Patents by Inventor Renato Skerlj

Renato Skerlj has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CXCR4 inhibitors and uses thereof
    Patent number: 11780837
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: March 14, 2022
    Date of Patent: October 10, 2023
    Assignee: X4 Pharmaceuticals, Inc.
    Inventors: Elyse Marie Josee Bourque, Renato Skerlj
  • CXCR4 INHIBITORS AND USES THEREOF
    Publication number: 20220372032
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: March 14, 2022
    Publication date: November 24, 2022
    Inventors: Elyse Marie Josee BOURQUE, Renato SKERLJ
  • CXCR4 inhibitors and uses thereof
    Patent number: 11332470
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: May 17, 2022
    Assignee: X4 Pharmaceuticals, Inc.
    Inventors: Elyse Marie Josee Bourque, Renato Skerlj
  • CXCR4 inhibitors and uses thereof
    Patent number: 11306088
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: April 19, 2022
    Assignee: X4 Pharmaceuticals, Inc.
    Inventors: Elyse Marie Josee Bourque, Renato Skerlj
  • GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
    Publication number: 20220073508
    Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.
    Type: Application
    Filed: April 14, 2021
    Publication date: March 10, 2022
    Applicant: Genzyme Corporation
    Inventors: Elyse BOURQUE, Mario A. CABRERA-SALAZAR, Cassandra CELATKA, Seng H. CHENG, Bradford HIRTH, Andrew GOOD, Katherine JANCSICS, John MARSHALL, Markus METZ, Ronald K. SCHEULE, Renato SKERLJ, Yibin XIANG, Zhong ZHAO, John LEONARD, Thomas NATOLI, Elina MAKINO, Herve HUSSON, Oxana BESKROVNAYA
  • DEUTERATED COMPOUNDS AND USES THEREOF
    Publication number: 20220017487
    Abstract: The present invention provides deuterium-enriched CXCR4 inhibitors, pharmaceutical compositions, and methods of using such deuterium-enriched CXCR4 inhibitors and pharmaceutical compositions to treat, prevent, or ameliorate a disease, disorder, or condition such as cancer or WHIM syndrome.
    Type: Application
    Filed: July 15, 2021
    Publication date: January 20, 2022
    Inventors: Elyse Marie Josee Bourque, Renato Skerlj
  • CXCR4 INHIBITORS AND USES THEREOF
    Publication number: 20210363139
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: March 22, 2021
    Publication date: November 25, 2021
    Inventors: Elyse Marie Josee BOURQUE, Renato SKERLJ
  • GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
    Publication number: 20210261557
    Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
    Type: Application
    Filed: April 27, 2021
    Publication date: August 26, 2021
    Applicant: GENZYME CORPORATION
    Inventors: Elyse BOURQUE, Mario CABRERA-SALAZAR, Cassandra CELATKA, Seng CHENG, Mary A. CROMWELL, Andrew GOOD, Bradford HIRTH, Katherine JANCSICS, John P. LEONARD, Lingyun LI, James LILLIE, Hanlan LIU, Elina MAKINO, John MARSHALL, Paul MASON, Markus METZ, Fazeela MORSHED, Thomas O'SHEA, Ronald SCHEULE, Renato SKERLJ, Bing WANG, Yibin XIANG, Zhong ZHAO
  • Glucosylceramide synthase inhibitors
    Patent number: 11008316
    Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS), such as Compound of Formula I, shown below, as defined herein, useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: May 18, 2021
    Assignee: GENZYME CORPORATION
    Inventors: Elyse Bourque, Mario A. Cabrera-Salazar, Cassandra Celatka, Seng H. Cheng, Bradford Hirth, Andrew Good, Katherine Jancsics, John Marshall, Markus Metz, Ronald K. Scheule, Renato Skerlj, Yibin Xiang, Zhong Zhao, John Leonard, Thomas Natoli, Elina Makino, Herve Husson, Oxana Beskrovnaya
  • CXCR4 inhibitors and uses thereof
    Patent number: 10988465
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: April 27, 2021
    Assignee: X4 PHARMACEUTICALS, INC.
    Inventors: Elyse Marie Josee Bourque, Renato Skerlj
  • CXCR4 INHIBITORS AND USES THEREOF
    Publication number: 20210047320
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: July 27, 2020
    Publication date: February 18, 2021
    Inventors: Elyse Marie Josee Bourque, Renato Skerlj
  • ACYCLIC CXCR4 INHIBITORS AND USES THEREOF
    Publication number: 20210009557
    Abstract: The present invention relates to compounds and methods useful for modulation, e.g. inhibition, of C-X-C receptor type 4 (CXCR4). The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: December 18, 2018
    Publication date: January 14, 2021
    Inventors: Elyse Marie Josee Bourque, Renato Skerlj
  • CXCR4 inhibitors and uses thereof
    Patent number: 10759796
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: September 1, 2020
    Assignee: X4 PHARMACEUTICALS, INC.
    Inventors: Elyse Marie Josee Bourque, Renato Skerlj
  • CXCR4 INHIBITORS AND USES THEREOF
    Publication number: 20200255414
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: June 21, 2017
    Publication date: August 13, 2020
    Inventors: Elyse Marie Josee Bourque, Renato Skerlj
  • CXCR4 INHIBITORS AND USES THEREOF
    Publication number: 20200123150
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: June 21, 2017
    Publication date: April 23, 2020
    Inventors: Elyse Marie Josee Bourque, Renato Skerlj
  • GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
    Publication number: 20200048266
    Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
    Type: Application
    Filed: August 15, 2019
    Publication date: February 13, 2020
    Inventors: Elyse BOURQUE, Mario CABRERA-SALAZAR, Cassandra CELATKA, Seng CHENG, Mary A. CROMWELL, Andrew GOOD, Bradford HIRTH, Katherine JANCSICS, John P. LEONARD, Lingyun LI, James LILLIE, Hanlan LIU, Elina MAKINO, John MARSHALL, Paul MASON, Markus METZ, Fazeela MORSHED, Thomas O'SHEA, Ronald SCHEULE, Renato SKERLJ, Bing WANG, Yibin XIANG, Zhong ZHAO
  • CXCR4 INHIBITORS AND USES THEREOF
    Publication number: 20190322671
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: June 21, 2017
    Publication date: October 24, 2019
    Inventors: Elyse Marie Josee Bourque, Renato Skerlj
  • GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
    Publication number: 20180065957
    Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.
    Type: Application
    Filed: April 18, 2017
    Publication date: March 8, 2018
    Applicant: Genzyme Corporation
    Inventors: Elyse BOURQUE, Mario A. CABRERA-SALAZAR, Cassandra CELATKA, Seng H. CHENG, Bradford Hirth, Andrew GOOD, Katherine JANCSICS, John MARSHALL, Markus Metz, Ronald K. SCHEULE, Renato SKERLJ, Yibin XIANG, Zhong ZHAO, John LEONARD, Thomas NATOLI, Elina MAKINO, Herve HUSSON, Oxana BESKROVNAYA
  • GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
    Publication number: 20160207933
    Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
    Type: Application
    Filed: August 25, 2015
    Publication date: July 21, 2016
    Inventors: Elyse BOURQUE, Mario CABRERA-SALAZAR, Cassandra CELATKA, Seng CHENG, Mary A. CROMWELL, Andrew GOOD, Bradford HIRTH, Katherine JANCSICS, John P. LEONARD, Lingyun LI, James LILLIE, Hanlan LIU, Elina MAKINO, John MARSHALL, Paul MASON, Markus METZ, Fazeela MORSHED, Thomas O'SHEA, Ronald SCHEULE, Renato SKERLJ, Bing WANG, Yibin XIANG, Zhong ZHAO
  • GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
    Publication number: 20150210681
    Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.
    Type: Application
    Filed: September 10, 2013
    Publication date: July 30, 2015
    Applicant: GENZYME CORPORATION
    Inventors: Elyse Bourque, Mario A. Cabrera-Salazar, Cassandra Celatka, Seng H. Cheng, Bradford Hirth, Andrew Good, Katherine Jancsics, John Marshall, Markus Metz, Ronald K. Scheule, Renato Skerlj, Yibin Xiang, Zhong Zhao, John Leonard, Thomas Natoli, Elina Makino, Herve Husson, Oxana Beskrovnaya