Patents by Inventor Renate Grassl

Renate Grassl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acids encoding bacteriophage tail proteins
    Patent number: 9229002
    Abstract: The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: January 5, 2016
    Assignee: Hyglos Invest GmbH
    Inventors: Stefan Miller, Roman Meyer, Renate Grassl, Manfred Biebl, Holger Grallert
  • Methods for purification of bacterial cells and cell components
    Patent number: 8932580
    Abstract: The present invention relates to a method for the selective purification of bacterial cells and/or cell components, whereby the purification is performed by means of a solid support.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: January 13, 2015
    Assignees: Hyglos Invest GmbH, Biomerieux S.A.
    Inventors: Michael Schutz, Renate Grassl, Roman Meyer, Sibylle Frick, Ingrid Robl, Thomas Zander, Stefan Miller
  • METHOD FOR DETECTING AND REMOVING ENDOTOXIN
    Publication number: 20140377775
    Abstract: The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
    Type: Application
    Filed: July 29, 2014
    Publication date: December 25, 2014
    Applicant: HYGLOS INVEST GMBH
    Inventors: Stefan MILLER, Roman MEYER, Renate GRASSL, Manfred BIEBL, Holger GRALLERT
  • Method for detecting and removing endotoxin
    Patent number: 8822641
    Abstract: The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: September 2, 2014
    Assignee: Hyglos Invest GmbH
    Inventors: Stefan Miller, Roman Meyer, Renate Grassl, Manfred Biebl, Holger Grallert
  • Bacteriophage adhesion proteins
    Patent number: 8609348
    Abstract: Bacteriophage adhesion proteins binding to the O-antigen of gram negative bacteria, but lacking the ability of binding to a bacteriophage and of hydrolysing lipopolysaccharides, are described, as well as nucleic acid molecules encoding the proteins. In addition, methods for generating the bacteriophage adhesion proteins and their use in detection, purification and enrichment of bacteria are described.
    Type: Grant
    Filed: July 3, 2009
    Date of Patent: December 17, 2013
    Assignee: Biomerieux S.A.
    Inventors: Manfred Biebl, Renate Grassl, Monika Walter, Stefan Miller
  • Endotoxin detection method
    Patent number: 8551719
    Abstract: The invention relates to a method for detecting endotoxins in a sample.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: October 8, 2013
    Assignee: Hyglos Invest GmbH
    Inventors: Roman Meyer, Michael Schütz, Holger Grallert, Renate Grassl, Stefan Miller
  • ENDOTOXIN DETECTION METHOD
    Publication number: 20130244224
    Abstract: The invention relates to a method for detecting endotoxins in a sample.
    Type: Application
    Filed: February 20, 2013
    Publication date: September 19, 2013
    Applicant: HYGLOS INVEST GMBH
    Inventors: Roman MEYER, Michael SCHÜTZ, Holger GRALLERT, Renate GRASSL, Stefan MILLER
  • Endotoxin detection method
    Patent number: 8394597
    Abstract: The invention relates to a method for detecting endotoxins in a sample.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: March 12, 2013
    Assignee: Hyglos Invest GmbH
    Inventors: Roman Meyer, Michael Schütz, Holger Grallert, Renate Grassl, Stefan Miller
  • Method for detecting and removing endotoxin
    Patent number: 8329393
    Abstract: The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
    Type: Grant
    Filed: July 12, 2011
    Date of Patent: December 11, 2012
    Assignee: Hyglos Invest GmbH
    Inventors: Stefan Miller, Roman Meyer, Renate Grassl, Manfred Biebl, Holger Grallert
  • NEW BACTERIOPHAGE ADHESION PROTEINS
    Publication number: 20120122124
    Abstract: The present invention relates to bacteriophage adhesion proteins binding to the O-antigen of gram negative bacteria, lacking the ability of binding to a bacteriophage and of hydrolysing lipopolysaccharides. The invention further relates to nucleic acid molecules comprising a sequence encoding the proteins according to the present invention. In addition, the present invention relates to a method for generating bacteriophage adhesion proteins according to the present invention. The invention further relates to the use of said proteins and methods of detection, purification and enrichment of bacteria.
    Type: Application
    Filed: July 3, 2009
    Publication date: May 17, 2012
    Inventors: Manfred Biebl, Renate Grassl, Monika Walter, Stefan Miller
  • Method For Detecting And Removing Endotoxin
    Publication number: 20110306068
    Abstract: The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
    Type: Application
    Filed: July 12, 2011
    Publication date: December 15, 2011
    Applicant: HYGLOS INVEST GMBH
    Inventors: Stefan Miller, Roman Meyer, Renate Grassl, Manfred Biebl, Holger Grallert
  • Method for detecting and removing endotoxin
    Patent number: 8003313
    Abstract: The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: August 23, 2011
    Assignee: Hyglos Invest GmbH
    Inventors: Stefan Miller, Roman Meyer, Renate Grassl, Manfred Biebl, Holger Grallert
  • ENDOTOXIN DETECTION METHOD
    Publication number: 20110053188
    Abstract: The invention relates to a method for detecting endotoxins in a sample.
    Type: Application
    Filed: December 20, 2004
    Publication date: March 3, 2011
    Applicant: HYGLOS INVEST GMBH
    Inventors: Roman Meyer, Michael Schütz, Holger Grallert, Renate Grassl, Stefan Miller
  • Method for unspecific enrichment of bacterial cells
    Patent number: 7868144
    Abstract: The present invention relates to a method for unspecific enrichment of bacterial cells by means of cationic or anionic polymers and magnetic carriers.
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: January 11, 2011
    Assignee: Hyglos Invest GmbH
    Inventors: Sabine Diller, Renate Grassl, Stefan Miller, Ingrid Robl, Michael Schütz, Thomas Zander
  • Methods for purification of bacterial cells and cell components
    Publication number: 20100047895
    Abstract: The present invention relates to a method for the selective purification of bacterial cells and/or cell components, whereby the purification is performed by means of a solid support.
    Type: Application
    Filed: July 28, 2009
    Publication date: February 25, 2010
    Applicants: Hyglos Invest GmbH, bioMerieux S.A.
    Inventors: Michael Schütz, Renate Grassl, Roman Meyer, Sibylle Frick, Ingrid Robl, Thomas Zander, Stefan Miller
  • Methods for purification of bacterial cells and components
    Patent number: 7579142
    Abstract: The present invention relates to a method for the selective purification of bacterial cells and/or cell components, whereby the purification is performed by means of a solid support.
    Type: Grant
    Filed: June 24, 2002
    Date of Patent: August 25, 2009
    Assignee: Profos AG
    Inventors: Michael Schütz, Renate Grassl, Roman Meyer, Sibylle Frick, Ingrid Robl, Thomas Zander, Stefan Miller
  • Method For Detecting And Removing Endotoxin
    Publication number: 20090017445
    Abstract: The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
    Type: Application
    Filed: January 23, 2006
    Publication date: January 15, 2009
    Applicant: PROFOS AG
    Inventors: Stefan Miller, Roman Meyer, Renate Grassl, Manfred Biebl, Holger Graller
  • Method for unspecific enrichment of bacterial cells
    Publication number: 20050019827
    Abstract: The present invention relates to a method for unspecific enrichment of bacterial cells by means of cationic or anionic polymers and magnetic carriers.
    Type: Application
    Filed: October 8, 2002
    Publication date: January 27, 2005
    Inventors: Sabine Diller, Renate Grassl, Stefan Miller, Ingrid Robl, Michael Schultz, Thomas Zander
  • Methods for purification of bacterial cells and components
    Publication number: 20040248298
    Abstract: The present invention relates to a method for the selective purification of bacterial cells and/or cell components, whereby the purification is performed by means of a solid support.
    Type: Application
    Filed: June 15, 2004
    Publication date: December 9, 2004
    Inventors: Michael Schutz, Renate Grassl, Roman Meyer, Sibylle Frick, Ingrid Robl, Thomas Zander, Stefan Miller