Patents by Inventor René Smits
René Smits has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230406847Abstract: The present invention relates to novel compounds that bind to the prostate-specific membrane antigen (PSMA)-binding and their use in the diagnosis and treatment of certain diseases where PSMA is upregulated.Type: ApplicationFiled: November 11, 2021Publication date: December 21, 2023Applicant: ABX ADVANCED BIOCHEMICAL COMPOUNDS GMBHInventors: Alexander HOEPPING, Hans-Joachim LANKAU, Ronny HESSE, Klaus KOPKA, Ulrike BAUDER WÜST, Christian LIS, René SMITS, Jan MOLLITOR, Kristine SCHEIBE, Alexandra GEISSLER
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Publication number: 20220370648Abstract: Embodiments of the present disclosure provide compositions comprising compounds useful to make radiotracers for positron emission tomography imaging, as well as methods for making and using these compositions.Type: ApplicationFiled: May 7, 2021Publication date: November 24, 2022Applicant: CellSight Technologies Inc.Inventors: Jelena Levi, Ananth Srinivasan, Alexander Hoepping, Rene Smits
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Patent number: 11053200Abstract: A method for producing a radiofluorinated compound having an aromatic or heteroaromatic ring carrying [18F] fluorine as first substituent, a bonding unit, which can bind to a peptide or peptide mimetic, and a spacer group connected via bond A1 to the bonding unit and via bond A2 to the ring, wherein the bonding unit has second substituent(s) —OH, —CONH, and/or —COOH. The steps include (a) providing a precursor having the ring carrying a substituent Y, bonding unit with the second substituent(s), and spacer group, wherein substituent Y is —N+(R1R2R3), —NO2, —Cl, —Br, —F, or —I, and R1, R2, and R3 are independently C1-C6 alkyl; and (b) reacting the precursor with a [18F] fluoride anion in the presence of an activation salt to the radiofluorinated compound, which has a cation N+(R4R5R6R7) with R4, R5, R6, and R7 being independently C1-C6 alkyl, wherein the substituent Y is replaced by [18F] fluoride.Type: GrantFiled: January 31, 2020Date of Patent: July 6, 2021Assignee: ABX advanced biochemical compounds GmbHInventors: René Martin, René Smits, Ronny Hesse, Alexander Hoepping, Marco Müller, Sandra Hübner
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Patent number: 10759760Abstract: A method for producing a radiofluorinated compound having an aromatic or heteroaromatic ring carrying [18F] fluorine as first substituent, a bonding unit, which can bind to a peptide or peptide mimetic, and a spacer group connected via bond A1 to the bonding unit and via bond A2 to the ring, wherein the bonding unit has second substituent(s) —OH, —CONH, and/or —COOH. The steps include (a) providing a precursor having the ring carrying a substituent Y, bonding unit with the second substituent(s), and spacer group, wherein substituent Y is —N+(R1R2R3), —NO2, —Cl, —Br, —F, or —I, and R1, R2, and R3 are independently C1-C6 alkyl; and (b) reacting the precursor with a [18F] fluoride anion in the presence of an activation salt to the radiofluorinated compound, which has a cation N+(R4R5R6R7) with R4, R5, R6, and R7 being independently C1-C6 alkyl, wherein the substituent Y is replaced by [18F] fluoride.Type: GrantFiled: November 17, 2017Date of Patent: September 1, 2020Assignee: ABX ADVANCED BIOCHEMICAL COMPOUNDS GMBHInventors: René Martin, René Smits, Ronny Hesse, Alexander Hoepping, Marco Müller, Sandra Hübner
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Publication number: 20200165204Abstract: A method for producing a radiofluorinated compound having an aromatic or heteroaromatic ring carrying [18F] fluorine as first substituent, a bonding unit, which can bind to a peptide or peptide mimetic, and a spacer group connected via bond A1 to the bonding unit and via bond A2 to the ring, wherein the bonding unit has second substituent(s) —OH, —CONH, and/or —COOH. The steps include (a) providing a precursor having the ring carrying a substituent Y, bonding unit with the second substituent(s), and spacer group, wherein substituent Y is —N+(R1R2R3), —NO2, —Cl, —Br, —F, or —I, and R1, R2, and R3 are independently C1-C6 alkyl; and (b) reacting the precursor with a [18F] fluoride anion in the presence of an activation salt to the radiofluorinated compound, which has a cation N+(R4R5R6R7) with R4, R5, R6, and R7 being independently C1-C6 alkyl, wherein the substituent Y is replaced by [18F] fluoride.Type: ApplicationFiled: January 31, 2020Publication date: May 28, 2020Applicant: ABX advanced biochemical compounds GmbHInventors: René MARTIN, René SMITS, Ronny HESSE, Alexander HOEPPING, Marco MÜLLER, Sandra HÜBNER
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Publication number: 20190263756Abstract: A method for producing a radiofluorinated compound having an aromatic or heteroaromatic ring carrying [18F] fluorine as first substituent, a bonding unit, which can bind to a peptide or peptide mimetic, and a spacer group connected via bond A1 to the bonding unit and via bond A2 to the ring, wherein the bonding unit has second substituent(s) —OH, —CONH, and/or —COOH. The steps include (a) providing a precursor having the ring carrying a substituent Y, bonding unit with the second substituent(s), and spacer group, wherein substituent Y is —N+(R1R2R3), —NO2, —Cl, —Br, —F, or —I, and R1, R2, and R3 are independently C1-C6 alkyl; and (b) reacting the precursor with a [18F] fluoride anion in the presence of an activation salt to the radiofluorinated compound, which has a cation N+(R4R5R6R7) with R4, R5, R6, and R7 being independently C1-C6 alkyl, wherein the substituent Y is replaced by [18F] fluoride.Type: ApplicationFiled: November 17, 2017Publication date: August 29, 2019Applicant: ABX ADVANCED BIOCHEMICAL COMPOUNDS GMBHInventors: René MARTIN, René SMITS, Ronny HESSE, Alexander HOEPPING, Marco MÜLLER, Sandra HÜBNER
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Patent number: 9428497Abstract: The invention relates to a compound of formula Ia or Ib wherein R1 represents —CO2R3, —COR4 or —R5, wherein R3 represents unsubstituted or substituted C1-C6 alkyl, R4 represents hydrogen, unsubstituted or substituted C1-C6 alkyl, and R5 represents hydrogen, unsubstituted or substituted C1-C6 alkyl, R2 represents —N+(R6)(R7)(R8)X? or a nitro group, wherein R6, R7, R8 independently of each other represent unsubstituted or substituted C1-C6 alkyl or unsubstituted or substituted —(CH2)n- with n=1 to 12 provided that at least two of the substituents R6R7R8 are C1-C6 alkyl, and X? represents a halide, sulphonate, unsubstituted or substituted acetate, sulphate, hydrogen sulphate, nitrate, perchlorate, or oxalate.Type: GrantFiled: July 31, 2012Date of Patent: August 30, 2016Assignees: ABX ADVANCED BIOCHEMICAL COMPOUNDS GMBH, HELMHOLTZ-ZENTRUM DRESDEN-ROSSENDORF E.V., UNIVERSITAET LEIPZIGInventors: René Smits, Alexander Hoepping, Steffen Fischer, Achim Hiller, Winnie Deuther-Conrad, Peter Brust, Jörg Steinbach, Marianne Patt, Jörg Thomas Patt, Osama Sabri
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Publication number: 20150259338Abstract: The invention relates to a compound of formula Ia or Ib wherein R1 represents —CO2R3, —COR4 or —R5, wherein R3 represents unsubstituted or substituted C1-C6 alkyl, R4 represents hydrogen, unsubstituted or substituted C1-C6 alkyl, and R5 represents hydrogen, unsubstituted or substituted C1-C6 alkyl, R2 represents —N+(R6)(R7)(R8)X? or a nitro group, wherein R6, R7, R8 independently of each other represent unsubstituted or substituted C1-C6 alkyl or unsubstituted or substituted —(CH2)n- with n=1 to 12 provided that at least two of the substituents R6R7R8 are C1-C6 alkyl, and X? represents a halide, sulphonate, unsubstituted or substituted acetate, sulphate, hydrogen sulphate, nitrate, perchlorate, or oxalateType: ApplicationFiled: July 31, 2012Publication date: September 17, 2015Applicants: ABX ADVANCED BIOCHEMICAL COMPOUNDS GMBH, UNIVERSITAET LEIPZIG, HELMHOLTZ-ZENTRUM DRESDEN-ROSSENDORF E.V.Inventors: René Smits, Alexander Hoepping, Steffen Fischer, Achim Hiller, Winnie Deuther-Conrad, Peter Brust, Jörg Steinbach, Marianne Patt, Jörg Thomas Patt, Osama Sabri