Patents by Inventor Rene? Alexander Bolt

Rene? Alexander Bolt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for non-invasively determining the concentration of an analyte by compensating for the effect of tissue hydration
    Patent number: 6635491
    Abstract: A method for determining the concentration of an analyte in tissues. The method involves compensating for a change in the value of an optical property of the tissues, such as, for example, the scattering coefficient, resulting from a change in the hydration status of the tissues.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: October 21, 2003
    Assignee: Abbott Labortories
    Inventors: Omar S. Khalil, Johannes Sake Kanger, Rene′ Alexander Bolt, Frits Frans Maria de Mul
  • Non-invasive sensor capable of determining optical parameters in a sample having multiple layers
    Patent number: 6630673
    Abstract: Apparatus and method for non-invasively measuring at least one optical parameter of a sample, particularly a sample of tissue that comprises a plurality of layers. The at least one parameter can be used to determine the presence or concentration of an analyte of interest in the sample of tissue. The apparatus and method of the present invention (1) measure light that is substantially reflected, scattered, absorbed, or emitted from a shallower layer of the sample of tissue, (2) measure light that is substantially reflected, scattered, absorbed, or emitted from a deeper layer of the sample of tissue, (3) determine at least one optical parameter for each of these layers, and (4) account for the effect of the shallower layer on the at least one optical parameter of the deeper layer. Specifying the sampling depth allows determinations of the optical properties of a specific layer of the sample of the tissue, e.g., dermis, and decreases interference from other layers, e.g.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: October 7, 2003
    Assignee: Abbott Laboratories
    Inventors: Omar S. Khalil, Xiaomao Wu, Johannes Sake Kanger, Rene' Alexander Bolt, Shu-Jen Yeh, Charles F. Hanna, Frits Frans Maria de Mul
  • Non-invasive sensor capable of determining optical parameters in a sample having multiple layers
    Publication number: 20020084417
    Abstract: Apparatus and method for non-invasively measuring at least one optical parameter of a sample, particularly a sample of tissue that comprises a plurality of layers. The at least one parameter can be used to determine the presence or concentration of an analyte of interest in the sample of tissue. The apparatus and method of the present invention (1) measure light that is substantially reflected, scattered, absorbed, or emitted from a shallower layer of the sample of tissue, (2) measure light that is substantially reflected, scattered, absorbed, or emitted from a deeper layer of the sample of tissue, (3) determine at least one optical parameter for each of these layers, and (4) account for the effect of the shallower layer on the at least one optical parameter of the deeper layer. Specifying the sampling depth allows determinations of the optical properties of a specific layer of the sample of the tissue, e.g., dermis, and decreases interference from other layers, e.g.
    Type: Application
    Filed: December 21, 2001
    Publication date: July 4, 2002
    Inventors: Omar S. Khalil, Xiaomao Wu, Johannes Sake Kanger, Rene Alexander Bolt, Shu-Jen Yeh, Charles F. Hanna, Frits Frans Maria de Mul
  • Non-invasive sensor capable of determining optical parameters in a sample having multiple layers
    Patent number: 6353226
    Abstract: Apparatus and method for non-invasively measuring at least one optical parameter of a sample, particularly a sample of tissue that comprises a plurality of layers. The at least one parameter can be used to determine the presence or concentration of an analyte of interest in the sample of tissue. The apparatus and method of the present invention (1) measure light that is substantially reflected, scattered, absorbed, or emitted from a shallower layer of the sample of tissue, (2) measure light that is substantially reflected, scattered, absorbed, or emitted from a deeper layer of the sample of tissue, (3) determine at least one optical parameter for each of these layers, and (4) account for the effect of the shallower layer on the at least one optical parameter of the deeper layer. Specifying the sampling depth allows determinations of the optical properties of a specific layer of the sample of the tissue, e.g., dermis, and decreases interference from other layers, e. g.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: March 5, 2002
    Assignee: Abbott Laboratories
    Inventors: Omar S. Khalil, Xiaomao Wu, Johannes Sake Kanger, Rene′ Alexander Bolt, Shu-Jen Yeh, Charles F. Hanna, Frits Frans Maria de Mul