Patents by Inventor Renan B. Sper

Renan B. Sper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250144246
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Application
    Filed: October 17, 2024
    Publication date: May 8, 2025
    Inventors: Lucas Benjamin HARRINGTON, Wiputra Jaya HARTONO, Pei-Qi LIU, Darren Bo Yee LO, Renan B. SPER
  • Publication number: 20240384249
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids, including editing target nucleic acids, as well as, the treatment of diseases and disorders associated with the dystrophin gene (DMD).
    Type: Application
    Filed: May 30, 2024
    Publication date: November 21, 2024
    Inventors: Lucas Benjamin HARRINGTON, Wiputra Jaya HARTONO, Pei-Qi LIU, Darren Bo Yee LO, Renan B. SPER
  • Publication number: 20230121577
    Abstract: Therapeutic methods and compositions for the in utero or postnatal treatment of diseases associated with alternative splicing are provided. Compositions of the disclosure include delivery nanoparticles with an inner region surrounded by a nucleic acid scaffolding that is, in turn, linked to therapeutic agents that promote healthy mRNA splicing phenotypes in fetal cells when the compositions are delivered to a fetus in utero or in a patient after birth.
    Type: Application
    Filed: April 14, 2021
    Publication date: April 20, 2023
    Inventors: Tippi MacKenzie, Tejal Ashwin Desai, Stephan Sanders, Xiao Huang, Renan B. Sper