Abstract: The present disclosure provides compositions and methods for the genetic modification of cells, including, but not limited to, hepatocytes. The compositions and methods can comprise lipid nanoparticles, wherein the lipid nanoparticles comprise at least one bioreducible ionizable cationic lipid, at least one structural lipid, at least one phospholipid and at least one PEGylated lipid.

Abstract: Disclosed are methods and compositions for obtaining modified induced pluripotent stem cells (iPSCs) and derivative cells with stable and functional genetic modifications at selected sites. Also provided are cell populations or clonally differentiated cell derived from modified iPSCs, which comprise targeted integration of one or more exogenous polynucleotides, and/or indels in one or more selected gene loci.

Abstract: Compositions and methods are provided for depletion of pluripotent cells. In one embodiment of the invention, methods are provided for depletion of pluripotent cells from a mixed population of differentiated cells and stem cells, to provide a population of cells substantially free of pluripotent stem cells.

Abstract: The present invention relates to a locking system designed for packages intended particularly for packing make-up comprising refills without the use of adhesives.

Abstract: A packaging combination characterized by including a casing (1) having at least two openings (5, 6), and a casing coupler; a container (2) having a mouth (11), a container coupler and a container attachment mechanism, wherein the container (2) is at least partially housed inside the casing (1) and its container coupler cooperate at least partially with the casing coupler; a sealing lid (4) having sealing lid attachment structure, wherein the sealing lid (4) can be fastened to the container (2), with the lid attachment structure cooperating with the container attachment mechanism.

Abstract: A package with a refill cartridge for baton shaped products, such as lipsticks and face bases. The package comprises an outer envelope comprising a cap and a body portion, from the base of which the inner axial protrusion extends, and a refill cartridge to be fitted into the base of the outer envelope. The refill cartridge comprises two tubular walls that cooperated to raise and lower the baton-shaped product for the application to the user. The end of the second tubular wall of the cartridge is folded inwards and upwards so as to form a holding surface that receives the axial protrusion and keeps it motionless.

Abstract: A package with a refill cartridge for baton shaped products, such as lipsticks and face bases. The package comprises an outer envelope comprising a cap and a body portion, from the base of which the inner axial protrusion extends, and a refill cartridge to be fitted into the base of the outer envelope. The refill cartridge comprises two tubular walls that cooperated to raise and lower the baton-shaped product for the application to the user. The end of the second tubular wall of the cartridge is folded inwards and upwards so as to form a holding surface that receives the axial protrusion and keeps it motionless.

Abstract: The present invention refers to a packaging combination characterized by comprising a casing (1) having at least two openings (5, 6), and a casing coupler; a container (2) having a mouth (11), a container coupler and a container attachment mechanism, wherein the container (2) is at least partially housed inside the casing (1) and its container coupler cooperate at least partially with the casing coupler; a sealing lid (4) having sealing lid attachment structure, wherein the sealing lid (4) can be fastened to the container (2), with the lid attachment structure cooperating with the container attachment mechanism.