Abstract: An automated latching and release system is adapted for use with carts of the type configured for materials handling and a vehicle such as a semi-truck trailer used to transport such carts. A latching mechanism includes a latch member which physically engages with a cart so as to retain the cart in a transport position, and one or more switches physically remote from the latching mechanism, enabling an operator to release a cart without having to manipulate the latch member directly. The latching mechanism is preferably located within the forward section of the transport vehicle to make a coupling engagement with the forwardmost cart of a joined train of carts. With at least one of the switches positioned proximate to the rearward section of the transport vehicle, a user may disengage the set of carts from the latching mechanism and remove the set of carts through the rearward section of the vehicle without having to visit the forward section of the transport vehicle.