Abstract: The invention relates to an immune cell comprising at least one Fc receptor on its surface, characterised in that a hybrid molecule is grafted onto the Fc receptor, said hybrid molecule comprising at least one antibody Fc fragment covalently bound to at least one fibrin-derived peptide comprising one or more citrullyl residue(s). The present invention also relates to the uses of such a grafted cell, as well as its method of production.

Abstract: The invention relates to a hybrid molecule comprising a fibrin-derived citrullinated peptide and an antibody or antibody fragment which binds to CD38 and/or CD138, the uses of such a hybrid molecule and its method of production.

Abstract: Modular trailer for motor vehicles, with frame stretched length and width, doubling its floor space without changing the front angle of the coupling tongue (9). The frame consists of four channel side rails of identical length (1) and (2), two to two coupled, for carrying the extensions that slide in, one on one side (front) (3) the other on the opposite side (back) (4) and five cross members (5) on which nest and slide on both sides the 2 additional extension members (6) to allow so the width variation of the chassis. The change of the axle works is made on the same way. (7) and (8). The coupling tongue receives an extension on each arm. It allows the transport of raw materials (when it is folded), or large but light material (eg insulation wall plates . . . ) In the deployed versions deployed, it allows transporting a motorcycle or a boat if the chassis receives the appropriate accessories; its look is completely changed if the frame receives a composite body.

Abstract: The present invention relates to a cosmetic or pharmaceutical composition comprising, in a physiologically acceptable medium, a purified natural or synthetic epidermis-specific polypeptide which is involved in horny layer cell cohesion. The invention also relates to a cosmetic or pharmaceutical composition comprising a mixture of polypeptides derived from the proteolysis of the purified polypeptide of the present invention. The present invention further relates to a method for strengthening horny layer cell cohesion which comprises applying the cosmetic or pharmaceutical composition of the present invention to the skin. Finally, the present invention relates to a method for reducing horny layer cell cohesion, and thereby promoting exfoliation, wherein said method comprises applying to the skin a cosmetic or pharmaceutical composition comprising an effective amount of at least one protease active on the polypeptide of the present invention.