Patents by Inventor René Oehlenschlæger
René Oehlenschlæger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9511336Abstract: The present invention relates to a method for producing beads comprising a material capable of gelation, said method comprising the steps of: (i) combining (a) a liquid composition comprising a material capable of gelation; and (b) a first hydrophobic phase; (ii) subjecting the liquid composition and the first hydrophobic phase, to means for emulsification in a first reactor by addition of external mechanical energy creating an emulsion comprising individual droplets comprising the material capable of gelation in the first hydrophobic phase (wherein the material capable of gelation provides a discontinuous phase and the first hydrophobic phase provides a continuous phase); (iii) stabilizing the droplets by transferring the emulsion from the first reactor to a stabilization reactor wherein the emulsion obtained in step (ii) is subjected to means for gelation in order to obtain gelation within 5 minutes or less, and the beads are formed.Type: GrantFiled: October 19, 2015Date of Patent: December 6, 2016Assignee: DPx Holdings B.V.Inventors: Allan Otto Fog Lihme, Marie Bendix Hansen, Rene Oehlenschlaeger Holte, Brian A. Larsen
-
Publication number: 20160038898Abstract: The present invention relates to a method for producing beads comprising a material capable of gelation, said method comprising the steps of: (i) combining (a) a liquid composition comprising a material capable of gelation; and (b) a first hydrophobic phase; (ii) subjecting the liquid composition and the first hydrophobic phase, to means for emulsification in a first reactor by addition of external mechanical energy creating an emulsion comprising individual droplets comprising the material capable of gelation in the first hydrophobic phase (wherein the material capable of gelation provides a discontinuous phase and the first hydrophobic phase provides a continuous phase); (iii) stabilising the droplets by transferring the emulsion from the first reactor to a stabilisation reactor wherein the emulsion obtained in step (ii) is subjected to means for gelation in order to obtain gelation within 5 minutes or less, and the beads are formed.Type: ApplicationFiled: October 19, 2015Publication date: February 11, 2016Applicant: DPX HOLDINGS B.V.Inventors: Allan Otto Fog Lihme, Marie Bendix Hansen, Rene Oehlenschlaeger Holte, Brian A. Larsen
-
Patent number: 9220997Abstract: In the field of expanded bed adsorption chromatography, with particular but not exclusive relevance to disposable expanded bed chromatography columns, a method of conducting upward flow expanded bed chromatography comprising: supplying a liquid via an inlet to a stationary phase medium contained in a column, allowing adsorption of at least one component from the liquid by the stationary phase medium, withdrawing the liquid from the column via an outlet, regulating the expansion of the stationary phase medium by regulation of the flow rate of the liquid through at least the inlet, and restricting any overpressure in the headspace of the column to not more than the outside pressure plus 0.1 bar, is provided. In addition, apparatus for use in said method, in particular columns for use in expanded bed chromatography, are provided.Type: GrantFiled: March 28, 2008Date of Patent: December 29, 2015Assignee: DPX HOLDINGS B.V.Inventors: Allan Lihme, René Oehlenschläger Holte, Kurt Hauge Jensen, Tony Christensen
-
Patent number: 9192907Abstract: The present invention relates to a method for producing beads comprising a material capable of gelation, said method comprising the steps of: (i) combining (a) a liquid composition comprising a material capable of gelation; and (b) a first hydrophobic phase; (ii) subjecting the liquid composition and the first hydrophobic phase, to means for emulsification in a first reactor by addition of external mechanical energy creating an emulsion comprising individual droplets comprising the material capable of gelation in the first hydrophobic phase (wherein the material capable of gelation provides a discontinuous phase and the first hydrophobic phase provides a continuous phase); (iii) stabilizing the droplets by transferring the emulsion from the first reactor to a stabilization reactor wherein the emulsion obtained in step (ii) is subjected to means for gelation in order to obtain gelation within 5 minutes or less, and the beads are formed.Type: GrantFiled: December 2, 2008Date of Patent: November 24, 2015Assignee: DPX Holdings B.V.Inventors: Allan Otto Fog Lihme, Marie Bendix Hansen, Rene Oehlenschlaeger Holte, Brian Larsen
-
Publication number: 20110018153Abstract: The present invention relates to a method for producing beads comprising a material capable of gelation, said meth comprising the steps of: (i) combining (a) a liquid composition comprising a material capable of gelation; and (b) a first hydrophobic phase; (ii) subjecting the liquid composition and the first hydrophobic phase, to means for emulsification in a first reactor by addition of external mechanical energy creating an emulsion comprising individual droplets comprising the material capable of gelation in the first hydrophobic phase (wherein the material capable of gelation provides a discontinuous phase and the first hydrophobic phase provides a continuous phase); (iii) stabilising the droplets by transferring the emulsion from the first reactor to a stabilisation reactor wherein the emulsion obtained in step (ii) is subjected to means for gelation in order to obtain gelation within 5 minutes or less, and the beads are formed.Type: ApplicationFiled: December 2, 2008Publication date: January 27, 2011Inventors: Allan Otto Fog Lihme, Marie Bendix Hansen, Rene Oehlenschlaeger Holte, Brian Larsen
-
Publication number: 20100084344Abstract: In the field of expanded bed adsorption chromatography, with particular but not exclusive relevance to disposable expanded bed chromatography columns, a method of conducting upward flow expanded bed chromatography comprising: supplying a liquid via an inlet to a stationary phase medium contained in a column, allowing adsorption of at least one component from the liquid by the stationary phase medium, withdrawing the liquid from the column via an outlet, regulating the expansion of the stationary phase medium by regulation of the flow rate of the liquid through at least the inlet, and restricting any overpressure in the headspace of the column to not more than the outside pressure plus 0.1 bar, is provided. In addition, apparatus for use in said method, in particular columns for use in expanded bed chromatography, are provided.Type: ApplicationFiled: March 28, 2008Publication date: April 8, 2010Inventors: Allan Lihme, René Oehlenschläger Holte, Kurt Hauge Jensen, Tony Christensen
-
Patent number: 6620326Abstract: The present application describes various improvements and further developments to the Expanded Bed Adsorption (EBA) technology. In particular, the application describes an EBA process where elution is performed in fluidized mode, i.e., in expanded bed mode, the so-called All Expanded Process. This improvement which is based on the use of controlled density particles, e.g., particles having a density of at least 1.3 g/ml, provides valuable advantages with respect to use of reduced amounts of elution buffer.Type: GrantFiled: March 12, 2001Date of Patent: September 16, 2003Assignee: Upfront Chromatography A/SInventors: Allan Otto Fog Lihme, René Oehlenschlæger, Brian A. Olsen, Elias Zafirakos