Abstract: The present disclosure relates to compounds of Formula (I): and their prodrugs, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods of their preparation. The compounds disclosed herein are useful for modulating Sigma receptors and have antiviral activity, and may also be useful in the treatment and/or prevention of pain disorders, neurological disorders (e.g., Parkinson's disease and Alzheimer's disease), and cancer.

Abstract: A distributor-type fuel injection pump is provided with a hydraulic injection adjusting mechanism whose injection adjusting piston adjusts the cam gear unit for driving the pump plunger to execute strokes corresponding to the desired position of the start of injection. The injection adjusting piston defines a control space on one side and a spring space receiving a return spring on the other side. The control space is connected via a throttle bore with the pump interior space which is filled with fuel by a delivery pump. The fuel pressure is adjusted by a pressure control valve. To prevent unstable pressure vibrations on the injection adjusting piston, which leads to defects in the operation of the fuel injection pump, the spring space is connected on one side with the suction side of the delivery pump via a first throttle and on the other side with the pressure side of the delivery pump via a second throttle having a smaller throttle cross section.