Abstract: A system and method for the electronic monitoring and management of patients and caregivers with various health or disease conditions on the basis of modifiable risk and protective factors that span multiple conditions in order to address multiple co-morbidities and optimize outcomes in those co-morbidities. A system provides a platform with which one or more of medical histories, recent conditions, user information, and real-time measurement data of the patient and caregiver may be organized, tracked, and shared among one or more people who are involved in the caring of the patient to provide coaching (e.g., to one or more of the patient and caregiver) on modifiable factors. In addition to data sharing in a secured, private networking environment, the platform integrates essential functions for people in the various caregiver groups to communicate with a patient and each other in real-time so as to collaborate on the caring of the patient.