Patents by Inventor Renate Starr

Renate Starr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeted chimeric antigen receptor modified T cells for treatment of IL13RALPHA2 positive malignancies
    Patent number: 12551557
    Abstract: Chimeric antigen receptors targeted to IL-13Ra2 are described. The targeting domain is a IL13 variant having increased specificity for IL-13Ra2 relative to IL-13Ra1.
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: February 17, 2026
    Assignee: City of Hope
    Inventors: Christine E. Brown, Xin Yang, Renate Starr, Wen-Chung Chang, Stephen J. Forman
  • DETERMINISTIC MECHANOPORATION FOR CELL ENGINEERING
    Publication number: 20250263463
    Abstract: Intracellular delivery of a genetic construct to immune cells including: obtaining a deterministic mechanoporation (DMP) platform that includes a substrate having a surface and a plurality of capture sites, each said capture site having a boundary shape at the surface adapted and configured to support thereon a cell, and each said capture site having a bottom and including a sub-micron-scale projection extending from the bottom toward the surface of the substrate, wherein said projection is adapted and configured to penetrate a cell membrane and/or wall of the cell, and wherein the substrate has a plurality of aspiration vias situated at the bottom of the capture sites; introducing the cells to the surface in a liquid media; capturing the cells within the capture sites by applying a first hydrodynamic force; applying a second hydrodynamic force on the captured cell and locally rupturing the membrane and/or wall of the cell with the projection, introducing the genetic construct into the cells, and releasing th
    Type: Application
    Filed: April 25, 2025
    Publication date: August 21, 2025
    Inventors: Masaru P. Rao, Harish G. Dixit, Hideaki Tsutsui, Morgan L. Dundon, Pranee I. Pairs, Stephen J. Forman, Christine E. Brown, Renate Starr, Christopher B. Ballas
  • DETERMINISTIC MECHANOPORATION FOR CELL ENGINEERING
    Publication number: 20240058382
    Abstract: Intracellular delivery of a genetic construct to immune cells including: obtaining a deterministic mechanoporation (DMP) platform that includes a substrate having a surface and a plurality of capture sites, each said capture site having a boundary shape at the surface adapted and configured to support thereon a cell, and each said capture site having a bottom and including a sub-micron-scale projection extending from the bottom toward the surface of the substrate, wherein said projection is adapted and configured to penetrate a cell membrane and/or wall of the cell, and wherein the substrate has a plurality of aspiration vias situated at the bottom of the capture sites; introducing the cells to the surface in a liquid media; capturing the cells within the capture sites by applying a first hydrodynamic force; applying a second hydrodynamic force on the captured cell and locally rupturing the membrane and/or wall of the cell with the projection, introducing the genetic construct into the cells, and releasing th
    Type: Application
    Filed: October 30, 2023
    Publication date: February 22, 2024
    Inventors: Masaru P. Rao, Harish G. Dixit, Hideaki Tsutsui, Morgan L. Dundon, Pranee I. Pairs, Stephen J. Forman, Christine E. Brown, Renate Starr, Christopher B. Ballas
  • TARGETED CHIMERIC ANTIGEN RECEPTOR MODIFIED T CELLS FOR TREATMENT OF IL13RALPHA2 POSITIVE MALIGNANCIES
    Publication number: 20230405119
    Abstract: Chimeric antigen receptors targeted to IL-13Ra2 are described. The targeting domain is a IL13 variant having increased specificity for IL-13Ra2 relative to IL-13Ra1.
    Type: Application
    Filed: March 12, 2021
    Publication date: December 21, 2023
    Inventors: Christine E. Brown, Xin Yang, Renate Starr, Wen-Chung Chang, Stephen J. Forman
  • DETERMINISTIC MECHANOPORATION FOR CELL ENGINEERING
    Publication number: 20200289568
    Abstract: Intracellular delivery of a genetic construct to immune cells including: obtaining a deterministic mechanoporation (DMP) platform that includes a substrate having a surface and a plurality of capture sites, each said capture site having a boundary shape at the surface adapted and configured to support thereon a cell, and each said capture site having a bottom and including a sub-micron-scale projection extending from the bottom toward the surface of the substrate, wherein said projection is adapted and configured to penetrate a cell membrane and/or wall of the cell, and wherein the substrate has a plurality of aspiration vias situated at the bottom of the capture sites; introducing the cells to the surface in a liquid media; capturing the cells within the capture sites by applying a first hydrodynamic force; applying a second hydrodynamic force on the captured cell and locally rupturing the membrane and/or wall of the cell with the projection, introducing the genetic construct into the cells, and releasing th
    Type: Application
    Filed: March 10, 2020
    Publication date: September 17, 2020
    Inventors: Masaru P. Rao, Harish G. Dixit, Hideaki Tsutsui, Morgan L. Dundon, Pranee I. Pairs, Stephen J. Forman, Christine E. Brown, Renate Starr, Christopher B. Ballas