Patents by Inventor Renate Den-Bouwmeester

Renate Den-Bouwmeester has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for isolation of highly pure von willebrand factor
    Patent number: 6103693
    Abstract: The invention relates to a method for isolation of highly pure von Willebrand Factor in which recombinant von Willebrand Factor (rvWF) is chromatographically purified by anion exchange chromatography on an anion exchanger of the quaternary amino type in a buffer solution comprising buffer substances and optionally salt.The buffer solutions are preferably free of stabilizers, amino acids and other additives. According to this method, highly pure recombinant vWF can be obtained, which is free from blood plasma proteins, especially free from Factor VIII, and is physiologically active.Further, the invention relates to a pharmaceutical preparation that contains rvWF, which is comprised of multimers with a high structural integrity.
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: August 15, 2000
    Assignee: Immuno Aktiengesellschaft
    Inventors: Bernhard Fischer, Artur Mitterer, Friedrich Dorner, Hans-Peter Schwarz, Peter Turecek, Johann Eibl, Falko-Guenter Falkner, Uwe Schlokat, Wolfgang Mundt, Manfred Reiter, Renate Den-Bouwmeester
  • Method for isolation of highly pure von willebrand factor
    Patent number: 5880265
    Abstract: The invention relates to a method for isolation of highly pure von Willebrand Factor in which recombinant von Willebrand Factor (rvWF) is chromatographically purified by anion exchange chromatography on an anion exchanger of the quaternary amino type in a buffer solution comprising buffer substances and optionally salt.The buffer solutions are preferably free of stabilizers, amino acids and other additives. According to this method, highly pure recombinant vWF can be obtained, which is free from blood plasma proteins, especially free from Factor VIII, and is physiologically active.Further, the invention relates to a pharmaceutical preparation that contains rvWF, which is comprised of multimers with a high structural integrity.
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: March 9, 1999
    Assignee: Immuno Aktiengesellschaft
    Inventors: Bernhard Fischer, Artur Mitterer, Friedrich Dorner, Hans-Peter Schwarz, Peter Turecek, Johann Eibl, Falko-Guenter Falkner, Uwe Schlokat, Wolfgang Mundt, Manfred Reiter, Renate Den-Bouwmeester
  • Method for isolation of highly pure von Willebrand Factor
    Patent number: 5877152
    Abstract: The invention relates to a method for isolation of highly pure von Willebrand Factor in which recombinant von Willebrand Factor (rvWF) is chromatographically purified by anion exchange chromatography on an anion exchanger of the quaternary amino type in a buffer solution comprising buffer substances and optionally salt.The buffer solutions are preferably free of stabilizers, amino acids and other additives. According to this method, highly pure recombinant vWF can be obtained, which is free from blood plasma proteins, especially free from Factor VIII, and is physiologically active.
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: March 2, 1999
    Assignee: Immuno Aktiengesellschaft
    Inventors: Bernhard Fischer, Artur Mitterer, Friedrich Dorner, Hans-Peter Schwarz, Peter Turecek, Johann Eibl, Falko-Guenter Falkner, Uwe Schlokat, Wolfgang Mundt, Manfred Reiter, Renate Den-Bouwmeester
  • Method for isolation of highly pure von Willebrand Factor
    Patent number: 5854403
    Abstract: The invention relates to a method for isolation of highly pure von Willebrand Factor in which recombinant von Willebrand Factor (rvWF) is chromatographically purified by anion exchange chromatography on an anion exchanger of the quaternary amino type in a buffer solution comprising buffer substances and optionally salt. The buffer solutions are preferably free of stabilizers, amino acids and other additives. According to this method, highly pure recombinant rvWF can be obtained, which is free from blood plasma proteins, especially free from Factor VIII, and is physiologically active. Further, the invention relates to a pharmaceutical preparation that contains rvWF, which comprises mulitimers with a high structural integrity.
    Type: Grant
    Filed: May 24, 1996
    Date of Patent: December 29, 1998
    Assignee: Immuno Aktiengesellschaft
    Inventors: Bernhard Fischer, Artur Mitterer, Friedrich Dorner, Hans-Peter Schwarz, Peter Turecek, Johann Eibl, Falko-Guenter Falkner, Uwe Schlokat, Wolfgang Mundt, Manfred Reiter, Renate Den-Bouwmeester