Abstract: Provided is an application of a sphere substance in the preparation of an intravenous injection, relating to the technical field of biomedicine. Intravenous injection of the sphere substance formed by MSC spheres or biomaterials is used as a new in-vivo delivery solution. Compared with the intravenous injection of discrete MSCs, the intravenous injection of the MSC spheres reduces the retention of the MSCs in lungs, and prolongs the-retention time and activity of the MSCs in blood and peripheral tissues, such that therapeutic effects for autoimmune diseases, inflammatory diseases, and tissues and organ injuries can be improved. In addition, the intravenous injection of biomaterial spheres is safe, can carry drugs, biologically active molecules or detection molecules, is applied to diagnosis and treatment of an animal disease model or a patient, is more effective and more durable than monomer molecules, and can also carry a variety of molecules to generate a synergistic effect.

Abstract: A dual-rotor in-wheel motor based on an axial magnetic field and a control method thereof are provided. The dual-rotor in-wheel motor includes an axle and a hub. The axle is fixedly connected to a frame. The hub relatively rotates around the axle. A disc-shaped intermediate stator is fixedly connected on the axle. A left coil assembly and a right coil assembly are fixedly mounted on two sides of the intermediate stator, respectively. A left rotor and a right rotor are respectively arranged on the two sides of the intermediate stator. The left coil assembly drives the left rotor to rotate, and the right coil assembly drives the right rotor to rotate. A left clutch is arranged between the left rotor and the hub, and a right clutch and a speed reduction mechanism are arranged between the right rotor and the hub.

Abstract: A dual-rotor in-wheel motor based on an axial magnetic field and a control method thereof are provided. The dual-rotor in-wheel motor includes an axle and a hub. The axle is fixedly connected to a frame. The hub relatively rotates around the axle. A disc-shaped intermediate stator is fixedly connected on the axle. A left coil assembly and a right coil assembly are fixedly mounted on two sides of the intermediate stator, respectively. A left rotor and a right rotor are respectively arranged on the two sides of the intermediate stator. The left coil assembly drives the left rotor to rotate, and the right coil assembly drives the right rotor to rotate. A left clutch is arranged between the left rotor and the hub, and a right clutch and a speed reduction mechanism are arranged between the right rotor and the hub.

Abstract: A vehicle USB Type-C connector, comprising a cable end member and a board end member engaged together; the CPA is inserted into the engagement groove; the PCB attached male head has an end protruding from a cavity opening on one end of the cable end plastic shell cavity; the encapsulated outer mold is inserted into a cavity opening on another end of the cable end plastic shell cavity; the encapsulated outer mold has an engagement side on two sides thereof and inserted into the lateral engagement groove; the upper lock plate is engaged above the engagement groove, the lower lock plate is inserted into the engagement groove, and the CPA is fastened with the cable end member. The present invention reduces the on-board height and strengthens the liability after engagement.

Abstract: A vehicle USB Type-C connector, comprising a cable end member and a board end member engaged together; the CPA is inserted into the engagement groove; the PCB attached male head has an end protruding from a cavity opening on one end of the cable end plastic shell cavity; the encapsulated outer mold is inserted into a cavity opening on another end of the cable end plastic shell cavity; the encapsulated outer mold has an engagement side on two sides thereof and inserted into the lateral engagement groove; the upper lock plate is engaged above the engagement groove, the lower lock plate is inserted into the engagement groove, and the CPA is fastened with the cable end member. The present invention reduces the on-board height and strengthens the liability after engagement.

Abstract: A dual elastic plate connector includes an engagement portion and a combination portion; the engagement portion including a first elastic plate, a second elastic plate, and a protrusion part; the combination portion combined with a cable; the first elastic plate including a head portion and a stem portion, with a curve structure as a connection portion connected therebetween; the second elastic plate including a head portion and a stem portion, with a curve structure as a connection portion connected therebetween; a bending direction of the two bending structures being arranged in opposite; the stem portion of the first elastic plate overlapping the head portion of the second elastic plate. When the connector is combined with another connector, the yield resistance, the combination stability, and the forward contact force are improved by the reverse stack arrangement between the two elastic plates.

Abstract: A dual elastic plate connector includes an engagement portion and a combination portion; the engagement portion including a first elastic plate, a second elastic plate, and a protrusion part; the combination portion combined with a cable; the first elastic plate including a head portion and a stem portion, with a curve structure as a connection portion connected therebetween; the second elastic plate including a head portion and a stem portion, with a curve structure as a connection portion connected therebetween; a bending direction of the two bending structures being arranged in opposite; the stem portion of the first elastic plate overlapping the head portion of the second elastic plate. When the connector is combined with another connector, the yield resistance, the combination stability, and the forward contact force are improved by the reverse stack arrangement between the two elastic plates.

Abstract: A method of differentiating pluripotent stem cells into mesenchymal stem cells, a culture medium used in the method of differentiating pluripotent stem cells into mesenchymal stem cells and a method of performing tissue and organ regeneration by using the mesenchymal stem cells obtained by differentiation using the method of differentiating pluripotent stem cells into mesenchymal stem cells are provided. The method of differentiating pluripotent stem cells into mesenchymal stem cells comprises differentiating, completely under 3D suspension conditions, pluripotent stem cells into trophoblast-like cells using BMP4 and A8301, and then differentiating the trophoblast-like cells into mesenchymal stem cells. Neither of two differentiation processes needs passaging or replacement of a culture container.

Abstract: The disclosure provided herein relates generally to mesenchymal-like stem cells “hES-T-MiSC” or “T-MSC” and the method of producing the stem cells. The method comprises culturing embryonic stem cells under conditions that the embryonic stem cells develop through an intermediate differentiation of trophoblasts, and culturing the differentiated trophoblasts to hES-T-MSC or T-MSC, T-MSC derived cell and cell lineages “T-MSC-DL” are also described. Disclosed also herein are solutions and pharmaceutical compositions comprising the T-MSC and/or T-MSC-DL, methods of making the T-MSC and T-MSC-DL, and methods of using the T-MSC and T-MSC-DL for treatment and prevention of diseases, specifically, T-MSC and T-MSC-DL are used as immunosuppressive agents to treat multiple sclerosis and autoimmune diseases.

Abstract: The prevent invention relates to connector fields, and more particularly, to an engagement structure of Ethernet connector for vehicle. The plug and the socket are combined and engaged; the plug shell mounted around an outer periphery of the male terminal assembly; the plug shell including a lock plate and a lock seat. When the plug is combined with the cable end socket, the plug shell is inserted into the cable end socket shell, with the circular male terminal combined with the circular female terminal. When the lock plate is pushed from the second end toward the first end of the rail, the ramp elastically crosses over the second end of the bolt member to be engaged between the ramp and the protrusion, and the hook member is engaged with the outer hook.

Abstract: A self-lock structure of Ethernet connector for vehicle, includes a plug self-lock member and a cable end socket self-lock member. When the plug self-lock member and the cable end socket self-lock member are at a first engagement stage, the fastener is inserted into the outer shell, the outer hanger is engaged with the first groove, the first protrusion, the second protrusion, and the inner hanger are engaged with the second groove, the third groove, and the fourth groove, respectively, and the elastic plate is not in a forced status. When the plug self-lock member and the cable end socket self-lock member are at a second engagement stage, the fastener is further inserted into the outer shell, and the first protrusion and the second protrusion are further engaged, respectively, and the elastic plate is in a forced status, enhancing the fastening stability.

Abstract: The present invention relates to methods of generating and expanding pitman embryonic stem cell derived mesenchymal-like stem/stromal cells. These hES-MSCs are characterized at least in part by the low level of expression of IL-6. These cells are useful for the prevention and treatment of T cell related autoimmune disease, especially multiple sclerosis, as well as for delivering agents across the bland-brain barrier and the blood-spinal cord barrier. Also provided is a method of selecting clinical grade hES-MSC and a method of modifying MSC to produced a MSC with specific biomarker profile. The modified MSC are useful for treatment of various diseases.

Abstract: The disclosure provided herein relates generally to mesenchymal-like stem cells “hES-T-MiSC” or “T-MSC” and the method of producing the stem cells. The method comprises culturing embryonic stem cells under conditions that the embryonic stem cells develop through an intermediate differentiation of trophoblasts, and culturing the differentiated trophoblast in hES-T-MSC or T-MSC, T-MSC derived cells and cell lineages “T-MSC-DL” are also described. Disclosed also herein are solutions and pharmaceutical compositions comprising the T-MSC and/or T-MSC-DL, methods of making the T-MSC and T-MSC-DL, and methods of using the T-MSC and T-MSC-DL for treatment and prevention of diseases, specifically. T-MSC and T-MSC-DL are used as immunosuppressive agents to treat multiple sclerosis and autoimmune diseases.

Abstract: An on-vehicle Ethernet connector includes a housing, a terminal, a shield member, and an ESD casing; the housing formed in a barrel shape and having a U-shaped protection structure; the terminal inserted on a bottom of the housing; the shield member inserted in the pillar bodies; the ESD casing mounted around the housing; the U-shaped protection member disposed in the housing and having a plurality of pillar bodies connected and arranged around the terminal; and a sectional view of the plurality of pillar bodies around the terminal being formed in a U shape. The U-shaped protection structure surrounding the terminal prevents the terminal from being accidentally touched, thus increasing the stability and security of the connector. The shield member shields around the terminal. The U-shaped protection structure formed of plastic material provides dust-proof, water-proof, insulation, and accidental contact prevention.

Abstract: The present invention relates to methods of generating and expanding hitman embryonic stem cell derived mesenchymal-like stem/stromal cells. These hES-MSCs are characterized at least in part by the low level of expression of IL-6. These cells are useful for the prevention and treatment of T cell related autoimmune disease, especially multiple sclerosis, as well as for delivering agents across the blood-brain barrier and the blood-spinal cord barrier. Also provided is a method of selecting clinical grade hES-MSC and a method of modifying MSC to produced a MSC with specific biomarker profile. The modified MSC are useful for treatment of various diseases.

Abstract: Disclosed are a device for preparing stem cell spheroids, a method for preparing stem cell spheroids and a method for preserving stem cells which relate to the technical field of preservation and transportation of stem cells. The device for preparing stem cell spheroids disclosed herein includes a substrate. The substrate is provided thereon with culture chambers, each of which has side walls and a bottom wall made of a material incompatible with stem cells. By culturing stem cells with this device, the stem cells may be made into spheroids and thus form stem cell spheroids. The device may be used as a means of preserving or transporting stem cells which makes it possible for stem cells to still have a higher viability and pluripotency even after a long time of preservation, storage and transportation under ambient temperature condition in the form of spheroids.

Abstract: The first method to cause a culture of human and other primate stem cells to directly and uniformly differentiate into a committed cell lineage is disclosed. Treatment of primate stem cells with a single protein trophoblast induction factor causes the cells to transform into human trophoblast cells, the precursor cells of the placenta. Several protein factors including bone morphogenic protein 4 (BMP4), BMP2, BMP7, and growth and differentiation factor 5 can serve as trophoblast-inducting factors.

Abstract: A hub ratchet wheel driving structure includes a central axle having portions respectively received in and coupled to a hub and a ratchet wheel with bearings interfacing therebetween. The hub has an end formed with a diameter-enlarged stepped hole that receives a stop plate to fit therein and is then coupled to a unidirectional grooved ring that is fixed therein through threading engagement. An end of the ratchet wheel is formed with a reduced-diameter stepped shaft that is fit into the diameter-enlarged stepped hole and has a circumferential wall in which horizontal retention troughs are formed for receiving rear ends of the reversal-preventing pawls to disposed therein in a horizontal direction. The ratchet wheel and the reversal-preventing pawls have portions opposite to each other and formed with first and second retention cavities to receive and retain two opposite ends of springs to constrain the reversal-preventing pawls in position.

Abstract: A hub ratchet wheel driving structure includes a central axle having portions respectively received in and coupled to a hub and a ratchet wheel with bearings interfacing therebetween. The hub has an end formed with a diameter-enlarged stepped hole that receives a stop plate to fit therein and is then coupled to a unidirectional grooved ring that is fixed therein through threading engagement. An end of the ratchet wheel is formed with a reduced-diameter stepped shaft that is fit into the diameter-enlarged stepped hole and has a circumferential wall in which horizontal retention troughs are formed for receiving rear ends of the reversal-preventing pawls to disposed therein in a horizontal direction. The ratchet wheel and the reversal-preventing pawls have portions opposite to each other and formed with first and second retention cavities to receive and retain two opposite ends of springs to constrain the reversal-preventing pawls in position.

Abstract: The disclosure provided herein relates generally to mesenchymal-like stem cells “hES-T-MiSC” or “T-MSC” and the method of producing the stem cells. The method comprises culturing embryonic stem cells under conditions that the embryonic stem cells develop through an intermediate differentiation of trophoblasts, and culturing the differentiated trophoblast in hES-T-MSC or T-MSC, T-MSC derived cells and cell lineages “T-MSC-DL” are also described. Disclosed also herein are solutions and pharmaceutical compositions comprising the T-MSC and/or T-MSC-DL, methods of making the T-MSC and T-MSC-DL, and methods of using the T-MSC and T-MSC-DL for treatment and prevention of diseases, specifically. T-MSC and T-MSC-DL are used as immunosuppressive agents to treat multiple sclerosis and autoimmune diseases.