase hologram to impart orbital angular momentum to the electromagnetic radiation and va spatial filter to select from the phase hologram a diffracted photonic beam endowed with orbital angular momentum for polarising the dipoles via transferred orbital angular momentum.