Patents by Inventor Renata Grifantini

Renata Grifantini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunogenic compositions containing bacterial outer membrane vesicles and therapeutic uses thereof
    Patent number: 11066453
    Abstract: The present invention provides means and products for the stimulation of an immune response against tumors in a subject in need thereof. More specifically the invention provides immunogenic compositions containing bacterial outer membrane vesicles loaded with tumor antigens, fusion proteins comprising a bacterial protein and a tumor antigen, and isolated bacterial outer membrane vesicles (OMVs) containing said fusion proteins. The fusion proteins, OMVs and immunogenic compositions according to the invention are used in the prevention and treatment of tumors.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: July 20, 2021
    Assignee: BIOMVIS SRL
    Inventors: Guido Grandi, Valeria Cafardi, Laura Fantappie′, Renata Grifantini, Alberto Grandi
  • Tumor marker, monoclonal antibodies and methods of use thereof
    Patent number: 10359428
    Abstract: Newly identified proteins as markers for the detection of colon, ovary, kidney, esophagus and prostate tumors, or as therapeutic targets for their treatment; affinity ligands and particularly antibodies capable of selectively interacting with the tumor markers and methods for tumor diagnosis and therapy using such antibodies.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: July 23, 2019
    Assignee: EXTERNAUTICS S.P.A.
    Inventors: Renata Grifantini, Piero Pileri, Susanna Campagnoli, Alberto Grandi, Matteo Parri, Jin Boquan
  • Ovary tumor markers and methods of use thereof
    Patent number: 10288617
    Abstract: Newly identified proteins as markers for the detection of ovary tumors, or as therapeutic targets for treatment thereof; affinity ligands capable of selectively interacting with the newly identified markers, methods for tumor diagnosis and therapy using the same.
    Type: Grant
    Filed: October 26, 2010
    Date of Patent: May 14, 2019
    Assignee: Externautics Spa
    Inventors: Renata Grifantini, Piero Pileri, Susanna Campagnoli, Alberto Grandi, Matteo Parri, Andrea Pierleoni, Renzo Nogarotto
  • IMMUNOGENIC COMPOSITIONS CONTAINING BACTERIAL OUTER MEMBRANE VESICLES AND THERAPEUTIC USES THEREOF
    Publication number: 20180353587
    Abstract: The present invention provides means and products for the stimulation of an immune response against tumors in a subject in need thereof. More specifically the invention provides immunogenic compositions containing bacterial outer membrane vesicles loaded with tumor antigens, fusion proteins comprising a bacterial protein and a tumor antigen, and isolated bacterial outer membrane vesicles (OMVs) containing said fusion proteins. The fusion proteins, OMVs and immunogenic compositions according to the invention are used in the prevention and treatment of tumors.
    Type: Application
    Filed: May 17, 2016
    Publication date: December 13, 2018
    Applicant: UNIVERSITA' DEGLI STUDI DI TRENTO
    Inventors: Guido Grandi, Valeria Cafardi, Laura Fantappie', Renata Grifantini, Alberto Grandi
  • Ovary Tumor Markers And Methods Of Use Thereof
    Publication number: 20180313841
    Abstract: Newly identified proteins as markers for the detection of ovary tumors, or as therapeutic targets for treatment thereof; affinity ligands capable of selectively interacting with the newly identified markers, methods for tumor diagnosis and therapy using the same.
    Type: Application
    Filed: March 27, 2018
    Publication date: November 1, 2018
    Inventors: Renata Grifantini, Piero Pileri, Susanna Campagnoli, Alberto Grandi, Matteo Parri, Andrea Pierleoni, Renzo Nogarotto
  • Breast Tumor Markers And Methods Of Use Thereof
    Publication number: 20170227543
    Abstract: Newly identified proteins as markers for the detection of breast tumors, or as therapeutic targets for treatment thereof; affinity ligands capable of selectively interacting with the newly identified markers, as well as methods for tumor diagnosis and therapy using such ligands.
    Type: Application
    Filed: October 31, 2016
    Publication date: August 10, 2017
    Applicant: Externautics SpA
    Inventors: Renata Grifantini, Piero Pileri, Susanna Campagnoli, Alberto Grandi, Matteo Parri, Andrea Pierleoni, Renzo Nogarotto
  • TUMOR MARKER, MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF
    Publication number: 20160131656
    Abstract: Newly identified proteins as markers for the detection of colon, ovary, kidney, esophagus and prostate tumors, or as therapeutic targets for their treatment; affinity ligands and particularly antibodies capable of selectively interacting with the tumor markers and methods for tumor diagnosis and thereapy using such antibodies.
    Type: Application
    Filed: June 13, 2014
    Publication date: May 12, 2016
    Inventors: Renata Grifantini, Piero Pileri, Susanna Campagnoli, Alberto Grandi, Matteo Parri, Jin Boquan
  • Tumor markers and methods of use thereof
    Patent number: 9182404
    Abstract: The invention provides newly identified proteins as markers for the detection of tumors, or as targets for their treatment, particularly of tumors affecting lung, colon, breast, ovary; affinity ligands capable of selectively interacting with the newly identified markers; methods of screening a tissue sample for malignancy, for determining the presence of a tumor in a subject and for screening a test compound as an antitumor candidate; a diagnostic kit.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: November 10, 2015
    Assignee: EXTERNAUTICS S.P.A.
    Inventors: Renata Grifantini, Piero Pileri, Susanna Campagnoli, Andrea Pierleoni, Renzo Nogarotto
  • Prostate Tumor Markers And Methods Of Use Thereof
    Publication number: 20150093396
    Abstract: Newly identified proteins as markers for the detection of prostate tumors, or as targets for their therapeutic treatment, affinity ligands capable of selectively interacting with said markers as well as methods for tumor diagnosis and therapy using the same.
    Type: Application
    Filed: December 5, 2014
    Publication date: April 2, 2015
    Inventors: Renata Grifantini, Piero Pileri, Susanna Campagnoli, Alberto Grandi, Matteo Parri, Andrea Pierleoni, Renzo Nogarotto
  • Prostate tumor markers and methods of use thereof
    Patent number: 8921058
    Abstract: Newly identified proteins as markers for the detection of prostate tumors, or as targets for their therapeutic treatment, affinity ligands capable of selectively interacting with said markers as well as methods for tumor diagnosis and therapy using the same.
    Type: Grant
    Filed: October 26, 2010
    Date of Patent: December 30, 2014
    Assignee: Externautics SpA
    Inventors: Renata Grifantini, Piero Pileri, Susanna Campagnoli, Alberto Grandi, Matteo Parri, Andrea Pierleoni, Renzo Nogarotto
  • Tumor Marker and Methods of Use Thereof
    Publication number: 20130137106
    Abstract: Newly identified proteins as markers for the detection of breast, colon, lung and ovary tumors, or as therapeutic targets for their treatment, affinity ligands capable of selectively interacting with the newly identified markers and methods for tumor diagnosis and therapy using such ligands.
    Type: Application
    Filed: April 29, 2011
    Publication date: May 30, 2013
    Applicant: EXTERNAUTICS S.P.A.
    Inventors: Renata Grifantini, Piero Pileri, Susanna Campagnoli, Matteo Parri, Alberto Grandi, Andrea Pierleoni
  • Colon and Rectal Tumor Markers and Methods of Use Thereof
    Publication number: 20130022983
    Abstract: Newly identified proteins as markers for the detection of colon and rectal tumors, or as therapeutic targets for treatment thereof; affinity ligands capable of selectively interacting with the newly identified markers, as well as methods for tumor diagnosis and therapy using such ligands.
    Type: Application
    Filed: October 26, 2010
    Publication date: January 24, 2013
    Applicant: EXTERNAUTICS S.P.A.
    Inventors: Renata Grifantini, Piero Pileri, Susanna Campagnoli, Alberto Grandi, Matteo Parri, Andrea Pierleoni, Renzo Nogarotto
  • Breast Tumor Markers and Methods of Use Thereof
    Publication number: 20130017546
    Abstract: Newly identified proteins as markers for the detection of breast tumors, or as therapeutic targets for treatment thereof; affinity ligands capable of selectively interacting with the newly identified markers, as well as methods for tumor diagnosis and therapy using such ligands.
    Type: Application
    Filed: October 26, 2010
    Publication date: January 17, 2013
    Applicant: Externautics S.P.A.
    Inventors: Renata Grifantini, Piero Pileri, Susanna Campagnoli, Alberto Grandi, Matteo Parri, Andrea Pierleoni, Renzo Nogarotto
  • Ovary Tumor Markers and Methods of Use Thereof
    Publication number: 20130004955
    Abstract: Newly identified proteins as markers for the detection of ovary tumors, or as therapeutic targets for treatment thereof; affinity ligands capable of selectively interacting with the newly identified markers, methods for tumor diagnosis and therapy using the same.
    Type: Application
    Filed: October 26, 2010
    Publication date: January 3, 2013
    Applicant: EXTERNAUTICS S.P.A.
    Inventors: Renata Grifantini, Piero Pileri, Susanna Campagnoli, Alberto Grandi, Matteo Parri, Andrea Pierleoni, Renzo Nogarotto
  • Prostate Tumor Markers and Methods of Use Thereof
    Publication number: 20120322074
    Abstract: Newly identified proteins as markers for the detection of prostate tumors, or as targets for their therapeutic treatment, affinity ligands capable of selectively interacting with said markers as well as methods for tumor diagnosis and therapy using the same.
    Type: Application
    Filed: October 26, 2010
    Publication date: December 20, 2012
    Applicant: EXTERNAUTICS S.P.A.
    Inventors: Renata Grifantini, Piero Pileri, Susanna Campagnoli, Alberto Grandi, Matteo Parri, Andrea Pierleoni, Renzo Nogarotto
  • Lung Tumor Markers and Methods of Use Thereof
    Publication number: 20120322075
    Abstract: Newly identified proteins as markers for the detection of lung tumors, or as therapeutic targets for their treatment, affinity ligands capable of selectively interacting with the newly identified markers and methods for tumor diagnosis and therapy using such ligands.
    Type: Application
    Filed: October 26, 2010
    Publication date: December 20, 2012
    Applicant: EXTERNAUTICS S.P.A.
    Inventors: Renata Grifantini, Piero Pileri, Susanna Campagnoli, Alberto Grandi, Matteo Parri, Andrea Pierleoni, Renzo Nogarotto
  • TUMOR MARKERS AND METHODS OF USE THEREOF
    Publication number: 20120052071
    Abstract: The invention provides newly identified proteins as markers for the detection of tumors, or as targets for their treatment, particularly of tumors affecting lung, colon, breast, ovary; affinity ligands capable of selectively interacting with the newly identified markers; methods of screening a tissue sample for malignancy, for determining the presence of a tumor in a subject and for screening a test compound as an antitumor candidate; a diagnostic kit.
    Type: Application
    Filed: January 27, 2010
    Publication date: March 1, 2012
    Applicant: Externautics S.p.A.,
    Inventors: Renata Grifantini, Piero Pileri, Susanna Campagnoli, Andrea Pierleoni, Renzo Nogarotto
  • TUMOR MARKERS AND METHODS OF USE THEREOF
    Publication number: 20120045439
    Abstract: The invention provides newly identified proteins as markers for the detection of tumors, or as targets for their treatment, particularly of tumors affecting lung, colon, breast, ovary; affinity ligands capable of selectively interacting with the newly identified markers; methods of screening a tissue sample for malignancy, for determining the presence of a tumor in a subject and for screening a test compound as an antitumor candidate; a diagnostic kit.
    Type: Application
    Filed: January 27, 2010
    Publication date: February 23, 2012
    Applicant: EXTERNAUTICS S.P.A.,
    Inventors: Renata Grifantini, Piero Pileri, Susanna Campagnoli, Andrea Pierleoni, Renzo Nogarotto
  • Process for the production of D-&agr;-amino acids
    Patent number: 6566105
    Abstract: A process is described for the production of D-&agr;-amino acids by the stereospecific conversion of racemic mixtures of 5-substituted hydantoins using a microorganism transformed with a plasmid which expresses an enzymatic system which converts the hydantoins into the corresponding D-&agr;-amino acids without the requirement for inducers. Also described is a plasmid containing genes encoding the enzymatic system, and a microorganism transformed with the plasmid.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: May 20, 2003
    Assignee: Eniricerche S.p.A.
    Inventors: Renata Grifantini, Gianni Frascotti, Giuliano Galli, Guido Grandi
  • IL-1 receptor antagonists with enhanced inhibitory activity
    Patent number: 5922573
    Abstract: DNA molecules that code for IL-1 antagonists with improved biological activity arc described. DNA molecules coding for improved IL-1 antagonists inserted into expression vectors and host cells transformed with the said vectors containing the DNA coding for improved IL-1 antagonists and a method for the production of improved IL-1 antagonists in essentially pure form are also described. Preparations that can be injected or can be administered by some other route, consisting of a pharmaceutical preparation of the said mutants, are particularly useful as drugs in the field of therapy.
    Type: Grant
    Filed: April 15, 1997
    Date of Patent: July 13, 1999
    Assignee: Dompe' S.p.A.
    Inventors: Diana Boraschi, Paola Bossu, Paolo Ruggiero, Giovanni Macchia, Aldo Tagliabue, Francesco Frigerio, Renata Grifantini, Gianni Frascotti, Guido Grandi