Patents by Inventor René Bernards

René Bernards has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combined use of PRAME inhibitors and HDAC inhibitors
    Patent number: 7928081
    Abstract: The invention relates to the cancer antigen PRAME (PReferentially expressed Antigen in MElanoma) and its use in a method of treatment of a tumour which comprises administering to a subject in need of treatment an effective amount of an inhibitor of PRAME, in combination with a second agent selected from the group of an inhibitor of HDAC (an HDACi) and a retinoid.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: April 19, 2011
    Inventors: René Bernards, Mirjam Epping, Liming Wang
  • Interaction between cyclin D1 and steroid receptor co-activators and uses thereof in assays
    Patent number: 7012128
    Abstract: The present invention relates to the finding that cyclin D1 interacts in a ligand-independent fashion with coactivators of the SRC-1 family. The direct interaction of cyclin D1 enhances estrogen receptor (ER) mediated transcription and provides a novel target for the development of assays for substances which modulate the cell cycle. The invention provides assay methods for the prevention of growth of tumors, for assays for compounds useful in the prevention of tumors and compounds obtainable by such assays.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: March 14, 2006
    Assignee: TopoTarget UK Limited
    Inventors: René Bernards, Renate Zwijsen